Στην βιολογία, το περιβάλλον μπορεί να καθοριστεί σαν ενα σύνολο κλιματικών, βιοτικών, κοινωνικών και εδαφικών παραγόντων που δρουν σε έναν οργανισμό και καθορίζουν την ανάπτυξη και την επιβίωση του. Έτσι, περιλαμβάνει οτιδήποτε μπορεί να επηρεάσει άμεσα τον μεταβολισμό ή τη συμπεριφορά των ζωντανών οργανισμών ή ειδών, όπως το φως, ο αέρας, το νερό, το έδαφος και άλλοι παράγοντες. Δείτε επίσης το άρθρο για το φυσικό περιβάλλον και τη φυσική επιλογή.
Στην αρχιτεκτονική, την εργονομία και την ασφάλεια στην εργασία, περιβάλλον είναι το σύνολο των χαρακτηριστικών ενός δωματίου ή κτιρίου που επηρεάζουν την ποιότητα ζωής και την αποδοτικότητα, περιλαμβανομένων των διαστάσεων και της διαρρύθμισης των χώρων διαβίωσης και της επίπλωσης, του φωτισμού, του αερισμού, της θερμοκρασίας, του θορύβου κλπ. Επίσης μπορεί να αναφέρεται στο σύνολο των δομικών κατασκευών. Δείτε επίσης το άρθρο για το δομημένο περιβάλλον.
Στην ψυχολογία, περιβαλλοντισμός είναι η θεωρία ότι το περιβάλλον (με τη γενική και κοινωνική έννοια) παίζει μεγαλύτερο ρόλο από την κληρονομικότητα καθορίζοντας την ανάπτυξη ενός ατόμου. Συγκεκριμένα, το περιβάλλον είναι ένας σημαντικός παράγοντας πολλών ψυχολογικών θεωριών.
Στην τέχνη, το περιβάλλον αποτελεί κινητήριο μοχλό και μούσα εμπνέοντας τους ζωγράφους ή τους ποιητές. Σε όλες τις μορφές της Τέχνης αποτελεί έμπνευση και οι Καλές Τέχνες φανερώνουν την επιρροή οπού άσκησε σε όλους τους καλλιτέχνες με όποιο είδος Τέχνης κι αν ασχολούνται. Ο άνθρωπος μέσα στο περιβάλλον δημιουργεί Μουσική, Ζωγραφική, Ποίηση, Γλυπτική, χορό, τραγούδι, θέατρο, αλλά και όλες οι μορφές τέχνης έχουν άμεση έμπνευση από το περιβάλλον.

Παρασκευή 18 Σεπτεμβρίου 2020

Medicine by Alexandros G. Sfakianakis

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Serum IL-6 as a prognostic biomarker and IL-6R as a therapeutic target in biliary tract cancers.: Related ArticlesSerum IL-6 as a prognostic biomarker and IL-6R as a therapeutic target in biliary tract cancers.Clin Cancer Res. 2020 Sep 15;:Authors: Hogdall DTS, O'Rourke CJ, Dehlendorff C, Larsen FO, Jensen LH, Johansen AZ, Dang H, Factor VM, Grunnet M, Mau-Sørensen M, Oliveira DVNP, Linnemann D, Boisen MK, Wang XW, Johansen JS, Andersen JBAbstract PURPOSE: Biliary tract cancers (BTC) are...
Pathophysiology and Imaging Findings of Bile Duct Necrosis: A Rare but Serious Complication of Transarterial Therapy for Liver Tumors.: Related ArticlesPathophysiology and Imaging Findings of Bile Duct Necrosis: A Rare but Serious Complication of Transarterial Therapy for Liver Tumors.Cancers (Basel). 2020 Sep 11;12(9):Authors: Kobayashi S, Kozaka K, Gabata T, Matsui O, Koda W, Okuda M, Okumura K, Sugiura T, Ogi TAbstract Bile duct necrosis (BDN) with biloma formation is a type of ischemic...
[Complex treatment of a patient with neurofibromatosis type 2].: Related Articles[Complex treatment of a patient with neurofibromatosis type 2].Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8):98-104Authors: Rynda AY, Olyushin VE, Rostovtsev DM, Zabrodskaya YMAbstract Neurofibromatosis type 2, a rare disease, the most characteristic manifestation of which is the presence of bilateral vestibular schwannomas, less often schwannomas of other cranial, spinal and peripheral nerves. Much less...
Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion.: Related ArticlesEfficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion.Oncology. 2020;98(9):621-629Authors: Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro MAbstract INTRODUCTION: Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence...
Risk factors and oncological outcomes of urethral recurrence in male patients with muscle invasive bladder cancer after radical cystectomy combined with urinary diversion: a propensity score-matched case control study.: Related ArticlesRisk factors and oncological outcomes of urethral recurrence in male patients with muscle invasive bladder cancer after radical cystectomy combined with urinary diversion: a propensity score-matched case control study.Int J Clin Oncol. 2020 Jul;25(7):1377-1384Authors:...
Comparative genomic profiling of glandular bladder tumours.: Related ArticlesComparative genomic profiling of glandular bladder tumours.Virchows Arch. 2020 Sep;477(3):445-454Authors: Maurer A, Ortiz-Bruechle N, Guricova K, Rose M, Morsch R, Garczyk S, Stöhr R, Bertz S, Golz R, Reis H, Bremmer F, Zimpfer A, Siegert S, Kristiansen G, Schwamborn K, Gassler N, Knuechel R, Gaisa NT, German study group of bladder cancerAbstract Primary glandular bladder tumours (bladder adenocarcinoma [BAC],...
Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing.: Related ArticlesNovel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing.Virchows Arch. 2020 Sep;477(3):455-459Authors: Lu Y, He X, Qiu Y, Chen H, Zhuang H, Yao J, Zhang HAbstract Intravascular fasciitis (IVF) is considered a rare variant of nodular fasciitis, which often involves small- and medium-sized blood vessels. Approximately...
Uniportal VATS right superior lobectomy: management of pulmonary vein variation: a case report.: Related ArticlesUniportal VATS right superior lobectomy: management of pulmonary vein variation: a case report.J Cardiothorac Surg. 2020 Feb 27;15(1):45Authors: Wang Z, Sun Y, Zhang Q, Shao FAbstract BACKGROUND: Although there are lots of variations of pulmonary veins including dangerous type that could cause serious complications during surgery, limited information has been reported about...
