CMAJ Open. 2018 Jan-Mar; 6(1): E19–E25.Published online 2018 Jan 9. doi: 10.9778/cmajo.20160154PMCID: PMC5912944PMID: 29335277Adverse effects of caffeinated energy drinks among youth and young adults in Canada: a Web-based surveyDavid Hammond, PhD, Jessica L. Reid, MSc, and Sara Zukowski, BScAuthor information Copyright and License information DisclaimerAffiliations: School of Public Health and Health Systems (Hammond, Reid, Zukowski), University of Waterloo, Waterloo, Ont.; School of Nursing (Zukowski),...
11:33
Microscopic Thyroidectomy: The Way We Do It: AbstractThe present study was conducted with an intent to document the reduced morbidity in terms of postoperative hypocalcemia, injury to recurrent laryngeal and external branch of superior laryngeal nerve, in patients undergoing microscope assisted thyroidectomy. The present study enrolled a total of 878 patrients who underwent hemi, total and completion thyroidectomies, over a period of 3 years at Jain ENT Hospital, Jaipur. In the present study, out...
11:25
Effectiveness of 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve, Compensated Cirrhotic Patients with Chronic Hepatitis C Infection: AbstractIntroductionGlecaprevir/pibrentasvir (G/P) was approved on 26 September 2019 by the US Food and Drug Administration for 8-week duration in treatment-naïve (TN) hepatitis C virus (HCV)-infected patients with compensated cirrhosis (CC). Evidence from the EXPEDITION-8 study demonstrated that 8 weeks of G/P achieved a 98% intent-to-treat (ITT) sustained virologic...
11:25
CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein: Publication date: Available online 11 April 2020Source: Experimental Cell ResearchAuthor(s): Fangqi Ma, Hong Wang, Kefen Liu, Zhongqiang Wang, Shijun Chen
11:25
Targeting the PI3K pathway and DNA damage response as a therapeutic strategy in ovarian cancer: Publication date: Available online 10 April 2020Source: Cancer Treatment ReviewsAuthor(s): Tzu-Ting Huang, Erika J. Lampert, Cynthia Coots, Jung-Min Lee
11:25
Impaired objective and subjective sleep in children and adolescents with inflammatory bowel disease compared to healthy controls: Poor sleep and higher inflammation markers are associated, and impaired sleep quality is common among patients with inflammatory bowel disease (IBD). However, information on sleep among children and adolescents with IBD is currently lacking. The aims of the present study were to compare subjective and objective sleep of children and adolescents with IBD with healthy controls...
11:24
Cancers, Vol. 12, Pages 949: The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications: Cancers, Vol. 12, Pages 949: The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic ImplicationsCancers doi: 10.3390/cancers12040949Authors: Marta Recagni Joanna Bidzinska Nadia Zaffaroni Marco Folini Telomere maintenance mechanisms (i.e., telomerase activity (TA) and the alternative lengthening of...
11:24
Cancers, Vol. 12, Pages 947: Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer Patients: Cancers, Vol. 12, Pages 947: Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer PatientsCancers doi: 10.3390/cancers12040947Authors: Anne Tranberg Madsen Anne Winther-Larsen Tine McCulloch Peter Meldgaard Boe Sandahl Sorensen...
11:23
Cancers, Vol. 12, Pages 948: Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility: Cancers, Vol. 12, Pages 948: Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 PermissibilityCancers doi: 10.3390/cancers12040948Authors: Henry E. Miller Aparna Gorthi Nicklas Bassani Liesl A. Lawrence Brian S. Iskra Alexander J. R. Bishop...
11:23
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14: Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by slowly progressive cerebellar dysfunction. Currently, 42 SCA types are known, some of which are caused by CAG repeat expansions, but others are caused by point mutations or deletions. Spinocerebellar ataxia type 14 (SCA14) is caused by missense mutations or deletions in the PRKCG gene, coding for protein...
11:23
The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties: Publication date: Available online 10 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Christine Hoesl, Enrica Zanuttigh, Thomas Fröhlich, Julia Philippou-Massier, Stefan Krebs, Helmut Blum, Maik Dahlhoff
11:22
Cancers, Vol. 12, Pages 952: Natural Killer Cells: Tumor Surveillance and Signaling: Cancers, Vol. 12, Pages 952: Natural Killer Cells: Tumor Surveillance and SignalingCancers doi: 10.3390/cancers12040952Authors: Meza Guzman Keating Nicholson Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic cells. The decision to kill is determined by the expression of a myriad of activating and inhibitory receptors on the...
11:22
Cancers, Vol. 12, Pages 946: TERT Promoter Mutations Differently Correlate with the Clinical Outcome of MAPK Inhibitor-Treated Melanoma Patients: Cancers, Vol. 12, Pages 946: TERT Promoter Mutations Differently Correlate with the Clinical Outcome of MAPK Inhibitor-Treated Melanoma PatientsCancers doi: 10.3390/cancers12040946Authors: Paola Del Bianco Camilla Stagni Silvia Giunco Alessio Fabozzi Lisa Elefanti Stefania Pellegrini Antonella Vecchiato Jacopo Pigozzo Carolina...
11:21
Spontaneous neck hematoma secondary to parathyroid adenoma: a case series: AbstractPurposeSpontaneous neck hematoma is a rare yet potentially fatal complication of primary hyperparathyroidism (PHPT). Here we aim to describe novel presentations of neck hematomas secondary to PHPT, discussing tools and signs that facilitate diagnosis.MethodsCase series data were extracted by retrospective chart reviews of our institution's electronic medical records, including all neck hematoma cases from parathyroid...
11:21
Association between TSHR gene methylation and papillary thyroid cancer: a meta-analysis: AbstractPurposeTo explore the association between the thyroid stimulating hormone receptor (TSHR) gene methylation and human papillary thyroid cancer (PTC), as well as PTC related clinicopathological indicators.MethodsWe searched PubMed, Embase, Medline, and Web of Science databases through computer for articles published in English on association between methylation of TSHR gene and PTC. Articles published in...
11:21
Respiratory properties of fresh black carrot ( Dacus Carota L.) based upon non-linear enzyme kinetics approach: AbstractThe present work was undertaken with an objective to evaluate the impact of temperature on respiration rate of fresh black carrot using a non-linear enzyme kinetics approach. Two different models viz. Arrhenius equation (temperature effect) and enzyme kinetics (effect of temperature and headspace concentration) have been compared for predicting the respiration rate of black carrot....
11:20
Current perspective on eicosanoids in asthma and allergic diseases ‐ EAACI Task Force consensus report, part I: AbstractEicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, thromboxanes and lipoxins, involved in several pathophysiological processes relevant to asthma, allergies and allied diseases. Prostaglandins and leukotrienes are the most studied eicosanoids and established inducers of airway pathophysiology including bronchoconstriction and airway inflammation....
11:19
GENDER AND OCCUPATIONAL ALLERGY (GOA): Report from the task force of the EAACI Environmental & Occupational Allergy Interest Group: AbstractWomen's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregation), with women also under‐represented...
11:19
Distinct characteristics of COVID‐19 patients with initial rRT‐PCR positive and negative results for SARS‐CoV‐2: AbstractSince the coronavirus disease 2019 (COVID‐19) caused by SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2) first emerged in Wuhan, China in December 2019, the outbreak of COVID‐19 epidemic has become an increasingly serious global health concern. Currently, over 150 countries have reported COVID‐19 cases, and the situation has progressed to a pandemic associated with...
11:19
Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer: AbstractThe brain is often reported as the first site of recurrence among breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2). Although most HER2+tumors metastasize to the subcortical region of the brain, a subset develops in the cortical region. We hypothesize that factors in cerebrospinal fluid (CSF) play a critical role in the adaptation, proliferation, and establishment...
11:18
A comparison of endoscopic transtympanic myringoplasty and endoscopic type I tympanoplasty for repairing medium- to large-sized tympanic membrane perforation: a randomized clinical trial: AbstractIntroductionEndoscopic type I tympanoplasty (ETT) is currently accepted as an effective, minimally traumatic procedure for repairing tympanic membrane perforation. However, ETT requires tympanomeatal flap elevation which chorda tympani nerve injury, bleeding and wound healing are the drawbacks of this technique....
