IJERPH, Vol. 14, Pages 1456: Urinary Phthalate Concentrations in Mothers and Their Children in Ireland: Results of the DEMOCOPHES Human Biomonitoring Study

IJERPH, Vol. 14, Pages 1456: Urinary Phthalate Concentrations in Mothers and Their Children in Ireland: Results of the DEMOCOPHES Human Biomonitoring Study

International Journal of Environmental Research and Public Health doi: 10.3390/ijerph14121456

Authors: Elizabeth Cullen David Evans Chris Griffin Padraig Burke Rory Mannion Damien Burns Andrew Flanagan Ann Kellegher Greet Schoeters Eva Govarts Pierre Biot Ludwine Casteleyn Argelia Castaño Marike Kolossa-Gehring Marta Esteban Gerda Schwedler Holger Koch Jürgen Angerer Lisbeth Knudsen Reinhard Joas Anke Joas Birgit Dumez Ovnair Sepai Karen Exley Dominique Aerts

Background: Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the 'Demonstration of a study to Co-ordinate and Perform Human Biomonitoring on a European Scale' (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents from families with lower educational attainment and in those exposed to such items as polyvinyl chloride (PVC), fast food and personal care products (PCP). Conclusions: The study demonstrates that human biomonitoring for assessing exposure to phthalates can be undertaken in Ireland and that the exposure of the population is widespread. Further work will be necessary before the consequences of this exposure are understood.

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