MYC amplification on double minute chromosomes in plasma cell leukemia with double IGH/CCND1 fusion genes.: Related ArticlesMYC amplification on double minute chromosomes in plasma cell leukemia with double IGH/CCND1 fusion genes.Cancer Genet. 2020 04;242:35-40Authors: Yamamoto K, Yakushijin K, Ito M, Goto H, Higashime A, Kajimoto K, Hayashi Y, Matsuoka H, Minami HAbstract In multiple myeloma (MM), MYC rearrangements that result in increased MYC expression are associated with an aggressive...
Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review.: Related ArticlesCutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review.Diagn Pathol. 2020 Jan 31;15(1):7Authors: Luong TMH, Akazawa Y, Mussazhanova Z, Matsuda K, Ueki N, Miura S, Hara T, Yokoyama H, Nakashima MAbstract BACKGROUND: Cutaneous pilomatrical carcinosarcoma (CS) is a very rare biphasic tumor composed of admixed epithelial and mesenchymal...
The snoring 2-year-old boy: a case of primary nasopharyngeal Burkitt's lymphoma.: Related ArticlesThe snoring 2-year-old boy: a case of primary nasopharyngeal Burkitt's lymphoma.BMJ Case Rep. 2020 Jan 23;13(1):Authors: Xuereb G, Borg J, Apap K, Borg CAbstract Sporadic Burkitt's lymphoma affecting the nasopharyngeal region is an extremely rare disease, especially in infants. We describe the case of a 2-year-old boy who presented to the ear, nose and throat department with a history of snoring,...
Pancreatic metastasis of dermatofibrosarcoma protuberans: a rare case.: Related ArticlesPancreatic metastasis of dermatofibrosarcoma protuberans: a rare case.BMJ Case Rep. 2020 Jan 23;13(1):Authors: Chilukuri DS, Premkumar P, Venkitaraman B, Soundararajan JCBAbstract Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue malignancy which is locally aggressive, slow growing. It has a very low metastatic potential and has high risk of local recurrence. We report a 65-year-old man with...
Curious case of myxoid adipocytic tumour with ureteropelvic junction obstruction in horseshoe kidney: dilemma in management.: Related ArticlesCurious case of myxoid adipocytic tumour with ureteropelvic junction obstruction in horseshoe kidney: dilemma in management.BMJ Case Rep. 2020 Jan 23;13(1):Authors: Nayyar R, Kumar P, Barwad AW, Saini SAbstract Isolated renal involvement by myxoid adipocytic tumour is a very rare presentation. We are reporting a horseshoe kidney with ureteropelvic...
Mediastinal metastatic melanoma: an unusual case presentation of recurrent melanoma.: Related ArticlesMediastinal metastatic melanoma: an unusual case presentation of recurrent melanoma.BMJ Case Rep. 2020 Jan 22;13(1):Authors: Joyce C, Konrade E, Kenyon JWAbstract Mediastinal malignant melanoma is rare as both primary and metastatic lesions. We present the case of a 50-year-old man with diagnosis of recurrent melanoma of the mediastinum. Our patient was previously treated for cutaneous...
Extramammary Paget's disease: what do we know and how do we treat?: Related ArticlesExtramammary Paget's disease: what do we know and how do we treat?Can J Urol. 2019 Dec;26(6):10012-10021Authors: Adashek JJ, Leonard A, Nealon SW, Krishnan A, Mosiello GC, Dhillon J, Spiess PEAbstract INTRODUCTION: Extramammary Paget's disease (EMPD) is a rare and complex condition, for which no established guidelines exist regarding diagnosis and management. There have been recent improvements in the diagnosis...
Clinical characteristics, diagnosis, treatment, and prognostic factors of pulmonary mucosa-associated lymphoid tissue-derived lymphoma.: Related ArticlesClinical characteristics, diagnosis, treatment, and prognostic factors of pulmonary mucosa-associated lymphoid tissue-derived lymphoma.Cancer Med. 2019 12;8(18):7660-7668Authors: Wang L, Ye G, Liu Z, Shi L, Zhan C, Gu J, Luo R, Lin Z, Ge D, Wang QAbstract Primary pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma is a...
PRODIGY: personalized prioritization of driver genes.: Related ArticlesPRODIGY: personalized prioritization of driver genes.Bioinformatics. 2020 03 01;36(6):1831-1839Authors: Dinstag G, Shamir RAbstract MOTIVATION: Evolution of cancer is driven by few somatic mutations that disrupt cellular processes, causing abnormal proliferation and tumor development, whereas most somatic mutations have no impact on progression. Distinguishing those mutated genes that drive tumorigenesis in a patient...
Immune checkpoint inhibitor-associated pituitary-adrenal dysfunction: A systematic review and meta-analysis.: Related ArticlesImmune checkpoint inhibitor-associated pituitary-adrenal dysfunction: A systematic review and meta-analysis.Cancer Med. 2019 12;8(18):7503-7515Authors: Lu J, Li L, Lan Y, Liang Y, Meng HAbstract With the growing use of immune checkpoint inhibitors (ICIs), case reports of rare yet life-threatening pituitary-adrenal dysfunctions, particularly for hypopituitarism,...
Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT.: Related ArticlesHypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT.Cancer Med. 2019 12;8(18):7822-7832Authors: Yoshimoto S, Tanaka F, Morita H, Hiraki A, Hashimoto SAbstract Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart...
Helical tomotherapy for chemo-refractory multiple liver metastases.: Related ArticlesHelical tomotherapy for chemo-refractory multiple liver metastases.Cancer Med. 2019 12;8(18):7594-7602Authors: Takaoka T, Shibamoto Y, Murai T, Kobayashi M, Sugie C, Manabe Y, Kondo T, Okazaki D, Yamada Y, Torii AAbstract BACKGROUND: Despite advances in chemotherapy, curing multiple liver metastases is quite rare. Even when response is obtained, regrowth of the tumors is almost inevitable. We aimed to...
Targeted RNA-sequencing assays: a step forward compared to FISH and IHC techniques?: Related ArticlesTargeted RNA-sequencing assays: a step forward compared to FISH and IHC techniques?Cancer Med. 2019 12;8(18):7556-7566Authors: Tachon G, Cortes U, Richard S, Martin S, Milin S, Evrard C, Lamour C, Karayan-Tapon LAbstract INTRODUCTION: ALK and ROS1 rearrangements are molecular targets of several tyrosine kinase inhibitors. RNA-sequencing approaches are regarded as the new standard for fusion...