11:18
Identification of Rare and Common HPV Genotypes in Sinonasal Papillomas: AbstractSinonasal papillomas are rare, usually benign tumors arising from the Schneiderian membrane. Human papillomaviruses (HPV) can infect differentiating skin and mucosal cells and can induce uncontrolled growth patterns. Their effect on development of sinonasal papillomas has been discussed controversially in recent years. A monocentric, retrospective study was conducted to investigate histopathologic features of sinonasal...
11:18
The removal of lead, copper, zinc and cadmium from aqueous solution by biochar and amended biochars: AbstractThe exponential growth in the use of motor vehicles is a key contributor to freshwater degradation. Current remediation techniques require prohibitively expensive contaminant treatment and extraction. Biochar represents an inexpensive option to ameliorate contaminants from motorway runoff. Biochar from Norway spruce (Picea abies (L.) Karst.) was produced under fast pyrolysis-gasification (450–500 °C...
11:17
Early life acetaminophen exposure, Glutathione S-Transferase genes and development of adolescent asthma in a high-risk birth cohort: Our findings strengthen the evidence implicating acetaminophen as a possible cause for asthma and reduced lung function, particularly in those with susceptible genetic polymorphisms. Further research is needed before altering guidelines on acetaminophen use.
11:16
Introducing Human Adipose-Derived Mesenchymal Stem Cells to Avance® Nerve Grafts and NeuraGen® Nerve Guides: When direct nerve coaptation is impossible after peripheral nerve injury, autografts, processed allografts, or conduits are used to bridge the nerve gap. The purpose of this study was to examine if human adipose-derived Mesenchymal Stromal/Stem Cells (MSCs) could be introduced to commercially available nerve graft substitutes and to determine cell distribution and the seeding efficiency of...
11:16
Molecular Aspects of Regional Pain Syndrome: The purpose of this review is to summarize the pathophysiology of complex regional pain syndrome (CRPS), the underlying molecular mechanisms, and potential treatment options for its management. CRPS is a multifactorial pain condition. CRPS is characterized by prolonged or excessive pain and changes in skin color and temperature, and/or swelling in the affected area, and is generally caused by stimuli that lead to tissue damage. An inflammatory response...
11:16
Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties: Background. Myocarditis is one of the important causes of dilated cardiomyopathy, cardiac morbidity, and mortality worldwide. Chitosan oligosaccharides (COS) may have anti-inflammatory and cardioprotective effects on myocarditis. However, the exact molecular mechanism for the effects of functional COS on myocarditis remains unclear. Methods. Anti-inflammatory...
11:15
High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi: Treatment for Chagas disease, a parasitosis caused by Trypanosoma cruzi, has always been based on two drugs, nifurtimox and benznidazole, despite the toxic side effects described after prolonged prescription. In this work, we study a new prospective antitrypanosomal drug based on vanadium, here named VIVO(5Brsal)(aminophen). We found a good IC50 value, (3.76 ± 0.08) μM, on CL...
11:15
MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling: Background. Gut barrier dysfunction with alterant mucosal permeability during sepsis is a challenge problem in clinical practice. Intestinal epithelial cells (IECs) are strongly involved in mucosal oxidative stress and inflammatory response. The current study aimed at investigating the effect of MitoQ, a mitochondrial targeted antioxidant, in the treatment of intestinal injury and its potential...
11:14
Association between long-term exposure to Sulfur dioxide pollution and hypertension incidence in northern China: a 12-year cohort study: AbstractSeveral studies have researched the short-term effect of sulfur dioxide (SO2) exposure on hypertension. However, no evidence has provided the relationship between long-term high pollution exposure of SO2 and morbidity of hypertension in cohort studies in China. This retrospective cohort study aimed to evaluate this association. We used Cox proportional hazards...
11:13
Effect of the extracellular component of bone marrow mesenchymal stromal cells from healthy donors on hematologic neoplasms and their angiogenesis: AbstractBone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors are a promising source of cell therapy. However, their effectiveness in cancer remains less known. This study is the first to evaluate the quality of BM-MSCs obtained from young and elderly healthy volunteers (KNT cells). The KNT cells had normal karyotypes and were positive for...
11:13
Acute lymphoblastic leukemia clonal distribution between bone marrow and peripheral blood: AbstractAcute lymphoblastic leukemia (ALL) is often composed of numerous subclones. Here we test whether the clonal composition of the blood is representative of the bone marrow at leukemia onset. Using ultra‐deep IGH sequencing, we detected 28 clones across 16 patients; 5/28 were only in the marrow. In four patients, the most abundant clones differed between sites, including three in which the dominant medullary...
11:13
Multicystic and diffuse malignant peritoneal mesothelioma in children: AbstractBackgroundMalignant and multicystic peritoneal mesotheliomas are extremely rare tumors in children, developing from mesothelial cells. No specific guidelines are available at this age.MethodsWe performed a retrospective analysis of all identified children (< 18‐year‐old) treated in France from 1987 to 2017 for a diffuse malignant peritoneal mesothelioma (DMPM) or a multicystic peritoneal mesothelioma (MCPM).ResultsFourteen...
11:12
Congenital neutropenia with variable clinical presentation in novel mutation of the SRP54 gene: AbstractBackgroundThe SRP54 (signal recognition protein 54) is a conserved component of the ribonucleoprotein complex that mediates cotranslational targeting and translocation of proteins to the endoplasmic reticulum. In 2017, mutations in the gene have been described as a cause of congenital neutropenia with or without pancreatic insufficiency, and since then, only limited cases were added to the literature.MethodsTwo...
11:12
The use of google trends to investigate the loss of smell related searches during COVID‐19 outbreak: BackgroundInitial reports describing COVID‐19 were dominated by the presence of cough, breathlessness, and fever, anecdotal reports suggested anosmia may also be a manifestation. We sought to use Google Trends (GT) to investigate whether there was a surge in individuals searching for information related to smell loss during the COVID‐19 epidemic in the Italy, Spain, UK, USA, Germany, France, Iran...
11:12
ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription: AbstractAbsent, small or homeotic 2‐like protein (ASH2L) is a core component of multimeric histone methyltransferase complex, which is involved in maintenance of active transcription, participating in several cancers. However, the biological function and molecular mechanism of ASH2L in endometrial cancer (ECa) is largely unknown. Endometrial cancer is one of the common female malignant tumors...
11:11
ACTR confers to Sorafenib resistance in hepatocellular carcinoma via facilitating the Warburg effect
ACTR confers to Sorafenib resistance in hepatocellular carcinoma via facilitating the Warburg effect: AbstractSorafenib resistance is a major challenge in the therapy for advanced hepatocellular carcinoma (HCC)1. However, the underlying molecular mechanism of HCC resistance to sorafenib remains unclear. Activator of thyroid and retinoid receptor (ACTR, also known as SRC‐3), overexpressed in HCC patients, plays an important oncogenic role in HCC, however, the link between ACTR and sorafenib resistance...
11:11
Five‐year safety and efficacy data from a phase Ib study of nivolumab and chemotherapy in advanced non–small‐cell lung cancer: AbstractCombination anti‐programmed death 1/programmed death‐ligand 1 antibody and platinum‐based chemotherapy is standard first‐line treatment for advanced non–small‐cell lung cancer without targetable oncogene alterations. We describe the long‐term safety and efficacy data from a previously reported phase Ib study of nivolumab and chemotherapy. Japanese patients with non–small‐cell...
11:11
CD20+ tumor‐infiltrating immune cells and CD204+ M2 macrophages are associated with prognosis in thymic carcinoma: AbstractThymic carcinoma is a rare malignant disease with no standard systemic chemotherapy. The purpose of the present study was to investigate tumor‐infiltrating immune cells (TIICs) in the tumor microenvironment (TME), mainly the impact of TIICs and PD‐L1 expression on clinical outcomes in thymic cancer.Patients with thymic carcinoma resected between 1973 and 2017 were investigated....
11:10
Acceleration of BRAF V600E -induced thyroid carcinogenesis by TGFβ signal deficiency in mice: AbstractPurposeTransforming growth factor-β (TGFβ) has pleiotropic actions, including both anti- and pro-tumorigenic abilities. We have previously shown no tumor development in the thyroid-specific TGFβ receptor type II knockout (Tgfβr2 KO) mice, indicating the insufficiency of defective TGFβ signal itself for thyroid cancer initiation. In the current study, we evaluated whether defective TGFβ signal accelerates...
