Antibodies, Vol. 8, Pages 25: Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro Antibodies doi: 10.3390/antib8010025 Authors: Hongqian Wang Yanping Wang Zuoxiang Xiao Wei Li Dimiter S. Dimitrov Weizao Chen The FDA approval of two anti-HER2 monoclonal antibodies, trastuzumab and pertuzumab, and an antibody-drug conjugate, trastuzumab emtansine, has transformed clinical practice for HER2-positive...
Mon Mar 18, 2019 02:00
Antibodies, Vol. 8, Pages 24: IgG Charge: Practical and Biological Implications Antibodies doi: 10.3390/antib8010024 Authors: Danlin Yang Rachel Kroe-Barrett Sanjaya Singh Thomas Laue Practically, IgG charge can contribute significantly to thermodynamic nonideality, and hence to solubility and viscosity. Biologically, IgG charge isomers exhibit differences in clearance and potency. It has been known since the 1930s that all immunoglobulins carry a weak negative charge in physiological...
Thu Mar 14, 2019 02:00
Antibodies, Vol. 8, Pages 23: Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays Antibodies doi: 10.3390/antib8010023 Authors: Marina Cretich Alessandro Gori Ilda D'Annessa Marcella Chiari Giorgio Colombo Peptides and peptidomimetics have attracted revived interest regarding their applications in chemical biology over the last few years. Their chemical versatility, synthetic accessibility and the ease of storage and management compared to full proteins...
Tue Mar 12, 2019 02:00
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