Prognosis in triple-negative apocrine carcinomas of the breast: A population-based study.: Related ArticlesPrognosis in triple-negative apocrine carcinomas of the breast: A population-based study.Cancer Med. 2019 12;8(18):7523-7531Authors: Wu W, Wu M, Peng G, Shi D, Zhang JAbstract BACKGROUND: Triple-negative apocrine carcinoma (TNAC) of the breast is a very rare type of breast cancer. Furthermore, the clinicopathological features, prognosis, and potential impact of treatment strategies...
[Infant with intracranial calcifications and retinopathy].: Related Articles[Infant with intracranial calcifications and retinopathy].Rev Neurol. 2019 Oct 01;69(7):289-292Authors: Hidalgo-Sanz J, Perez-Delgado R, Garcia-Jimenez I, Lopez-Pison J, Castillo-Castejon O, Poch ML, Izquierdo-Alvarez SAbstract INTRODUCTION: Intracranial calcifications can have a number of different causes, and the distribution and characteristics they present in neuroimaging can orient the specialist towards one...
Genetic Markers of the Host to Predict the Efficacy of Colorectal Cancer Targeted Therapy.: Related ArticlesGenetic Markers of the Host to Predict the Efficacy of Colorectal Cancer Targeted Therapy.Curr Med Chem. 2020;27(25):4249-4273Authors: De Mattia E, Bignucolo A, Toffoli G, Cecchin EAbstract The introduction of anti-EGFR (cetuximab and panitumumab) and antiangiogenic (bevacizumab, regorafeninb, ramucirumab, and aflibercept) agents in the therapeutic armamentarium of the metastatic colorectal...
Association Between Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Risk and Polyurethane Breast Implants: Clinical Evidence and European Perspective.: Related ArticlesAssociation Between Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Risk and Polyurethane Breast Implants: Clinical Evidence and European Perspective.Aesthet Surg J. 2019 01 31;39(Suppl_1):S49-S54Authors: Hamdi MAbstract This article aims to present an overview on the use of polyurethane...
Brain α-Tocopherol Concentration and Stereoisomer Profile Alter Hippocampal Gene Expression in Weanling Mice.: Brain α-Tocopherol Concentration and Stereoisomer Profile Alter Hippocampal Gene Expression in Weanling Mice.J Nutr. 2020 Sep 16;:Authors: Rhodes JS, Rendeiro C, Mun JG, Du K, Thaman P, Snyder A, Pinardo H, Drnevich J, Chandrasekaran S, Lai CS, Schimpf KJ, Kuchan MJAbstract BACKGROUND: Alpha-tocopherol (αT), the bioactive constituent of vitamin E, is essential for fertility and...
Rapeseed Lecithin Increases Lymphatic Lipid Output and α-Linolenic Acid Bioavailability in Rats.: Rapeseed Lecithin Increases Lymphatic Lipid Output and α-Linolenic Acid Bioavailability in Rats.J Nutr. 2020 Sep 16;:Authors: Robert C, Couëdelo L, Knibbe C, Fonseca L, Buisson C, Errazuriz-Cerda E, Meugnier E, Loizon E, Vaysse C, Michalski MCAbstract BACKGROUND: Soybean lecithin, a plant-based emulsifier widely used in food, is capable of modulating postprandial lipid metabolism. With arising...
Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age.: Association of Serum 25-Hydroxyvitamin D Deficiency with Risk of Incidence of Disability in Basic Activities of Daily Living in Adults >50 Years of Age.J Nutr. 2020 Sep 16;:Authors: Luiz MM, Máximo R, Oliveira DC, Ramírez PC, de Souza AF, Delinocente MLB, Steptoe A, de Oliveira C, Alexandre TAbstract BACKGROUND: Vitamin D deficiency...
1Review Anticancer Drugs. 2019 Oct;30(9):879-885. doi: 10.1097/CAD.0000000000000832.A review of canakinumab and its therapeutic potential for non-small cell lung cancerKara M Schenk 1, Joshua E Reuss 1, Karin Choquette 2 3, Alexander I Spira 1 2 3Affiliations expandPMID: 31503012 DOI: 10.1097/CAD.0000000000000832AbstractInflammation is essential for our innate and adaptive immunity, but chronic inflammation can also be detrimental, playing a role in tumor development and subversion of host immunity....
Nephronectin is a prognostic biomarker and promotes gastric cancer cell proliferation, migration and invasion.: Related ArticlesNephronectin is a prognostic biomarker and promotes gastric cancer cell proliferation, migration and invasion.Histol Histopathol. 2020 Sep 16;:18260Authors: Mei D, Zhao B, Zhang J, Xu H, Huang BAbstract Gastric cancer (GC) is a malignant disease with high incidence and mortality rates worldwide. Nephronectin (NPNT) was found to be dysregulated in some kinds of cancer....
Headaches in hypermobility syndromes: A pain in the neck?: AbstractHeadache and neck pain (cervicalgia) are frequently reported among patients with joint hypermobility but the prevalence and scope of these symptoms has not been studied in the era of contemporary Ehlers‐Danlos and hypermobility disorder nosology. We performed a single‐center retrospective study on the incidence of head and neck symptoms in 140 patients with hypermobility disorders over a 2‐year period. Overall, 93 patients (66%) reported...
The association of telomere length with substance use disorders: systematic review and meta-analysis protocol.: Related ArticlesThe association of telomere length with substance use disorders: systematic review and meta-analysis protocol.Syst Rev. 2019 12 01;8(1):298Authors: Navarro-Mateu F, Rubio-Aparicio M, Cayuela P, Álvarez FJ, Roca-Vega A, Chirlaque MD, Cayuela ML, Husky M, Martínez S, Sánchez-Meca JAbstract BACKGROUND: The present protocol was designed for a systematic review and...
Delayed Reconstruction with Full-Thickness Skin Grafts Following Defect Size Reduction in Head and Neck Nonmelanoma Skin Cancer.: Delayed Reconstruction with Full-Thickness Skin Grafts Following Defect Size Reduction in Head and Neck Nonmelanoma Skin Cancer.Facial Plast Surg. 2020 Sep 16;:Authors: Sezgin B, Kaya I, Turhal G, Apaydin FAbstract Different treatment modalities have been applied for nonmelanoma skin cancers (NMSCs) of the head and neck area. One of the most important points...