11:10
A novel whole blood gene expression signature for asthma, dermatitis and rhinitis multimorbidity in children and adolescents: AbstractBackgroundAllergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large‐scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes.MethodsIntegrated transcriptomic analysis was conducted in 1,233 participants with...
11:09
Impact of manual thrombectomy on microvascular obstruction in STEMI patients: AbstractObjectiveTo assess the effect of manual thrombectomy (MT) on microvascular obstruction (MVO) using cardiac magnetic resonance (CMR) in ST‐segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI).Methods and resultsThree hundred and eighty‐three patients admitted for STEMI and undergoing CMR fulfilled the inclusion criteria and were categorized into two...
11:09
Incidence, risk, and treatment of binary restenosis after vertebral artery stenting: AbstractBackgroundIn‐stent restenosis (ISR) is the major concern of vertebral artery stenting (VAS). We aimed to investigate the feasibility and outcome of redo angioplasty for ISR of vertebral artery.MethodThe patients were retrospectively reviewed for the significant ISR (>50%). Redo angioplasty including balloon angioplasty and stenting was performed for symptomatic ISR (>50%) or asymptomatic ISR (≥70%)....
11:09
High expression of Krüppel‐like factor 5 is associated with poor prognosis in patients with colorectal cancer: AbstractKrüppel‐like factor 5 plays an oncogenic role and has diverse functions in cancer cells. However, correlation between Krüppel‐like factor 5 and clinical outcome has not been demonstrated in patients with colorectal cancer and colorectal liver metastasis. Herein, we analyzed 65 patients with colorectal cancer who developed colorectal liver metastasis. Clinical effects were assessed...
11:08
Episodic memory consolidation during sleep in healthy aging.: Related ArticlesEpisodic memory consolidation during sleep in healthy aging.Sleep Med Rev. 2020 Mar 16;52:101304Authors: Muehlroth BE, Rasch B, Werkle-Bergner MAbstract Sleep benefits the stabilization of newly acquired information - a process known as memory consolidation. Age-related alterations in sleep physiology may affect memory consolidation and account for reduced episodic memory performance in healthy older individuals....
11:08
Cancers, Vol. 12, Pages 951: EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways: Cancers, Vol. 12, Pages 951: EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling PathwaysCancers doi: 10.3390/cancers12040951Authors: ...
11:07
Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.: Related ArticlesKaryopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.Cancers (Basel). 2020 Apr 08;12(4):Authors: Hazawa M, Yoshino H, Nakagawa Y, Shimizume R, Nitta K, Sato Y, Sato M, Wong RW, Kashiwakura IAbstract Nuclear transport...
11:07
Contribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries.: Related ArticlesContribution of the Potassium Channels KV1.3 and KCa3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries.Cells. 2020 Apr 08;9(4):Authors: Lasch M, Caballero Martinez A, Kumaraswami K, Ishikawa-Ankerhold H, Meister S, Deindl EAbstract Collateral artery growth (arteriogenesis) involves the proliferation of vascular endothelial cells (ECs)...
11:06
Investigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends.
Investigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends.: Related ArticlesInvestigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends.Allergol Int. 2020 Apr 07;:Authors: Iinuma T, Yonekura S, Sakurai D, Inaba Y, Kawasaki Y, Okamoto YPMID: 32276817 [PubMed - as supplied by publisher]
11:06
Atlas based segmentation in prone breast cancer radiation therapy.: Related ArticlesAtlas based segmentation in prone breast cancer radiation therapy.Med Dosim. 2020 Apr 08;:Authors: Stross WC, Herchko SM, Vallow LAAbstract The evidence supporting atlas based contour generation is growing and includes breast, prostate, central nervous system, gastrointestinal, gynecologic, and head and neck cancer patient populations. We sought to investigate atlas based segmentation (ABS) in patients with...
11:06
A genome-wide association study identifies two novel susceptible regions for squamous cell carcinoma of the head and neck.: Related ArticlesA genome-wide association study identifies two novel susceptible regions for squamous cell carcinoma of the head and neck.Cancer Res. 2020 Apr 10;:Authors: Shete S, Liu H, Wang J, Yu R, Sturgis EM, Li G, Dahlstrom KR, Liu Z, Amos CI, Wei QAbstract To identify genetic variants for risk of squamous cell carcinoma of the head and neck (SCCHN), we conducted...
11:06
Effect of tumor burden and growth rate on treatment outcomes of nivolumab in head and neck cancer.: Related ArticlesEffect of tumor burden and growth rate on treatment outcomes of nivolumab in head and neck cancer.Int J Clin Oncol. 2020 Apr 10;:Authors: Suzuki C, Kiyota N, Imamura Y, Rikitake J, Sai S, Koyama T, Hyogo Y, Nagatani Y, Funakoshi Y, Toyoda M, Otsuki N, Nibu KI, Minami HAbstract BACKGROUND: Nivolumab improves overall survival (OS) in patients with platinum-refractory recurrent...
11:05
Effectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea.
Effectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea.: Related ArticlesEffectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea.Sleep Breath. 2020 Apr 10;:Authors: Smith DF, He S, Peddireddy NS, Vairavan Manickam P, Heubi CH, Shott SR, Cohen AP, Ishman SLAbstract STUDY OBJECTIVES: Because dexmedetomidine (DEX)-induced sedation mimics non-rapid eye movement (NREM) sleep, its utility in sedating children...
11:05
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis.: Related ArticlesPrognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis.Oral Dis. 2020 Apr 11;:Authors: Kisoda S, Shao W, Fujiwara N, Mouri Y, Tsunematsu T, Jin S, Arakaki R, Ishimaru N, Kudo YAbstract OBJECTIVE: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial...
11:05
Long noncoding RNA MEG3 decreases the growth of head and neck squamous cell carcinoma by regulating the expression of miR-421 and E-cadherin.: Related ArticlesLong noncoding RNA MEG3 decreases the growth of head and neck squamous cell carcinoma by regulating the expression of miR-421 and E-cadherin.Cancer Med. 2020 Apr 11;:Authors: Ji Y, Feng G, Hou Y, Yu Y, Wang R, Yuan HAbstract BACKGROUND: Maternally expressed 3 (MEG3), a long chain noncoding RNA (lncRNA), has verified its function as...
11:04
MicroRNA-205 targets HER3 and suppresses the growth, chemosensitivity and metastasis of human nasopharyngeal carcinoma cells.: Related ArticlesMicroRNA-205 targets HER3 and suppresses the growth, chemosensitivity and metastasis of human nasopharyngeal carcinoma cells.J BUON. 2020 Jan-Feb;25(1):350-356Authors: Hao Y, Li J, Zhang H, Guan G, Guo YAbstract PURPOSE: Nasopharyngeal carcinoma is one of the lethal cancers prevalent in Southeast Asia and Southern China. The frequent relapses, development...
11:04
Novel insights into laryngeal squamous cell carcinoma from association study of aberrantly expressed miRNAs, lncRNAs and clinical features in Bulgarian patients.: Related ArticlesNovel insights into laryngeal squamous cell carcinoma from association study of aberrantly expressed miRNAs, lncRNAs and clinical features in Bulgarian patients.J BUON. 2020 Jan-Feb;25(1):357-366Authors: Garo Kyurkchiyan S, Miroslavov Popov T, Stancheva G, Rangachev J, Ivanov Mitev V, Petrova Popova D, Petrova Kaneva RAbstract...
11:04
Zero-Degree Endoscopic Visualization of the Frontal Sinus Predicts Improved Topical Irrigation Delivery.: Related ArticlesZero-Degree Endoscopic Visualization of the Frontal Sinus Predicts Improved Topical Irrigation Delivery.Laryngoscope. 2020 Apr 11;:Authors: Spielman DB, Kim M, Overdevest J, Gudis DAAbstract OBJECTIVE: Management of chronic frontal rhinosinusitis is challenging with high rates of treatment failure, exacerbated by limitations of topical irrigation delivery. We hypothesize...
11:04
Tracheotomy Timing and Outcomes in the Critically Ill: Complexity and Opportunities for Progress.: Related ArticlesTracheotomy Timing and Outcomes in the Critically Ill: Complexity and Opportunities for Progress.Laryngoscope. 2020 Apr 11;:Authors: Altman KW, Ha TN, Dorai VK, Mankidy BJ, Zhu HAbstract OBJECTIVES/HYPOTHESIS: To characterize the effects of tracheotomy timing at our institution on intensive care unit (ICU) length of stay (LOS) and overall hospital LOS. STUDY DESIGN: Retrospective...
