Marwa A Masoud, Amr S Kotb, Ola M Abd El-Raouf, Ebtehal M FikryEgyptian Pharmaceutical Journal 2020 19(1):55-61Backgroundand objective Apigenin (API), as flavonoid, is found in chamomile tea, parsley, celery, onions, lemon balm, and oranges. Therefore, in the present study, we investigated the neuroprotective role of API against oxidative stress, neuroinflammation, and neurotransmitter abnormality induced by cumulative dose of paracetamol (PA) in a rat model of protein malnutrition. Materials and...
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Chandana Kamili, Shivaram Prasad, Battula Harsha Vardhan, Kompelli Koushik, Nadigittu Akshita, Sanjana Yadav, Sharadha Radhakrishnan, Konde Abbulu, Venu Kola, Prasenjit MondalEgyptian Pharmaceutical Journal 2020 19(1):1-6Aim To evaluate the prevalence of vitamin D deficiency in pediatric epileptic patients and to assess if there is any correlation between vitamin D level and disease severity in epileptic patients. Objective To estimate vitamin D deficiency and insufficiency as percentage of enrolled...
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Shaymaa A Ismail, Amira A HassanEgyptian Pharmaceutical Journal 2020 19(1):7-17Background The enzymatic hydrolysis of lignocelluloses into fermentable sugars is the key step in biorefining, and cellulases are the key enzymes. The low titer of cellulase production and their high cost remain the most significant barriers to their industrial applications. The aim of this study was the economic production of cellulase by an Egyptian fungal isolate under solid-state fermentation by using rice straw as...
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Waill A Elkhateeb, Ghoson M Daba, Asmaa N El-Dein, Donia H Sheir, Walid Fayad, Mohamed N Shaheen, ELmahdy M Elmahdy, Ting-Chi WenEgyptian Pharmaceutical Journal 2020 19(1):67-73Background and objective Medicinal mushrooms, as well as lichens are potential sources of bioactive compounds against many lethal diseases. Therefore, in-vitro evaluations of the biological activities of the 80% methanolic extracts of two Japanese originated samples, namely, the mushroom Ganoderma applanatum, and the lichen...
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Rokia A El-Banna, Safenaz Y El Sherity, Maya G AlyEgyptian Pharmaceutical Journal 2020 19(1):18-24Background Childhood asthma is markedly increasing in developing countries. The first line of management according to national asthma guidelines is inhaled corticosteroids. Accurate body composition analysis, with persistent asthma control by steroid therapy, is essential in childhood, as the potential effects of the long-term and short-term treatments are still a matter of concern. Aim To assess the...
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Shaymaa M Bata, Khaled A Shams, Ali Kh Khalil, Rasmia A Hassan, Ibrahim A Saleh, Ahmed R Hamed, Nahla S Abdel-Azim, Faiza M HammoudaEgyptian Pharmaceutical Journal 2020 19(1):47-54Background and objectives Quinoa (Chenopodium quinoa Willd) is a plant species that belongs to Chenopodiaceae family. It has a high nutritional value as it is rich in proteins, lipids, and fiber, and has an extraordinary balance of essential amino acids, vitamins, and minerals, in addition to a high number of health-beneficial...
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Wafaa K Hegazy, Mohamed S Abdel-Salam, Maysa E MoharamEgyptian Pharmaceutical Journal 2020 19(1):25-28Background and objectives The aim of this paper was to focus on improving production level of l-asparaginase by developing recombinant strains. Materials and methods Asp gene was cloned into the shuttle vector pNW33N, and the recombinant plasmid was used to transform Bacillus subtilis protoplast. Asp gene was expressed into both Escherichia coli and B. subtilis. Enzyme activity of the recombinant...
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Muhammad T Umar, Shaibu O Bello, Aminu Chika, Yakubu AbdulmuminiEgyptian Pharmaceutical Journal 2020 19(1):62-66Background and objective High expression and activity of cytochrome P450 2E1 have been linked to non-alcoholic fatty liver disease; increased susceptibility to the gastric, nasopharyngeal, colorectal, urinary bladder and esophageal malignancies; and acetaminophen-induced hepatotoxicity. It plays key roles in activating procarcinogens to carcinogens, metabolism of xenobiotics, and hosts...
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Om K.H Khattab, Siham A Ismail, Nivien A Abosereh, Amany A Abo-Elnasr, Shaimaa A Nour, Amal M HashemEgyptian Pharmaceutical Journal 2020 19(1):29-46Background and objective β-Mannanase has potential industrial applications in pharmaceutical field, bioethanol production, coffee extraction, food and feed technology, etc. So finding a new and promising enzyme source is a very important issue. The aim of this study was to improve the biosynthesis of β-mannanase by different techniques, such as mutation...
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Shiva Roshankhah, Amir Abdolmaleki, Arash Ziapoor, Mohammad Reza SalahshoorEgyptian Pharmaceutical Journal 2020 19(1):74-80Background and objectives Diabetes mellitus is one of the most prevalent metabolic disorders worldwide. Cardiac angiogenesis disruption occurs in diabetes. Petroselinum crispum has antioxidant properties leading to its therapeutic attributes. Materials and methods Sixty-four male Wistar rats were randomly sorted into eight groups: control, extract groups (50, 100, and 150 mg/kg...
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