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.: Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.Sci Adv. 2020 Jul 31;6(31):Authors: Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, Chance R, Macaulay IC, Chou HJ, Fletcher RB, Das D, Street K, de Bezieux HR, Choi YG, Risso D, Dudoit S, Purdom E, Mill J, Hachem...
ASPM-lexical tone association in speakers of a tone language: Direct evidence for the genetic-biasing hypothesis of language evolution.: ASPM-lexical tone association in speakers of a tone language: Direct evidence for the genetic-biasing hypothesis of language evolution.Sci Adv. 2020 May;6(22):Authors: Wong PCM, Kang X, Wong KHY, So HC, Choy KW, Geng XAbstract How language has evolved into more than 7000 varieties today remains a question that puzzles linguists, anthropologists, and evolutionary...
Symptom clusters in head and neck cancer patients with endotracheal tube: Which symptom clusters are independently associated with health-related quality of life?: Symptom clusters in head and neck cancer patients with endotracheal tube: Which symptom clusters are independently associated with health-related quality of life?Eur J Oncol Nurs. 2020 Aug 05;48:101819Authors: Li Y, Li X, Mao C, Lv G, Xie Z, Jiang H, Li PAbstract PURPOSE: The point of view of symptom clusters (SCs) may develop...
Validation of the Chinese version of chemotherapy-induced Taste Alteration Scale among patients with head and neck cancer undergoing radiotherapy.: Validation of the Chinese version of chemotherapy-induced Taste Alteration Scale among patients with head and neck cancer undergoing radiotherapy.Eur J Oncol Nurs. 2020 Aug 06;48:101818Authors: Wang Y, Zhang L, Lu Q, Li H, Jin S, Cui H, Wang Y, Gong L, Jin S, Cao Y, Shih YAbstract PURPOSE: To validate the Chinese version of the Chemotherapy-induced...
Metastatic lung adenocarcinoma mimicking Richter transformation in a patient with chronic lymphocytic leukemia.: Metastatic lung adenocarcinoma mimicking Richter transformation in a patient with chronic lymphocytic leukemia.Leuk Res. 2020 Sep 13;98:106445Authors: Cherng HJ, Jain N, Thakral B, Muzzafar T, Miranda RN, Tan D, Rashid A, Kalhor N, Hahn AW, Byers LA, Parseghian CM, Ferrajoli A, Pemmaraju NPMID: 32937250 [PubMed - as supplied by publisher]View allRichter's syndrome (RS), also known as Richter's...
Tolerance of Continuous Positive Airway Pressure After Sinonasal Surgery.: Related ArticlesTolerance of Continuous Positive Airway Pressure After Sinonasal Surgery.Laryngoscope. 2020 Sep 16;:Authors: Reilly EK, Boon MS, Vimawala S, Chitguppi C, Patel J, Murphy K, Doghramji K, Nyquist GG, Rosen MR, Rabinowitz MR, Huntley CTAbstract OBJECTIVES/HYPOTHESIS: For patients with obstructive sleep apnea (OSA) undergoing sinonasal surgery, there is a lack of consensus on the risk and appropriate...
Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.: Related ArticlesCombined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models.Radiat Res. 2020 Sep 16;:Authors: Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben DAbstract Head and neck squamous cell carcinoma (HNSCC) is a challenging cancer with little change in five-year overall survival rate of 50-60% over the...
A double-blind phase III trial of immunomodulating nutritional formula during adjuvant chemoradiotherapy in head and neck cancer patients: IMPATOX.: Related ArticlesA double-blind phase III trial of immunomodulating nutritional formula during adjuvant chemoradiotherapy in head and neck cancer patients: IMPATOX.Am J Clin Nutr. 2020 Sep 16;:Authors: Boisselier P, Kaminsky MC, Thézenas S, Gallocher O, Lavau-Denes S, Garcia-Ramirez M, Alfonsi M, Cupissol D, de Forges H, Janiszewski C, Geoffrois L, Sire...
Pathologist-performed palpation-guided fine needle aspiration cytology of lingual actinomycosis: A case report and review of literature.: Related ArticlesPathologist-performed palpation-guided fine needle aspiration cytology of lingual actinomycosis: A case report and review of literature.Diagn Cytopathol. 2020 Sep 16;:Authors: Özcan Z, Aker FV, Gölcük VAAbstract "Lingual actinomycosis" is an uncommon, suppurative inflammation of lingual mucosa, caused by Actinomyces. Infectious oral lesions...
Superior turbinate management and olfactory outcome after endoscopic endonasal transsphenoidal surgery for pituitary adenoma: a propensity score-matched cohort study.: Related ArticlesSuperior turbinate management and olfactory outcome after endoscopic endonasal transsphenoidal surgery for pituitary adenoma: a propensity score-matched cohort study.Int Forum Allergy Rhinol. 2020 Sep 16;:Authors: Li P, Luo K, Zhang Q, Wang ZAbstract BACKGROUND: Surgical management of the superior turbinate...
CT Features of Post-Traumatic Visual Loss.: Related ArticlesCT Features of Post-Traumatic Visual Loss.AJR Am J Roentgenol. 2020 Sep 16;:Authors: Ibanez L, Navallas M, Alba de Caceres I, Martinez E, Borruel SAbstract Clinical evaluation of patients with trauma is challenging, especially in the presence of neurological injuries. Visual loss after trauma is a harmful and usually overlooked consequence that may be avoided with a prompt and accurate intervention. Head CT is commonly performed...
Nasal Mucosal Brush Biopsy for Cat Allergy.: Related ArticlesNasal Mucosal Brush Biopsy for Cat Allergy.Int Forum Allergy Rhinol. 2020 Sep 16;:Authors: Davison W, Alfonso D, An A, Reisacher WRPMID: 32935931 [PubMed - as supplied by publisher]
Sequelae of Major Trauma Patients with Maxillofacial Fractures.: Related ArticlesSequelae of Major Trauma Patients with Maxillofacial Fractures.Ann Otol Rhinol Laryngol. 2020 Sep 16;:3489420958732Authors: Petersen LØ, Ipsen EØ, Felding UA, von Buchwald C, Steinmetz JAbstract OBJECTIVES: Sequelae after maxillofacial fractures are frequent and may affect the patient's quality of life. This study examined sequelae associated with maxillofacial fractures of severely traumatized patients focusing...