11:03
Longer upper airway lengths in Robin Sequence: a case control study using computed tomography.: Related ArticlesLonger upper airway lengths in Robin Sequence: a case control study using computed tomography.Paediatr Anaesth. 2020 Apr 11;:Authors: Perez FA, Hottinger DG, Evans KN, Giles M, Otto RK, Hunyady A, Gentry KRAbstract BACKGROUND: Direct laryngoscopy and intubation are often difficult in children with Robin Sequence. Previous research characterizing anatomic airway differences has focused...
11:03
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.: Related ArticlesTransfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.Immunity. 2020 Apr 07;:Authors: Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang...
11:03
Liposomal Bupivacaine in Rhinoplasty: An Underused Tool.: Related ArticlesLiposomal Bupivacaine in Rhinoplasty: An Underused Tool.J Oral Maxillofac Surg. 2020 Mar 13;:Authors: Barinsky GL, Bresler AY, Paskhover BPMID: 32277938 [PubMed - as supplied by publisher]
11:03
Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis.: Related ArticlesApelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis.Neurosci Lett. 2020 Apr 08;:134948Authors: Yin H, Zhang H, Kong Y, Wang C, Guo Y, Gao Y, Yuan L, Yang X, Chen JAbstract Apelin, a specific endogenous ligand of the G protein-coupled receptor APJ, suppresses oxidative stress and apoptosis in vitro and in vivo. The current...
11:02
Human oocytes harboring damaged DNA can complete meiosis I.: Related ArticlesHuman oocytes harboring damaged DNA can complete meiosis I.Fertil Steril. 2020 Apr 07;:Authors: Rémillard-Labrosse G, Dean NL, Allais A, Mihajlović AI, Jin SG, Son WY, Chung JT, Pansera M, Henderson S, Mahfoudh A, Steiner N, Agapitou K, Marangos P, Buckett W, Ligeti-Ruiter J, FitzHarris GAbstract OBJECTIVE: To determine whether human oocytes possess a checkpoint to prevent completion of meiosis I when DNA is damaged....
11:01
Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis.: Related ArticlesResistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis.Braz J Phys Ther. 2020 Mar 12;:Authors: Vasilceac FA, Marqueti RC, Neto IVS, Nascimento DDC, Souza MC, Durigan JLQ, Mattiello SMAbstract BACKGROUND: Osteoarthritis (OA) is a degenerative disease that induces peri-articular tissue degradation....
11:00
Transdiagnostic and Illness-Specific Functional Dysconnectivity Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.: Related ArticlesTransdiagnostic and Illness-Specific Functional Dysconnectivity Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Feb 10;:Authors: Huang CC, Luo Q, Palaniyappan L, Yang AC, Hung CC, Chou KH, Zac Lo CY, Liu MN, Tsai SJ, Barch DM, Feng J, Lin CP, Robbins TWAbstract BACKGROUND:...
11:00
Maxillofacial Injuries as an Occupational Hazard of Farming in Rural and Semi-urban Population: A 3-Year Retrospective Epidemiological Study: AbstractPurposeThe aim of the retrospective study is to conduct an epidemiological evaluation of farm-based/farm-related maxillofacial injuries to assess the pattern and severity of maxillofacial injuries sustained and to formulate prevention strategies.Materials & MethodIn this analytical retrospective study, records/case sheets of patients presenting...
11:00
Frequent and mild scrotal heat stress impairs embryo development, implantation and offspring sex ratio in mice.: Related ArticlesFrequent and mild scrotal heat stress impairs embryo development, implantation and offspring sex ratio in mice.Reprod Biomed Online. 2020 Feb 01;:Authors: Wan X, He X, Liu Q, Duan P, Li HAbstract RESEARCH QUESTION: Frequent and mild scrotal heat stress (fmSHS) often occurs in humans. The aim of this study was to determine the impact of fmSHS on natural fertility,...
10:59
Preparation of Uracil by bacteria isolated from Morchella.: Related ArticlesPreparation of Uracil by bacteria isolated from Morchella.Pak J Pharm Sci. 2020 Mar;33(2):621-625Authors: Fu S, Zhang Y, Yang C, Meng QAbstract Morchella is one of the most famous rare edible and medicinal fungi over the world. Highly nutritious and immature cultivation techniques led to the high price and the markets have remained tight. The pathogenic bacteria were serious in artificial cultivation of Morchella...
10:59
Molecular docking, synthesis and biological evaluation of phenacyl derivatives of 9-aminoacridine as anti-Alzheimer's agent.: Related ArticlesMolecular docking, synthesis and biological evaluation of phenacyl derivatives of 9-aminoacridine as anti-Alzheimer's agent.Pak J Pharm Sci. 2020 Mar;33(2):659-668Authors: Munawar R, Mushtaq N, Ahmad A, Saeed SMG, Usmani S, Akhtar S, Saify ZS, Arif M, Akram AAbstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder mainly characterized...
10:59
3D printable device for automated operant conditioning in the mouse.: Related Articles3D printable device for automated operant conditioning in the mouse.eNeuro. 2020 Apr 07;:Authors: Mazziotti R, Sagona G, Lupori L, Martini V, Pizzorusso TAbstract Operant conditioning is a classical paradigm and a standard technique used in experimental psychology in which animals learn to perform an action in order to achieve a reward. By using this paradigm, it is possible to extract learning curves and...
10:59
M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.: Related ArticlesM2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.Sci Immunol. 2020 Apr 10;5(46):Authors: Lee SH, Chaves MM, Kamenyeva O, Gazzinelli-Guimaraes PH, Kang B, Pessenda G, Passelli K, Tacchini-Cottier F, Kabat J, Jacobsen EA, Nutman TB, Sacks DLAbstract Tissue-resident...
10:58
Food workers as a reservoir of extended-spectrum cephalosporin-resistant Salmonella in Japan.: Related ArticlesFood workers as a reservoir of extended-spectrum cephalosporin-resistant Salmonella in Japan.Appl Environ Microbiol. 2020 Apr 10;:Authors: Shigemura H, Sakatsume E, Sekizuka T, Yokoyama H, Hamada K, Etoh Y, Carle Y, Mizumoto S, Hirai S, Matsui M, Kimura H, Suzuki M, Onozuka D, Kuroda M, Inoshima Y, Murakami KAbstract Dissemination of extend-spectrum cephalosporin (ESC)-resistant...
10:58
The Cognitive Effects of Statins are Modified by Age.: Related ArticlesThe Cognitive Effects of Statins are Modified by Age.Sci Rep. 2020 Apr 10;10(1):6187Authors: Alsehli AM, Olivo G, Clemensson LE, Williams MJ, Schiöth HBAbstract To reveal new insights into statin cognitive effects, we performed an observational study on a population-based sample of 245,731 control and 55,114 statin-taking individuals from the UK Biobank. Cognitive performance in terms of reaction time, working memory and...
10:58
Association between preoperative tumor necrosis factor alpha inhibitor and surgical site infection after surgery for inflammatory bowel disease: a systematic review and meta-analysis.: Related ArticlesAssociation between preoperative tumor necrosis factor alpha inhibitor and surgical site infection after surgery for inflammatory bowel disease: a systematic review and meta-analysis.Surg Today. 2020 Apr 10;:Authors: Uchino M, Ikeuchi H, Shimizu J, Ohge H, Haji S, Mizuguchi T, Mohri Y, Yamashita C,...
10:57
Comparative bioinformatical analysis of pancreatic head cancer and pancreatic body/tail cancer.: Related ArticlesComparative bioinformatical analysis of pancreatic head cancer and pancreatic body/tail cancer.Med Oncol. 2020 Apr 10;37(5):46Authors: Yin L, Xiao L, Gao Y, Wang G, Gao H, Peng Y, Zhu X, Wei J, Miao Y, Jiang K, Lu ZAbstract This study is to analyze differentially expressed genes (DEGs) and mutation signatures of pancreatic head cancer and pancreatic body/tail cancer. Pancreatic...
10:57
Proportion and risk factors of cholesterol crystal embolization after cardiovascular procedures: a retrospective national database study.: Related ArticlesProportion and risk factors of cholesterol crystal embolization after cardiovascular procedures: a retrospective national database study.Heart Vessels. 2020 Apr 10;:Authors: Tanaka H, Yamana H, Matsui H, Fushimi K, Yasunaga HAbstract Cholesterol crystal embolization (CCE) is a rare, mainly iatrogenic condition. The proportion of CCE after...
10:57
Perioperative and oncologic outcome of robot-assisted minimally invasive (hybrid laparoscopic and robotic) pancreatoduodenectomy: based on pancreatic fistula risk score and cancer/staging matched comparison with open pancreatoduodenectomy.: Related ArticlesPerioperative and oncologic outcome of robot-assisted minimally invasive (hybrid laparoscopic and robotic) pancreatoduodenectomy: based on pancreatic fistula risk score and cancer/staging matched comparison with open pancreatoduodenectomy.Surg...
10:57
Arsenate removal from drinking water using by-products from conventional iron oxyhydroxides production as adsorbents coupled with submerged microfiltration unit.: Related ArticlesArsenate removal from drinking water using by-products from conventional iron oxyhydroxides production as adsorbents coupled with submerged microfiltration unit.Environ Sci Pollut Res Int. 2020 Apr 10;:Authors: Usman M, Katsoyiannis I, Rodrigues JH, Ernst MAbstract Arsenic is among the major drinking water contaminants...
10:52
Integrated care for the management of ageing-related non-communicable diseases: current gaps and future directions.: Related ArticlesIntegrated care for the management of ageing-related non-communicable diseases: current gaps and future directions.Aging Clin Exp Res. 2020 Apr 10;:Authors: Monaco A, Palmer K, Marengoni A, Maggi S, Hassan TA, Donde SAbstract Due to the increase in the older population in Europe and associated rise in the absolute number of persons with Non-Communicable Diseases...
10:52
Construction of lncRNA-associated ceRNA networks to identify prognostic lncRNA biomarkers for glioblastoma.: Related ArticlesConstruction of lncRNA-associated ceRNA networks to identify prognostic lncRNA biomarkers for glioblastoma.J Cell Biochem. 2020 Apr 10;:Authors: Liu Z, Wang X, Yang G, Zhong C, Zhang R, Ye J, Zhong Y, Hu J, Ozal B, Zhao SAbstract Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of...
10:51
Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia.: Related ArticlesMutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia.J Cell Mol Med. 2020 Apr 11;:Authors: Wu N, Zhang Z, Zhou X, Zhao H, Ming Y, Wu X, Zhang X, Yang XZ, Zhou M, Bao H, Chen W, Wu Y, Liu S, Wang H, Niu Y, Li Y, Zheng Y, Shao Y, Gao N, Yang Y, Liu Y, Li W, Liu J, Zhang N, Yang X, Xu Y, Li M, Sun Y, Su J, Zhang J, Xia W, Qiu G, Liu Y, Liu J, Wu ZAbstract...
10:51
Long noncoding RNA MEG3 decreases the growth of head and neck squamous cell carcinoma by regulating the expression of miR-421 and E-cadherin.: Related ArticlesLong noncoding RNA MEG3 decreases the growth of head and neck squamous cell carcinoma by regulating the expression of miR-421 and E-cadherin.Cancer Med. 2020 Apr 11;:Authors: Ji Y, Feng G, Hou Y, Yu Y, Wang R, Yuan HAbstract BACKGROUND: Maternally expressed 3 (MEG3), a long chain noncoding RNA (lncRNA), has verified its function as...
10:51
Daytime changes of salivary biomarkers involved in pain.: Related ArticlesDaytime changes of salivary biomarkers involved in pain.J Oral Rehabil. 2020 Apr 11;:Authors: Jasim H, Ghafouri B, Carlsson A, Hedenberg-Magnusson B, Ernberg MAbstract OBJECTIVES: The study aimed to investigate salivary levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), substance P (SP) and glutamate at five time-points from morning to afternoon in a well characterized healthy and pain-free...
10:50
Stent as a bridge to surgery or immediate colectomy for malignant right colonic obstruction: propensity-scored, national database study.: Related ArticlesStent as a bridge to surgery or immediate colectomy for malignant right colonic obstruction: propensity-scored, national database study.Br J Surg. 2020 Apr 11;:Authors: Sakamoto T, Fujiogi M, Lefor AK, Matsui H, Fushimi K, Yasunaga HAbstract BACKGROUND: The aim of this study was to compare perioperative outcomes of urgent colectomy and placement...
10:50
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.: Related ArticlesTransfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.Immunity. 2020 Apr 07;:Authors: Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang...
10:50
Vaccination against Allergy: A Paradigm Shift?: Related ArticlesVaccination against Allergy: A Paradigm Shift?Trends Mol Med. 2020 Apr;26(4):357-368Authors: Bachmann MF, Mohsen MO, Kramer MF, Heath MDAbstract Since the discovery that IgE antibodies mediate allergy, decades of research have unraveled complex mechanisms associated with conventional immunotherapy and the vital protagonists that shape 'immune tolerance' to allergens. Debate exists on what should constitute the dominant effector...
10:49
Does the Use of Cone-Beam Computed Tomography Before Mandibular Third Molar Surgery Impact Treatment Planning?: Related ArticlesDoes the Use of Cone-Beam Computed Tomography Before Mandibular Third Molar Surgery Impact Treatment Planning?J Oral Maxillofac Surg. 2020 Mar 13;:Authors: Baqain ZH, Al Hadidi A, AbuKaraky A, Khader YAbstract PURPOSE: We aimed to investigate whether cone-beam computed tomography (CBCT) alters the treatment decision for impacted mandibular third molar (M3M) surgery...
10:49
What do we know about the role of lipoprotein(a) in atherogenesis 57 years after its discovery?: Related ArticlesWhat do we know about the role of lipoprotein(a) in atherogenesis 57 years after its discovery?Prog Cardiovasc Dis. 2020 Apr 08;:Authors: Cybulska B, Kłosiewicz-Latoszek L, Penson PE, Banach MAbstract Elevated circulating concentrations of lipoprotein(a) [Lp(a)] is strongly associated with increased risk of atherosclerotic cardiovascular disease (CVD) and degenerative aortic stenosis....
10:49
Identification of proliferative diabetic retinopathy-associated genes on the protein-protein interaction network by using heat diffusion algorithm.: Related ArticlesIdentification of proliferative diabetic retinopathy-associated genes on the protein-protein interaction network by using heat diffusion algorithm.Biochim Biophys Acta Mol Basis Dis. 2020 Apr 08;:165794Authors: Zhang J, Zhang M, Zhao H, Xu XAbstract Diabetic retinopathy is a common complication of diabetes mellitus that causes...
10:48
The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.: Related ArticlesThe anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.Pharmacol Res. 2020 Apr 08;:104798Authors: Tamddoni A, Mohammadi E, Sedaghat F, Qujeq D, As'Habi AAbstract The mammalian target of rapamycin (mTOR) is a protein kinase that has been considered as a key regulator of a large number of cellular...
10:48
The pollution profiles and human exposure risks of chlorinated and brominated PAHs in indoor dusts from e-waste dismantling workshops: Comparison of GC-MS, GC-MS/MS and GC × GC-MS/MS determination methods.: Related ArticlesThe pollution profiles and human exposure risks of chlorinated and brominated PAHs in indoor dusts from e-waste dismantling workshops: Comparison of GC-MS, GC-MS/MS and GC × GC-MS/MS determination methods.J Hazard Mater. 2020 Mar 20;394:122573Authors: Tang J, Ma S, Liu R, Yue...
10:48
Ginsenoside Rg3 ameliorates acute exacerbation of COPD1 by suppressing neutrophil migration.: Related ArticlesGinsenoside Rg3 ameliorates acute exacerbation of COPD1 by suppressing neutrophil migration.Int Immunopharmacol. 2020 Apr 08;83:106449Authors: Guan X, Yuan Y, Wang G, Zheng R, Zhang J, Dong B, Ran N, Hsu AC, Wang C, Wang FAbstract Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is an irreversible inflammatory airways disease responsible for global health burden,...
10:47
Spatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters
Spatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters of Poyang Lake in China.: Related ArticlesSpatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters of Poyang Lake in China.Ecotoxicol Environ Saf. 2020 Apr 08;196:110543Authors: Liang X, Guan F, Chen B, Luo P, Guo C, Wu G, Ye Y, Zhou Q, Fang HAbstract Antibiotic resistance genes (ARGs) and antibiotics in the aquatic environment raise health concerns...