Chloroquine Treatment Suppresses Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis.: Related ArticlesChloroquine Treatment Suppresses Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis.Allergy Asthma Immunol Res. 2020 Nov;12(6):994-1011Authors: Choi MR, Xu J, Lee S, Yeon SH, Park SK, Rha KS, Kim YMAbstract PURPOSE: The Toll-like receptor 9 (TLR9) signaling pathway is involved in the pathogenesis of chronic rhinosinusitis (CRS) with nasal...
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.: Related ArticlesEnhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps.Allergy Asthma Immunol Res. 2020 Nov;12(6):980-993Authors: Kim DK, Jo A, Lim HS, Kim JY, Eun KM, Oh J, Kim JK, Cho SH, Kim DWAbstract PURPOSE: Recent studies have revealed the pathogenic role of interleukin (IL)-22 in atopic dermatitis and asthma....
The Persian Version of Utrecht Questionnaire for Evaluation of Aesthetic Rhinoplasty Outcomes: Translation and Validation.: Related ArticlesThe Persian Version of Utrecht Questionnaire for Evaluation of Aesthetic Rhinoplasty Outcomes: Translation and Validation.World J Plast Surg. 2020 May;9(2):141-145Authors: Jahandideh H, Dehghani Firouzabadi F, Dehghani Firouzabadi M, Jfm Lohuis P, Roomiani MAbstract BACKGROUND: There are different questionnaires and approaches to evaluate the outcome...
Trial watch: TLR3 agonists in cancer therapy.: Related ArticlesTrial watch: TLR3 agonists in cancer therapy.Oncoimmunology. 2020 Jun 02;9(1):1771143Authors: Le Naour J, Galluzzi L, Zitvogel L, Kroemer G, Vacchelli EAbstract Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in endosomes. On activation, TLR3 initiates a signal transduction pathway that culminates with the secretion of pro-inflammatory...
MMP2 as an independent prognostic stratifier in oral cavity cancers.: Related ArticlesMMP2 as an independent prognostic stratifier in oral cavity cancers.Oncoimmunology. 2020 May 13;9(1):1754094Authors: Hoffmann C, Vacher S, Sirven P, Lecerf C, Massenet L, Moreira A, Surun A, Schnitzler A, Klijanienko J, Mariani O, Jeannot E, Badois N, Lesnik M, Choussy O, Le Tourneau C, Guillot-Delost M, Kamal M, Bieche I, Soumelis VAbstract Background: Around 25% of oral cavity squamous cell carcinoma...
Tonsillectomy as an effective treatment for arthralgia of SAPHO syndrome.: Related ArticlesTonsillectomy as an effective treatment for arthralgia of SAPHO syndrome.J Surg Case Rep. 2020 Sep;2020(9):rjaa288Authors: Horiguchi S, Fujita T, Kinoshita K, Doi KAbstract Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome has been proposed to describe a clinicoradiological entity manifesting in the joints, skin and bones. We describe a patient with SAPHO syndrome for whom bilateral...
Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers.: Related ArticlesTherapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers.Oncotarget. 2020 Sep 01;11(35):3315-3349Authors: Balhorn R, Balhorn MCAbstract SH7139, the first of a series of selective high affinity ligand (SHAL) oncology drug candidates...
Cyclin D1 overexpression enhances chemosensitivity to TPF chemotherapeutic agents via the caspase-3 pathway in oral cancer.: Related ArticlesCyclin D1 overexpression enhances chemosensitivity to TPF chemotherapeutic agents via the caspase-3 pathway in oral cancer.Oncol Lett. 2020 Nov;20(5):154Authors: Hu YJ, Sun WW, Zhao TC, Liu Y, Zhu DW, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LPAbstract Induction chemotherapy has been previously demonstrated to downgrade locally advanced or aggressive...
Clinical experience of 23 cases of adenoid cystic carcinoma of the external auditory canal.: Related ArticlesClinical experience of 23 cases of adenoid cystic carcinoma of the external auditory canal.Oncol Lett. 2020 Nov;20(5):144Authors: Jiang X, Jia L, Zhang X, Zhong C, Tang F, Chen X, Yuan WAbstract Adenoid cystic carcinoma (ACC) of the external auditory canal (EAC) is a rare tumor. The present study aimed to describe the clinical features and survival of patients with ACC of the EAC....
Keyhole anesthesia-Perioperative management of subglottic stenosis: A case report.: Related ArticlesKeyhole anesthesia-Perioperative management of subglottic stenosis: A case report.Saudi J Anaesth. 2020 Jul-Sep;14(3):403-405Authors: Jafra A, Virk R, Mittal G, Arora K, Arora SAbstract Any narrowing in the airway presents as obstruction and with features of noisy breathing. The presence of subglottic stenosis poses a great challenge to the anesthesiologist. Diagnostic and corrective procedures...
Floppy epiglottis together with extra-laryngeal mass causing an inducible laryngeal obstruction and hypoxemic event in an adult: A case report.: Related ArticlesFloppy epiglottis together with extra-laryngeal mass causing an inducible laryngeal obstruction and hypoxemic event in an adult: A case report.Saudi J Anaesth. 2020 Jul-Sep;14(3):400-402Authors: Keshwani M, Karim HMR, Gourh GAbstract Floppy epiglottis in an adult is rare and often pathological. Airway obstruction caused by floppy...
Influence of head and neck positions on oropharyngeal seal pressure with Baska mask® versus I-gel™; A randomised clinical study.: Related ArticlesInfluence of head and neck positions on oropharyngeal seal pressure with Baska mask® versus I-gel™; A randomised clinical study.Indian J Anaesth. 2020 Aug;64(8):675-680Authors: Sidhu GK, Jindal S, Mahajan R, Bhagat SAbstract Background and Aims: Oropharyngeal seal pressure (OSP) achieved by a supraglottic airway device holds due importance as...