10:47
New insights into the release mechanism of Cd2+ from CdTe quantum dots within single cells in situ.: Related ArticlesNew insights into the release mechanism of Cd2+ from CdTe quantum dots within single cells in situ.Ecotoxicol Environ Saf. 2020 Apr 08;196:110569Authors: Zhao L, Guo Z, Wu H, Wang Y, Zhang H, Liu RAbstract Cadmium-quantum dots (Cd-QDs) possess unique properties as optoelectronic devices for sensitive detection in food and biomedicine fields. However, the toxic effects of Cd-QDs...
10:47
PM2.5-inducible long non-coding RNA (NONHSAT247851.1) is a positive regulator of inflammation through its interaction with raf-1 in HUVECs.: Related ArticlesPM2.5-inducible long non-coding RNA (NONHSAT247851.1) is a positive regulator of inflammation through its interaction with raf-1 in HUVECs.Ecotoxicol Environ Saf. 2020 Apr 08;196:110476Authors: Zhou C, Tan Y, Wang Y, Liao F, Wang Q, Li J, Peng S, Peng X, Zou YAbstract Several studies have demonstrated that PM2.5 inhalation is associated...
10:47
Citrinin exposure disrupts organelle distribution and functions in mouse oocytes.: Related ArticlesCitrinin exposure disrupts organelle distribution and functions in mouse oocytes.Environ Res. 2020 Apr 06;185:109476Authors: Sun MH, Li XH, Xu Y, Xu Y, Pan ZN, Sun SCAbstract Citrinin (CTN) is a secondary fungal metabolite produced by several species of Aspergillins and Penicillins, and it is widely found in vegetable-derived foods such as cereals and fermented rice-based food supplements. Previous...
10:46
Microplastics in mangrove sediments of the Pearl River Estuary, South China: Correlation with halogenated flame retardants' levels.: Related ArticlesMicroplastics in mangrove sediments of the Pearl River Estuary, South China: Correlation with halogenated flame retardants' levels.Sci Total Environ. 2020 Apr 03;725:138344Authors: Zuo L, Sun Y, Li H, Hu Y, Lin L, Peng J, Xu XAbstract Marine microplastic pollution of intertidal mangrove ecosystem is a matter of concern. However, the relationship...
10:45
Phage display-identified PD-L1-binding peptides reinvigorate T-cell activity and inhibit tumor progression.: Related ArticlesPhage display-identified PD-L1-binding peptides reinvigorate T-cell activity and inhibit tumor progression.Biomaterials. 2020 Mar 20;247:119984Authors: Gurung S, Khan F, Gunassekaran GR, Yoo JD, Poongkavithai Vadevoo SM, Permpoon U, Kim SH, Kim HJ, Kim IS, Han H, Park JH, Kim S, Lee BAbstract Blockade of programmed cell death ligand-1 (PD-L1) restores T-cell activity...
10:45
Management of locally advanced oral cancers.: Related ArticlesManagement of locally advanced oral cancers.Oral Oncol. 2020 Apr 08;105:104662Authors: Dhar H, Vaish R, D'Cruz AK, Vaish RAbstract Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion...
10:44
Presentation of new onset anosmia during the COVID-19 pandemic.: Related ArticlesPresentation of new onset anosmia during the COVID-19 pandemic.Rhinology. 2020 Apr 11;:Authors: Hopkins C, Surda P, Kumar NAbstract INTRODUCTION: Anosmia has not been formally recognised as a symptom of COVID-19 infection. Growing anecdotal evidence suggests increasing incidence of cases of anosmia during the current pandemic, suggesting that COVID-19 may cause olfactory dysfunction. The objective was to characterise...
10:44
Antibiotics, Vol. 9, Pages 175: Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods: Antibiotics, Vol. 9, Pages 175: Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance MethodsAntibiotics doi: 10.3390/antibiotics9040175Authors: Serrano Mitjana Bonastre Laborda Falceto García-Gonzalo Abilleira Elorduy Bousquet-Melou Mata ...
10:44
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease: Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington's disease (HD). Following our previous ...
10:43
Cancers, Vol. 12, Pages 953: High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer Patients: Cancers, Vol. 12, Pages 953: High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer PatientsCancers doi: 10.3390/cancers12040953Authors: Trebo Ditsch Kuhn Heidegger Zeder-Goess Kolben Czogalla Schmoeckel Mahner Jeschke Hester Galectins...
10:43
Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy: Publication date: Available online 11 April 2020Source: Journal of Controlled ReleaseAuthor(s): Jing Wang, Yuqi Wang, Haiqiang Cao, Hong Wang, Jie Li, Youxin Li, Yaping Li, Zhiwen Zhang
10:43
Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders: Publication date: Available online 11 April 2020Source: Journal of Controlled ReleaseAuthor(s): Raghavendra Upadhya, Winston Zingg, Siddhant Shetty, Ashok K. Shetty
10:42
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease: Publication date: Available online 11 April 2020Source: Free Radical Biology and MedicineAuthor(s): Jun Kai, Xiang Yang, Zhimin Wang, Feixia Wang, Yan Jia, Shijun Wang, Shanzhong Tan, Anping Chen, Jiangjuan Shao, Feng Zhang, Zili Zhang, Shizhong Zheng
10:42
Switch from intravenous or intramuscular to subcutaneous hepatitis B immunoglobulin: effect on quality of life after liver transplantation: Hepatitis B immunoglobulin (HBIG) therapy is available in intravenous (IV) or intra-muscular (IM) formulations. Recently, a subcutaneous (SC) formulation was introduced. This study evaluated changes in quality...
10:41
Bioremediation of potentially toxic metal and reactive dye-contaminated water by pristine and modified Chlorella vulgaris: AbstractThis is the first study on the biosorption of Cu2+ and reactive yellow 145 (RY145) dye by citric acid (CA), NaOH, and heat-treated Chlorella vulgaris (Cv). Influence of contact time, initial adsorptive concentration, and biomass dosage on the biosorption process was explored. The biosorption kinetics and isotherm were comprehensively investigated as well. The Fourier...
10:41
Craniofacial Reconstruction by a Cost-Efficient Template-Based Process Using 3D Printing: Craniofacial defects often result in aesthetic and functional deficits, which affect the patient's psyche and wellbeing. Patient-specific implants remain the optimal solution, but their use is limited or impractical due to their high costs. This article describes a fast and cost-efficient workflow of in-house manufactured patient-specific implants for craniofacial reconstruction and cranioplasty. As a proof...
10:41
Midostaurin: a magic bullet that blocks mast cell expansion and activation: Clinically relevant features in patients with systemic mastocytosis (SM) include the cosmetic burden of lesional skin, mediator-related symptoms, and organ damage resulting from mast cell (MC) infiltration in advanced forms of SM. Regardless of the SM variant, expansion of neoplastic MC in the skin and other organs is triggered by mutant forms of KIT, the most prevalent being D816V. Activation of MC with subsequent release...
10:40
Advances in the classification and treatment of mastocytosis: current status and outlook toward the future: Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis, systemic mastocytosis, and localized mast cell tumors. On the basis of histomorphologic criteria, clinical parameters,...
10:40
Proposed diagnostic criteria and classification of basophilic leukemias and related disorders: Basophils form a distinct cell lineage within the hematopoietic cell family. In various myeloid neoplasms, including chronic myeloid leukemia, basophilia is frequently seen. Acute and chronic basophilic leukemias, albeit rare, have also been described. However, no generally accepted criteria and classification of basophilic leukemias have been presented to date. To address this unmet need, a series of Working...
10:40
Downregulation of the Circadian Rhythm Regulator HLF Promotes Multiple-Organ Distant Metastases in Non-Small Cell Lung Cancer through PPAR/NF-κB Signaling: Publication date: Available online 11 April 2020Source: Cancer LettersAuthor(s): Jiarong Chen, Aibin Liu, Zhichao Lin, Bin Wang, Xingxing Chai, Shasha Chen, Wenjie Lu, Mingzhu Zheng, Ting Cao, Meigong Zhong, Ronggang Li, Minyan Wu, Zhuming Lu, Wenguang Pang, Wenhai Huang, Lin Xiao, Daren Lin, Zhihui Wang, Fangyong Lei, Xiangmeng Chen
10:40
Trastuzumab derived HER2-specific CARs for the treatment of trastuzumab-resistant breast cancer: CAR T cells penetrate and eradicate tumors that are not accessible to antibodies: Publication date: Available online 11 April 2020Source: Cancer LettersAuthor(s): Arpad Szoor, Gabor Toth, Barbara Zsebik, Viktoria Szabo, Zelig Eshhar, Hinrich Abken, Gyorgy Vereb
10:39
The effect of whole-body cryostimulation on body composition and leukocyte expression of HSPA1A, HSPB1, and CRP in obese men: Publication date: Available online 11 April 2020Source: CryobiologyAuthor(s): Wanda Pilch, Joanna Wyrostek, Piotr Major, Roxana Zuziak, Anna Piotrowska, Olga Czerwińska-Ledwig, Agata Grzybkowska, Mariusz Zasada, Ewa Ziemann, Małgorzata Żychowska
10:39
A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes: AbstractDBS is an effective neuromodulatory therapy that has been applied in various conditions, including PD, essential tremor, dystonia, Tourette syndrome, and other movement disorders. There have also been recent examples of applications in epilepsy, chronic pain, and neuropsychiatric conditions. Innovations in neuroimaging technology have been driving connectomics, an emerging whole‐brain network...
10:39
Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?: Publication date: Available online 11 April 2020Source: BiochimieAuthor(s): Elina Psara, Kristina Pentieva, Mary Ward, Helene McNulty
10:38
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles: Publication date: Available online 11 April 2020Source: BiochimieAuthor(s): Jean-Louis Guéant, Abderrahim Oussalah, Racha Zgheib, Youssef Siblini, Shyuefang Battaglia Hsu, Bernard Namour
10:38
Unusual dysphagia: Publication date: Available online 11 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): A. Schein, M. Garcier, A. Neuhart
10:37
Routine feasibility of postoperative chemoradiotherapy in head and neck squamous cell carcinoma at high risk of recurrence: Publication date: Available online 11 April 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): M. Humbert, M. De La Losa, B. Gery, C. Florescu, J. Thariat, A. RambeauAuthor links open overlay panelM.HumbertabM.De La LosaabB.GerycC.FlorescucJ.ThariatcdA.RambeaueaChirurgie ORL, Centre François-Baclesse, Caen, FrancebChirurgie ORL, Centre Hospitalier...
10:35
Cancers, Vol. 12, Pages 954: Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages: Cancers, Vol. 12, Pages 954: Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced StagesCancers doi: 10.3390/cancers12040954Authors: Florian Janke Farastuk Bozorgmehr Sabine Wrenger Steffen Dietz Claus P. Heussel Gudula Heussel Carlos F. Silva Stephan Rheinheimer Manuel Feisst Michael Thomas...
10:34
Clinical Trial Explores Azithromycin, Hydroxychloroquine Combo as COVID-19 Treatment: Rutgers Cancer Institute of New Jersey will be conducting a clinical trial assessing whether azithromycin combined with hydroxychloroquine is better than hydroxychloroquine alone as a potential treatment for patients diagnosed with COVID-19. (Source: CancerNetwork)
10:34
The secreted protein DEL-1 activates a {beta}3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration [Cell Biology]: The integrin-binding secreted protein developmental endothelial locus-1 (DEL-1) is involved in the regulation of both the initiation and resolution of inflammation in different diseases, including periodontitis, an oral disorder characterized by inflammatory bone loss. Here, using a mouse model of bone regeneration and in vitro cell-based mechanistic...
10:33
Alteration of the late endocytic pathway in Charcot–Marie–Tooth type 2B disease: AbstractThe small GTPase RAB7A regulates late stages of the endocytic pathway and plays specific roles in neurons, controlling neurotrophins trafficking and signaling, neurite outgrowth and neuronal migration. Mutations in the RAB7A gene cause the autosomal dominant Charcot–Marie–Tooth type 2B (CMT2B) disease, an axonal peripheral neuropathy. As several neurodegenerative diseases are caused by alterations of endocytosis,...
10:33
Cancers, Vol. 12, Pages 955: Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France): Cancers, Vol. 12, Pages 955: Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France)Cancers doi: 10.3390/cancers12040955Authors: Sandra Lassalle Véronique Hofman Simon Heeke ...
10:32
Clinical relevance of CYFRA 21-1 as a tumour marker in patients with oropharyngeal squamous cell carcinoma: AbstractBackgroundThe role of Cytokeratin fraction 21-1 (CYFRA 21-1) as a tumour marker for head and neck cancer is still a matter of research. The aim of the present study was to evaluate the clinical impact of CYFRA 21-1 for patients with oropharyngeal squamous cell carcinoma (OSCC).Patients and methodsData of 180 patients with an initial diagnosis of OSCC of any stage between 2003 and 2017...
10:31
Epstein‐Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country: ABSTRACTEpstein‐Barr virus (EBV) causes nasopharyngeal carcinoma (NPC) in endemic regions, where almost every tumor is EBV‐positive. In Western populations, NPC is rare, and human papillomavirus infection (HPV) has been suggested as another viral cause. We validated multiplex serology with molecular tumor markers, to define EBV‐positive, HPV‐positive, and EBV‐/HPV‐negative...
10:31
Actigraphy measurement of physical activity and energy expenditure in narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia: A Sensewear Armband study: AbstractThe cause of obesity in narcolepsy type 1 (NT1) patients is not fully understood. The present study investigated if a reduced physical activity could explain weight gain in NT1. Seventy‐nine patients were included in this retrospective study and divided into an NT1 group (n = 56) and a non‐NT1 group (n = 23), including NT2 and idiopathic...
10:31
Outcome analysis of stage I epithelial‐predominant favorable‐histology Wilms tumors: A report from Children's Oncology Group study AREN03B2Outcome analysis of stage I epithelial‐predominant favorable‐histology Wilms tumors: A report from Children's Oncology Group study AREN03B2: BackgroundStage I epithelial‐predominant favorable‐histology Wilms tumors (EFHWTs) have long been suspected to have an excellent outcome. This study investigates the clinical and pathologic features of patients with stage...
Fri Apr 10, 2020 10:38
Outcome analysis of stage I epithelial‐predominant favorable‐histology Wilms tumors: A report from Children's Oncology Group study AREN03B2: BackgroundStage I epithelial‐predominant favorable‐histology Wilms tumors (EFHWTs) have long been suspected to have an excellent outcome. This study investigates the clinical and pathologic features of patients with stage I EFHWTs to better evaluate the potential for a reduction of chemotherapy and its associated toxicity.MethodsAll patients registered in the...
Fri Apr 10, 2020 10:32
Phase I study of lapatinib plus trametinib in patients with KRAS -mutant colorectal, non-small cell lung, and pancreatic cancer: AbstractPurposeKRAS oncogene mutations cause sustained signaling through the MAPK pathway. Concurrent inhibition of MEK, EGFR, and HER2 resulted in complete inhibition of tumor growth in KRAS-mutant (KRASm) and PIK3CA wild-type tumors, in vitro and in vivo. In this phase I study, patients with advanced KRASm and PIK3CA wild-type colorectal cancer (CRC), non-small cell lung...
Fri Apr 10, 2020 10:31
Cancers, Vol. 12, Pages 934: Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 Mutations: Cancers, Vol. 12, Pages 934: Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 MutationsCancers doi: 10.3390/cancers12040934Authors: Adrián Segura-Díaz Ruth Stuckey Yanira Florido Jesús María González-Martín Juan Francisco López-Rodríguez Santiago Sánchez-Sosa Elena González-Pérez María Nieves...
Fri Apr 10, 2020 10:31
Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects: AbstractBackground and ObjectivePeficitinib pharmacokinetics and pharmacodynamics have been characterized mainly in Caucasian subjects. This study investigated the pharmacokinetics, pharmacodynamics, safety, and tolerability of peficitinib in healthy Japanese subjects compared with Caucasian subjects.MethodsIn this single-center, randomized, double-blind, placebo-controlled study,...
Fri Apr 10, 2020 10:31
Spectroscopic, quantum mechanical studies, ligand protein interactions and photovoltaic efficiency modeling of some bioactive benzothiazolinone acetamide analogs: AbstractIn the present work, the molecules, N-(4-chlorophenyl)-2-[6-(benzoyl)-2-benzothiazolinone-3-yl]acetamide (CBBA), N-(6-methyl-2-pyridyl)-2-[6-(2-chlorobenzoyl)-2-benzothiazolinone-3-yl]acetamide (MCBA), N-(3-Chlorophenyl)-2-[6-(2-fluorobenzoyl)-2-benzothiazolinone-3-yl]acetamide (CFBA) and N-(6-methyl-2-pyridyl)-2-[6-(2-fluorobenzoyl)-2-benzothiazolinone-3-yl]acetamide...