Editor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma.: Related ArticlesEditor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma.Clin Cancer Res. 2020 Sep 15;26(18):5052Authors: Wang D, Müller S, Ruhul Amin ARM, Huang D, Su L, Hu Z, Rahman MA, Nannapaneni S, Koenig L, Chen Z, Tighiouart M, Shin DM, Chen ZGPMID: 32934033 [PubMed - in process]
Keep that flap warm! Use of an infant warmer on free flaps prior to detachment.: Related ArticlesKeep that flap warm! Use of an infant warmer on free flaps prior to detachment.Br J Oral Maxillofac Surg. 2020 Aug 19;:Authors: Chandran A, Chai A, Wotherspoon R, Crank S, Mizen KPMID: 32933787 [PubMed - as supplied by publisher]
Relationships between predischarge and postdischarge infectious complications, length of stay, and unplanned readmissions in the ACS NSQIP database.: Related ArticlesRelationships between predischarge and postdischarge infectious complications, length of stay, and unplanned readmissions in the ACS NSQIP database.Surgery. 2020 Sep 12;:Authors: Aasen DM, Bronsert MR, Rozeboom PD, Colborn KL, Henderson WG, Lambert-Kerzner A, Hammermeister KE, Meguid RAAbstract BACKGROUND: Postoperative complications,...
Horizontal sound localisation and speech perception in Bonebridge-implanted single-sided deafness patients.: Related ArticlesHorizontal sound localisation and speech perception in Bonebridge-implanted single-sided deafness patients.J Laryngol Otol. 2020 Sep 16;:1-8Authors: Zhao C, Yang J, Liu Y, Gao M, Chen P, Zheng J, Zhao SAbstract OBJECTIVE: This study aimed to investigate the benefit of Bonebridge devices in patients with single-sided deafness. METHOD: Five patients with single-sided...
Comparison of Dental Stone Models and Their 3D Printed Acrylic Replicas for the Accuracy and Mechanical Properties.: Related ArticlesComparison of Dental Stone Models and Their 3D Printed Acrylic Replicas for the Accuracy and Mechanical Properties.Materials (Basel). 2020 Sep 13;13(18):Authors: Czajkowska M, Walejewska E, Zadrożny Ł, Wieczorek M, Święszkowski W, Wagner L, Mijiritsky E, Markowski JAbstract This study was conducted to test possibilities of application of 3D printed dental...
Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region.: Related ArticlesAnti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region.Int J Mol Sci. 2020 Sep 13;21(18):Authors: Szepesy J, Miklós G, Farkas J, Kucsera D, Giricz Z, Gáborján A, Polony G, Szirmai Á, Tamás L, Köles L, Varga ZV, Zelles TAbstract...
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.: Related ArticlesThe Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.Diagnostics (Basel). 2020 Sep 11;10(9):Authors: Cui L, Chen H, Zhao XAbstract Metabolic dysregulation has emerged as a crucial determinant of the clinical responses to immunotherapy. The aim of this study was to determine the clinical significance of...
A Modified Ridge Splitting Technique Using Autogenous Bone Blocks-A Case Series.: Related ArticlesA Modified Ridge Splitting Technique Using Autogenous Bone Blocks-A Case Series.Materials (Basel). 2020 Sep 11;13(18):Authors: Pénzes D, Simon F, Mijiritsky E, Németh O, Kivovics MAbstract BACKGROUND: Alveolar atrophy following tooth loss is a common limitation of rehabilitation with dental implant born prostheses. Ridge splitting is a well-documented surgical method to restore the width of...
Risk of Acquired Cholesteatoma and External Auditory Canal Stenosis in Traumatic Brain Injury: A Nationwide Population-Based Cohort Study.: Related ArticlesRisk of Acquired Cholesteatoma and External Auditory Canal Stenosis in Traumatic Brain Injury: A Nationwide Population-Based Cohort Study.Int J Environ Res Public Health. 2020 Sep 11;17(18):Authors: Lin HC, Shih CP, Chen HC, Cheng CA, Huang YS, Lin CS, Chung CH, Huang BR, Lee JC, Shangkuan WC, Chien WC, Chu CMAbstract The aim of study...
Recreation of eyelid mechanics using the sling concept✰.: Related ArticlesRecreation of eyelid mechanics using the sling concept✰.J Plast Reconstr Aesthet Surg. 2020 May;73(5):942-950Authors: Hasmat S, McPherson S, Suaning GJ, Lovell NH, Hubert Low TH, Clark JRAbstract BACKGROUND: Paralytic lagophthalmos causes major functional, aesthetic and psychological problems in patients with facial paralysis. The Bionic Lid Implant for Natural Closure (BLINC) project aims to restore eyelid function...
Panel 1: Biotechnology, biomedical engineering and new models of otitis media.: Related ArticlesPanel 1: Biotechnology, biomedical engineering and new models of otitis media.Int J Pediatr Otorhinolaryngol. 2020 Mar;130 Suppl 1:109833Authors: Gisselsson-Solén M, Tähtinen PA, Ryan AF, Mulay A, Kariya S, Schilder AGM, Valdez TA, Brown S, Nolan RM, Hermansson A, van Ingen G, Marom TAbstract OBJECTIVE: To summarize recently published key articles on the topics of biomedical engineering, biotechnology...
Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing.: Related ArticlesGene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing.Theranostics. 2019;9(24):7184-7199Authors: Kim MA, Kim SH, Ryu N, Ma JH, Kim YR, Jung J, Hsu CJ, Choi JY, Lee KY, Wangemann P, Bok J, Kim UKAbstract Rationale: Mutations of SLC26A4 that abrogate pendrin, expressed...
Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players.: Related ArticlesPremenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players.Neuroimmunomodulation. 2019;26(1):1-6Authors: Foster R, Vaisberg M, Bachi ALL, Dos Santos JMB, de Paula Vieira R, Luna-Junior LA, Araújo MP, Parmigiano TR, Borges F, Di-Bella ZIKJAbstract OBJECTIVE: To evaluate the relationship between the inflammatory profile and mood states in the different phases of the menstrual...
Evidence of transfer of miRNAs from the diet to the blood still inconclusive: MicroRNAs (miRNAs) are short, non-coding, single-strand RNA molecules that act as regulators of gene expression in plants and animals. In 2012, the first evidence was found that plant miRNAs could enter the bloodstream through the digestive tract. Since then, there has been an ongoing discussion about whether miRNAs from the diet are transferred to blood, accumulate in tissues, and regulate gene expression. Different research...
A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps: Publication date: Available online 16 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Tim Delemarre, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Hans Nauwynck, Claus Bachert, Elien Gevaert
White Noise Background Improves Tone Discrimination by Suppressing Cortical Tuning Curves.: Related ArticlesWhite Noise Background Improves Tone Discrimination by Suppressing Cortical Tuning Curves.Cell Rep. 2019 Nov 12;29(7):2041-2053.e4Authors: Christensen RK, Lindén H, Nakamura M, Barkat TRAbstract The brain faces the difficult task of maintaining a stable representation of key features of the outside world in noisy sensory surroundings. How does the sensory representation change with...
What is the relapse after Le Fort I maxillary advancement in cleft lip and palate patients? A systematic review: AbstractLe Fort I osteotomy is the most common procedure for maxillary advancement in cleft patients, and a significant relapse is expected in the postoperative period. This study purpose is to evaluate the maxillary relapse and associated factors in cleft lip and palate (CLP) patients submitted to standard Le Fort I advancement. This systematic review sought studies in PubMed, SCOPUS,...
 Bufalin attenuates triple-negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4.Related Articles Bufalin attenuates triple-negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4. Oncol Lett. 2020 Nov;20(5):171 Authors: Chen F, Zhu L, Hu J, Jiang S, Liu H, Zheng J, Wang J, Wang F, Li Z Abstract Triple-negative breast cancer (TNBC) has the poorest prognosis among all types of breast cancer and there is yet no effective therapy. Chemotherapy is the traditional...
Amentoflavone triggers cell cycle G2/M arrest by interfering with microtubule dynamics and inducing DNA damage in SKOV3 cells.: Related ArticlesAmentoflavone triggers cell cycle G2/M arrest by interfering with microtubule dynamics and inducing DNA damage in SKOV3 cells.Oncol Lett. 2020 Nov;20(5):168Authors: Zhang J, Li A, Sun H, Xiong X, Qin S, Wang P, Dai L, Zhang Z, Li X, Liu ZAbstract Ovarian cancer is the seventh most common cancer and the second most common cause of cancer-associated...
c-myc regulates the sensitivity of breast cancer cells to palbociclib via c-myc/miR-29b-3p/CDK6 axis.: Related Articlesc-myc regulates the sensitivity of breast cancer cells to palbociclib via c-myc/miR-29b-3p/CDK6 axis.Cell Death Dis. 2020 Sep 15;11(9):760Authors: Ji W, Zhang W, Wang X, Shi Y, Yang F, Xie H, Zhou W, Wang S, Guan XAbstract Palbociclib, a CDK4/6 inhibitor, has been granted accelerated approval by US FDA for hormone receptor-positive HER2-negative metastatic breast cancer....
Overexpression of anillin is related to poor prognosis in patients with hepatocellular carcinoma.: Related ArticlesOverexpression of anillin is related to poor prognosis in patients with hepatocellular carcinoma.Hepatobiliary Pancreat Dis Int. 2020 Aug 31;:Authors: Zhang LH, Wang D, Li Z, Wang G, Chen DB, Cheng Q, Hu SH, Zhu JYAbstract BACKGROUND: Anillin (ANLN) is required for tumor growth. It has been proven that knockdown of ANLN effectively reduces the occurrence of hepatocellular carcinoma...
CDK4/6 inhibitors: a novel strategy for tumor radiosensitization.: Related ArticlesCDK4/6 inhibitors: a novel strategy for tumor radiosensitization.J Exp Clin Cancer Res. 2020 Sep 15;39(1):188Authors: Yang Y, Luo J, Chen X, Yang Z, Mei X, Ma J, Zhang Z, Guo X, Yu XAbstract Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics...
A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer.: Related ArticlesA Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer.Biology (Basel). 2020 Sep 11;9(9):Authors: Xiong Y, Zhang Y, Xiong S, Williams-Villalobo AEAbstract p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a broad range of genes to modulate a series of cellular events, including DNA damage repair, cell cycle arrest,...
Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.: Related ArticlesDisease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Nucleic Acids Res. 2020 07 27;48(13):7265-7278Authors: Falquet B, Ölmezer G, Enkner F, Klein D, Challa K, Appanah R, Gasser SM, Rass UAbstract DNA2 is an essential nuclease-helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication...
Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer.: Related ArticlesOrally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer.Theranostics. 2019;9(24):7458-7473Authors: Han W, Xie B, Li Y, Shi L, Wan J, Chen X, Wang HAbstract Purpose: Colitis-associated colorectal cancer (CAC) poses substantial challenges for effective treatment. Currently, there is a considerable need for the development...
Silencing lncRNA HOTAIR declines synovial inflammation and synoviocyte proliferation and promotes synoviocyte apoptosis in osteoarthritis rats by inhibiting Wnt/β-catenin signaling pathway.: Related ArticlesSilencing lncRNA HOTAIR declines synovial inflammation and synoviocyte proliferation and promotes synoviocyte apoptosis in osteoarthritis rats by inhibiting Wnt/β-catenin signaling pathway.Cell Cycle. 2019 Nov;18(22):3189-3205Authors: Mao T, He C, Wu H, Yang B, Li XAbstract Osteoarthritis...
Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.: Related ArticlesProhibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.JCI Insight. 2019 04 18;5:Authors: MacArthur IC, Bei Y, Garcia HD, Ortiz MV, Toedling J, Klironomos F, Rolff J, Eggert A, Schulte JH, Kentsis A, Henssen AGAbstract Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to...
Gold-sputtered microelectrodes with built-in gold reference and counter electrodes for electrochemical DNA detection: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01387K, PaperSaranya Thiruvottriyur Shanmugam, Stanislav Trashin, Karolien De WaelGold-sputtered microelectrodes with built-in gold reference and counter electrodes represent a promising platform for the development of disposable DNA sensors. Pretreating gold electrode surfaces and immobilization of DNA thereon is...The content of...
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity: Angkana T. Huang, Bernardo Garcia-Carreras, Matt D. T. Hitchings, Bingyi Yang, Leah C. Katzelnick, Susan M. Rattigan, Brooke A. Borgert, Carlos A. Moreno, Benjamin D. Solomon, Luke Trimmer-Smith, Veronique Etienne, Isabel Rodriguez-Barraquer, Justin Lessler, Henrik Salje, Donald S. Burke, Amy Wesolowski & Derek A. T. Cummings Nature Communications volume 11, Article...
Statistical Profiling of Oral Cancer and the Prediction of Outcome: AbstractBackgroundThe global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of 'high‐risk' patients and appropriately target combination cancer therapies.MethodsA retrospective review of 467 OSCC patients treated over a 19‐year period facilitated detailed clinico‐pathological...
No clear survival benefit of azacitidine for lower‐risk myelodysplastic syndromes: a retrospective study of Nagasaki: SummaryThe efficacy of azacitidine (AZA) on survival of lower risk (LR) ‐ myelodysplastic syndromes (MDS) is controversial. To address this issue, we retrospectively evaluated the long‐term survival benefit of AZA for patients with LR‐MDS defined by International Prognostic Scoring System (IPSS). Using data from 489 patients with LR‐MDS in Nagasaki, hematologic responses according...
Targeting RNA G‐quadruplex in SARS‐CoV‐2: A Promising Therapeutic Target for COVID‐19?: COVID‐19 pandemic caused by SARS‐CoV‐2 has become a global threat. Understanding the underlying mechanisms and developing innovative treatments are extremely urgent. G‐quadruplexes (G4s) are important non‐canonical nucleic acids structures with distinct biofunctions. Here, we studied four putative G4‐forming sequences (PQSs) in SARS‐CoV‐2 genome. One of them (namely RG‐1), which locates in the coding sequence...
 Two-Year, Randomized, Controlled Trial of Belimumab in Lupus NephritisSystemic lupus erythematosus (SLE), a chronic autoimmune disease characterized by loss of immune tolerance, leads to multisystem inflammation and organ injury. Lupus nephritis, which occurs in 25 to 60% of patients with SLE, is the most common severe manifestation of SLE and a major cause of…The New England Journal of Medicine: Search Results in Allergy\ImmunologyThu Sep 17, 2020 03:00Targeting CD38 with Daratumumab in Refractory...
Comparable behaviour of ring and little fingers due to an artificial reduction in thumb contribution to hold objects: Background The human hand plays a crucial role in accomplishing activities of daily living. The contribution of each finger in the human hand is remarkably unique in establishing object stabilization. According to the mechanical advantage hypothesis, the little finger tends to exert a greater normal force than the ring finger during a supination moment production task...
Cocoa colonic phenolic metabolites are related to HDL-cholesterol raising effects and methylxanthine metabolites and insoluble dietary fibre to anti-inflammatory and hypoglycemic effects in humans: Background In many cocoa intervention studies, health outcomes are related to cocoa components without taking into account the bioavailability of the main bioactive components: phenolic compounds and methylxanthines. Methods The present work associates the results of bioavailability and randomised...
Large left paraduodenal hernia with intestinal ischemia: a case report and literature review: Journal of International Medical Research, Volume 48, Issue 9, September 2020. A left paraduodenal hernia is a rare type of internal hernia but the most common type of peritoneal recess hernia. Preoperative diagnosis of a left paraduodenal hernia is difficult because of its nonspecific clinical manifestations, and it is often confused with other causes of acute abdomen. Diagnosis is therefore often delayed,...
Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study investigated the inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats.MethodsForty-five male Wistar rats were randomly divided into three groups of 15 rats each. Fifty grams of force was used to establish an orthodontic tooth movement model. Baicalin (40 mg/kg) was...
Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo study the characteristics of the intestinal flora in patients with diabetic peripheral neuropathy (DPN) and analyze the association between the intestinal flora and clinical indicators.MethodsWe classified 80 subjects into three groups: patients with DPN (n = 45), patients type 2 diabetes without...
Continuous versus intermittent bolus milk feeding in preterm infants: a meta-analysis: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesTo analyze the evidence comparing the benefits and risks of continuous versus intermittent milk feeding in low birth weight (LBW) infants.MethodsThree electronic databases were searched and screened to identify randomized controlled trials of continuous and intermittent milk feeding of LBW infants up to October 2016.ResultsEight...
Reproducibility and Interobserver Agreement of Different Thyroid Imaging and Reporting Data Systems (TIRADS): Introduction: A number of classification systems (TIRADS) have been developed to estimate the likelihood of malignancy in thyroid nodules, but their reproducibility is yet to be assessed. We evaluated the interobserver variability and diagnostic performance of the TIRADS in Kwak's modification (Kw-TIRADS) and European TIRADS (EU-TIRADS). Methods: Two independent specialists, blinded concerning...
Intensity-modulated radiation therapy versus three-dimensional conformal radiotherapy in head and neck squamous cell carcinoma: long-term and mature outcomes of a prospective randomized trial: Tejpal Gupta, Shwetabh Sinha, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Naveen Mummudi, Monali Swain, Reena Phurailatpam, Kumar Prabhash & Jai Prakash Agarwal Radiation Oncology volume 15, Article number: 218 (2020) Cite this article10 AccessesMetricsdetailsAbstractPurposeTo compare long-term disease-related...
Impact of cigarette smoke on physical‐chemical and molecular proprieties of human skin in an ex vivo model: AbstractBackgroundThis is a study about the skin aging exposome, focusing on the effect of cigarette smoke. Human living skin explants (HSE) were exposed to cigarette smoke (CS) of two cigarettes for 2 hours using a custom‐made exposure chamber, the Pollubox®. Effects on the surface physico‐chemistry and molecular properties of the skin were analyzed and reported for the first time.Basic ProceduresTo...
Serum Anti‐LRPAP1 is a Common Biomarker for Digestive Organ Cancers and Atherosclerotic Diseases: AbstractSome cancers are related to atherosclerotic diseases, therefore these two types of disease may share some antibody biomarkers in common. To investigate this, a first screening was performed of sera from patients with esophageal squamous cell carcinoma (ESCC) or acute ischemic stroke (AIS) for serological identification of antigens using recombinant cDNA expression cloning (SEREX). The amplified...
Vesp v 5 and glycosylated Vesp v 1 are relevant allergens in Vespa velutina nigrithorax anaphylaxis: AbstractVespa velutina nigrithorax (VVN), commonly known as "the yellow‐legged Asian wasp", is one of the 12 colour variants of Vespa velutina (Lepeletier 1836) [1]. Despite being originally from Asia, it has rapidly spread across France, reaching the Basque Country in the north of Spain and Galicia in the northwest of Spain in 2014 [as revised in 2]. The presence of VVN in Great Britain was first...

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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