Fri Apr 10, 2020 10:30
Phase I study of lapatinib plus trametinib in patients with KRAS -mutant colorectal, non-small cell lung, and pancreatic cancer: AbstractPurposeKRAS oncogene mutations cause sustained signaling through the MAPK pathway. Concurrent inhibition of MEK, EGFR, and HER2 resulted in complete inhibition of tumor growth in KRAS-mutant (KRASm) and PIK3CA wild-type tumors, in vitro and in vivo. In this phase I study, patients with advanced KRASm and PIK3CA wild-type colorectal cancer (CRC), non-small cell lung...
Fri Apr 10, 2020 10:30
Antibiotics, Vol. 9, Pages 168: Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to Improve: Antibiotics, Vol. 9, Pages 168: Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to ImproveAntibiotics doi: 10.3390/antibiotics9040168Authors: Beatrice Tiri Paolo Bruzzone Giulia Priante Emanuela Sensi Monya Costantini Carlo Vernelli Lucia Assunta Martella Marsilio...
Fri Apr 10, 2020 10:30
Excessive Leukocytosis Leading to a Diagnosis of Aggressive Thyroid Anaplastic Carcinoma: A Case Report and Relevant Review: Introduction: Leukocytosis and particularly neutrophilia are usually caused by acute infection, inflammation, and myeloproliferative neoplasms. However, leukocytosis can also occur in patients with malignancy either due to bone marrow metastases or in the context of a paraneoplastic syndrome. Case Presentation: An 86-year-old female was admitted to our hospital due to marked...
Fri Apr 10, 2020 10:29
An Update on Regional Nodal Irradiation: Indication, Target Volume Delineation, and Radiotherapy Techniques: Background: Tremendous changes have occurred in the treatment of breast cancer. This paper reviews and unifies the available data on modern axillary management of breast cancer patients with focus on the target volume delineation for regional nodal irradiation according to the most important contouring guidelines, the European Society for Radiotherapy and Oncology (ESTRO) and the Radiation...
Fri Apr 10, 2020 10:29
Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: Undifferentiated pleomorphic sarcoma (UPS) was previously known as malignant fibrous histiocytoma (MFH). This sarcoma occurs preferentially in the extremities and retroperitoneal space; primary pulmonary UPS/MFH is rare. We report a 52-year-old woman referred to our hospital with dyspnea and severe cough. Chest computed tomography (CT) revealed a pulmonary mass in the left upper lobe and...
Fri Apr 10, 2020 10:28
Novel biomarkers for the evaluation of aging-induced proteinopathies: AbstractProteinopathies are characterized by aging related accumulation of misfolded protein aggregates. Irreversible covalent modifications of aging proteins may significantly affect the native three dimentional conformation of proteins, alter their function and lead to accumulation of misfolded protein as dysfunctional aggregates. Protein misfolding and accumulation of aberrant proteins are known to be associated with aging-induced...
Fri Apr 10, 2020 10:28
Gastrostomy in Patients with Previous Abdominal Surgery: A Comparative Study Between the Laparoscopy-Assisted Introducer Percutaneous Endoscopic Gastrostomy Versus Open Gastrostomy in Advanced Esophageal Cancer: AbstractStraightened nutritional status plays a vital role in the treatment outcome of advanced esophageal cancer. Both introducer percutaneous endoscopic gastrostomy (PEG) and open gastrostomy are safe options with avoidance risk of cancer cell seeding. The introducer PEG is an effective...
Fri Apr 10, 2020 10:28
A Case of Advanced Hepatocellular Carcinoma with Partial Response after Continuous Ramucirumab Treatment beyond Radiological Progression: A 73-year-old male was initially treated with sorafenib for advanced stage HCC. However, the disease progressed 2 months after starting sorafenib. Progressive disease (PD) was confirmed by radiological examination, which revealed mediastinal and abdominal lymph node metastasis, pulmonary metastasis, and intrahepatic recurrence. The patient was enrolled in the REACH-2...
Fri Apr 10, 2020 10:28
Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy: We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. The patient was a 62-year-old woman with a chief complaint...
Fri Apr 10, 2020 10:28
A Case of Solitary Lung Metastasis of Breast Cancer Successfully Treated with Stereotactic Body Radiotherapy after Chemotherapy: A 62-year-old woman with triple-negative breast cancer underwent breast-conserving surgery followed by adjuvant chemotherapy and radiotherapy to the breast. The patient developed a solitary lung metastasis at the left hilum 44 months after the operation. The lung metastasis responded partially to capecitabine chemotherapy, but showed regrowth in 7 months. The patient received...
Fri Apr 10, 2020 10:27
Renal Squamous Cell Carcinoma with Staghorn Calculus: A 70-year-old Japanese woman was referred to our department due to general fatigue and a persistent low fever. We performed percutaneous nephrostomy and administered antibiotics for the pyelonephritis due to her left staghorn calculus. After the infection had been brought under control and her general condition improved, we performed nephrectomy. A pathologic examination revealed renal squamous cell carcinoma (SCC) in addition to xanthogranulomatous...
Fri Apr 10, 2020 10:27
Three Curative Pancreatectomies for the Metachronous Appearance of Pancreatic Invasive Ductal Adenocarcinoma: We report a rare case of a patient who underwent 3 successful curative operations for the metachronous appearance of pancreatic cancer. In July 2007, a 54-year-old woman underwent pylorus-preserving pancreaticoduodenectomy. In March 2010, a tumor measuring 9 mm in diameter was detected in the tail of the pancreas on computed tomography (CT) and magnetic resonance imaging. The pancreas tail...
Fri Apr 10, 2020 10:27
Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis: ABSTRACTTo date, no systematic analyses are available assessing concordance of molecular classifications between primary tumors (PT) and matched liver metastases (LM) of metastatic colorectal cancer (mCRC). We investigated concordsssance between PT and LM for four clinically relevant CRC gene signatures. Twenty‐seven fresh and 55 formalin fixed paraffin embedded pairs of...
Fri Apr 10, 2020 10:26
Immune‐related pancytopenia caused by nivolumab and ipilimumab combination therapy for unresectable melanoma of unknown primary:
Fri Apr 10, 2020 10:26
BCMA‐specific chimeric antigen receptor T cells for multiple myeloma: Clinical experience and future perspectives: AbstractDespite major advances in the treatment of multiple myeloma (MM) it remains a largely incurable disease with long‐term control often dependent on continuous therapy. More effective, better tolerated treatments are therefore required to achieve durable remissions and to improve the quality of life of MM patients. Adoptive immunotherapy employing T‐cells expressing chimeric antigen...
Fri Apr 10, 2020 10:26
Neoadjuvant chemotherapy followed by surgery in lung cancer: Indian scenario.: Related ArticlesNeoadjuvant chemotherapy followed by surgery in lung cancer: Indian scenario.Curr Probl Cancer. 2020 Mar 04;:100563Authors: Kumar S, Saikia J, Kumar V, Malik PS, Madan K, Jain D, Bharati SAbstract A vast majority of the patients with lung cancer in India present as advanced stage disease and a significant number among them have nonmetastatic locally advanced tumors which require multimodality management...
Fri Apr 10, 2020 10:25
Wearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram.: Related ArticlesWearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram.Sensors (Basel). 2020 Apr 04;20(7):Authors: Klum M, Urban M, Tigges T, Pielmus AG, Feldheiser A, Schmitt T, Orglmeister...
Fri Apr 10, 2020 10:25
Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy.: Related ArticlesInflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy.J Clin Med. 2020 Apr 05;9(4):Authors: Huang YS, Chin WC, Guilleminault C, Chu KC, Lin CH, Li HYAbstract BACKGROUND: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before...
Fri Apr 10, 2020 10:25
The firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors.: Related ArticlesThe firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors.J Neurosci. 2020 Mar 30;:Authors: Ma X, Zhang Y, Wang L, Li N, Barkai E, Zhang X, Lin L, Xu JAbstract The septo-hippocampal cholinergic system is critical for hippocampal learning and memory. However, a quantitative description...
Fri Apr 10, 2020 10:24
#
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Telephone consultation 11855 int 1193,
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου