Cancers, Vol. 11, Pages 915: Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical ApplicationCancers doi: 10.3390/cancers11070915Authors: Mulder Wahlin Österborg PalmaIn lymphomas of B-cell origin, cancer cells orchestrate an inflammatory microenvironment of immune and stromal cells that sustain the tumor cell survival and growth, known as a tumor microenvironment (TME). The features of the TME differ between the different lymphoma types, ranging from extremely...
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Combined Confocal Microscope and Brandaris 128 Ultra-High-Speed Camera20mvia Ultrasound in Medicine & BiologyPublication date: Available online 29 June 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Inés Beekers, Kirby R. Lattwein, Joop J.P. Kouijzer, Simone A.G. Langeveld, Merel Vegter, Robert Beurskens, Frits Mastik, Rogier Verduyn Lunel, Emma Verver, Antonius F.W. van der Steen, Nico de Jong, Klazina KooimanAbstractControlling microbubble-mediated drug delivery requires the underlying...
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Real-World Performance of Computer-Aided Diagnosis System for Thyroid Nodules Using Ultrasonography17mvia Ultrasound in Medicine & BiologyPublication date: Available online 29 June 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Hye Lin Kim, Eun Ju Ha, Miran HanAbstractThis study evaluated the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system (S-Detect 1 and S-Detect 2 for thyroid) for detecting thyroid cancers. Among 218 thyroid nodules in 106...
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Journal of Neuroscience Methods,A visual encoding model based on deep neural networks and transfer learning for brain activity measured by functional magnetic resonance imagingPublication date: Available online 27 June 2019Source: Journal of Neuroscience MethodsAuthor(s): Chi Zhang, Kai Qiao, Linyuan Wang, Li Tong, Guoen Hu, Ru-Yuan Zhang, Bin YanAbstractBackgroundBuilding visual encoding models to accurately predict visual responses is a central challenge for current vision-based brain-machine...
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Revue des Maladies Respiratoires,Efficacité mais allergie au mepolizumab (Nucala)Publication date: May 2019Source: Revue des Maladies Respiratoires, Volume 36, Issue 5Author(s): C. Giordanengo, C. LineauNous rapportons le cas d'une patiente âgée de 70 ans suivie pour un asthme allergique sévère au stade d'insuffisance respiratoire chronique obstructive cortico dépendant. Mme R a été traitée pendant plusieurs années par omalizumab avec une bonne tolérance cutanée. Le traitement avait permis d'éviter...
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World Neurosurgery,8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature ReviewPublication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Mengchen Yin, Junming Ma, Jie Ye, Hua Xu, Wen MoBackgroundPrimary melanocytic neoplasms in the central nervous system are rare lesions arising from leptomeningeal melanocytes. These lesions produce neural deficits that resemble those of a meningioma or a schwannoma radiologically.Case DescriptionA...
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Cancer Epidemiology (open access),The burden of squamous cell carcinoma of the conjunctiva in AfricaPublication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Lucia Hämmerl, Jacques Ferlay, Margaret Borok, Carla Carrilho, Donald Maxwell ParkinAbstractSquamous cell carcinoma of the conjunctiva (SCCC) is a relatively common cancer in Africa, although its precise incidence and geographic distribution have not been previously systematically studied.MethodsUsing the methods employed...
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Ultrasound in Medicine & Biology,Real-World Performance of Computer-Aided Diagnosis System for Thyroid Nodules Using UltrasonographyPublication date: Available online 29 June 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Hye Lin Kim, Eun Ju Ha, Miran HanAbstractThis study evaluated the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system (S-Detect 1 and S-Detect 2 for thyroid) for detecting thyroid cancers. Among 218 thyroid nodules in 106 patients,...
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Identification of PKCα-dependent phosphoproteins in mouse retina19hvia ScienceDirect Publication: Journal of ProteomicsPublication date: Available online 28 June 2019Source: Journal of ProteomicsAuthor(s): Colin M. Wakeham, Phillip A. Wilmarth, Jennifer M. Cunliffe, John E. Klimek, Gaoying Ren, Larry L. David, Catherine W. MorgansAbstractAdjusting to a wide range of light intensities is an essential feature of retinal rod bipolar cell (RBC) function. While persuasive evidence suggests this modulation...
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Preclinical Combination Studies of an FGFR2 Targeted Thorium Conjugate and the ATR Inhibitor BAY 189534419hvia Radiation Molecular Biology.Publication date: Available online 27 June 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Katrine Wickstroem, Urs B. Hagemann, Alexander Kristian, Christine Ellingsen, Anette Sommer, Heidrun Ellinger-Ziegelbauer, Uta Wirnitzer, Else-Marie Hagelin, Aasmund Larsen, Roger Smeets, Roger M. Bjerke, Jenny Karlsson, Olav B. Ryan, Antje...
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BK virus histopathologic disease severity does not predict allograft outcome in renal transplant recipients19hvia Annals of Diagnostic PathologyPublication date: Available online 27 June 2019Source: Annals of Diagnostic PathologyAuthor(s): M. Lee Sanders, Melissa Swee, Mony Fraer, Sarat Kuppachi, Patrick Ten Eyck, Prerna RastogiAbstractAimsBK polyomavirus nephropathy (BKPyVN) is an important cause of allograft failure after renal transplantation. Despite early screening for the virus, allograft loss...
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Trial by phylogenetics - Evaluating the Multi-Species Coalescent for phylogenetic inference on taxa with high levels of paralogy (Gonyaulacales, Dinophyceae) [NEW RESULTS]25mby Kretzschmar, A. L. via bioRxiv Subject Collection: Evolutionary BiologyFrom publicly available next-gen sequencing datasets of non-model organisms, such as marine protists, arise opportunities to explore their evolutionary relationships. In this study we explored the effects that dataset and model selection have on the phylogenetic...
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Prognostic and predictive markers in liver limited stage IV colorectal cancer19hvia European Journal of Surgical Oncology (EJSO)Publication date: Available online 27 June 2019Source: European Journal of Surgical OncologyAuthor(s): Adeeb H. Rehman, Robert P. Jones, Graeme PostonAbstractColorectal cancer is the third most commonly diagnosed cancer among both men and women. Personalised treatment options remain complex, although there is broad agreement over which patients with colorectal liver metastases...
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Archives of Physical Medicine and Rehabilitation,Foot Function Index: a promising questionnaire for patients with Charcot-Marie-Tooth disease type 1APublication date: Available online 28 June 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Lucie Bihel, Vivien Reynaud, Pascal Givron, Pierre Clavelou, Catherine Cornut-Chauvinc, Bruno Pereira, Eric Thomas, Frederic Taithe, Emmanuel CoudeyreAbstractObjectiveTo evaluate in a preliminary methodological study, the Foot Function Index...
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Foot Function Index: a promising questionnaire for patients with Charcot-Marie-Tooth disease type 1A19hvia Archives of Physical Medicine and RehabilitationPublication date: Available online 28 June 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Lucie Bihel, Vivien Reynaud, Pascal Givron, Pierre Clavelou, Catherine Cornut-Chauvinc, Bruno Pereira, Eric Thomas, Frederic Taithe, Emmanuel CoudeyreAbstractObjectiveTo evaluate in a preliminary methodological study, the Foot Function...
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Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling18hvia Journal of the Association for Research in OtolaryngologyAbstractCholesteatoma starts as a retraction of the tympanic membrane and expands into the middle ear, eroding the surrounding bone and causing hearing loss and other serious complications such as brain abscess and meningitis. Currently, the only effective treatment is complete surgical removal, but the recurrence rate is relatively high. In rheumatoid arthritis (RA),...
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International Immunopharmacology,Elevated plasma BDNF levels are correlated with NK cell activation in patients with traumatic spinal cord injuryPublication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Long Xu, Yong Zhang, Renjie Zhang, Huaqing Zhang, Peiwen Song, Tai Ma, Yue Li, Xian Wang, Xin Hou, Qun Li, Jiegou Xu, Xiaoping Gao, Cailiang ShenAbstractBackgroundThe precise role of innate immune responses in the early stage of traumatic spinal cord injury (SCI),...
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Inhibition of HDAC6 attenuates LPS-induced inflammation in macrophages by regulating oxidative stress and suppressing the TLR4-MAPK/NF-κB pathways18hvia Biomedicine & PharmacotherapyPublication date: September 2019Source: Biomedicine & Pharmacotherapy, Volume 117Author(s): Wen-bin Zhang, Fan Yang, Yao Wang, Fang-zhou Jiao, Hai-yue Zhang, Lu-wen Wang, Zuo-jiong GongAbstractBackgroundHistone deacetylase 6 (HDAC6) has been considered as an important regulator in the development of inflammatory...
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Quality of life and decision regret after postoperative radiation therapy to the prostatic bed region with or without elective pelvic nodal radiation therapy18hvia Practical Radiation OncologyPublication date: Available online 27 June 2019Source: Practical Radiation OncologyAuthor(s): Carola Link, Patrick Honeck, Frank Lohr, Christian Bolenz, Joerg Schaefer, Markus Bohrer, Frank Anton Giordano, Frederik Wenz, Daniel BuergyAbstractPurposeTo evaluate patient-reported quality of life (HRQOL) and decision...
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Clinical performance of occlusal onlays made of lithium disilicate ceramic in patients with severe tooth wear up to 11 years18hvia Dental MaterialsPublication date: Available online 28 June 2019Source: Dental MaterialsAuthor(s): D. Edelhoff, J.F. Güth, K. Erdelt, O. Brix, A. LiebermannAbstractObjectivesEvaluation of survival and complication rate of monolithic occlusal onlays made of lithium disilicate ceramic used in patients with severe tooth wear up to 11 years of clinical service.MethodsIn a...
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Allergy and Clinical Immunology,Evaluation of Long-term Course in Children with Eosinophilic Esophagitis Reveals Distinct Histologic Patterns and Clinical CharacteristicsPublication date: Available online 28 June 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Cathleen Collins, Jacob Palmquist, James A. Proudfoot, Alex Qian, Hannah Wangberg, Emad Khosh-Hemmat, Ranjan Dohil, Seema S. AcevesAbstractBackgroundEosinophilic esophagitis (EoE) is a chronic, increasingly prevalent antigen...
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Historical Archaeology,Gendered Landscapes: Women, Materiality, and Historical Memory in Deerfield, MassachusettsAbstract Many historical elements visible on landscapes today, such as structures, vegetation, waterways, and landforms, sometimes give the impression of having survived substantially unchanged since their beginnings centuries ago. Moreover, this aura of "timelessness" is often deliberately encouraged by various means, for multiple and complex reasons. The movement for historic preservation...
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International Journal of Psychophysiology,Stress and recovery in sports: Effects on heart rate variability, cortisol, and subjective experiencePublication date: Available online 27 June 2019Source: International Journal of PsychophysiologyAuthor(s): P. Vacher, E. Filaire, L. Mourot, M. NicolasAbstractThis study aimed to investigate (1) the time-variations and (2) the repeated measures relationship between training load (TL) and psychological and physiological parameters and performance. Data were...
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British Journal of Oral and Maxillofacial Surgery,Cleft and craniofacial surgery training: is it time for a new solution for UK trainees?Publication date: Available online 28 June 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Shofiq IslamBritish Journal of Oral and Maxillofacial Surgery18hQuantification of the inaccuracy of conventional articulator model surgery in Le Fort 1 osteotomy: evaluation of 30 patients controlled by the Orthopilot<sup>®</sup> navigation...
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Primary central nervous system lymphoma: novel precision therapies17hvia Critical Reviews in Oncology/Hematology (open access)Publication date: Available online 27 June 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Patrizia Mondello, Michael Mian, Francesco BertoniAbstractPrimary central nervous system lymphoma (PCNSL) is a rare and aggressive form of diffuse large B-cell lymphoma. The frontline treatment with high-dose methotrexate based immunochemotherapy is not curative for the...
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Medgadget,Protein-Loaded Antimicrobial Hydrogel to Treat, Prevent Bone InfectionsBone infections are quite common following orthopedic surgery or as a result of injury or disease. They can be incredibly difficult to treat, and heavy duty antibiotic regimens coupled with debridement surgery is the current approach. Even after all that, inflammation is a frequent side effect. Now, researchers at Georgia Tech have created a hydrogel material that can be used to treat bone infections and even prevent...
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Plastic and Reconstructive Surgery - Published Ahead-of-Print,Impact of the unremoved peri-implant capsule and subtotal capsulectomy on the nasal length after extracting nasal silicone implantBackground: Little is known regarding nasal deformities after post-rhinoplasty silicone implant extraction, including the contributory factors such as unremoved peri-implant capsule. This study investigated whether the retained capsule causes contracture and short nose deformity after silicone implant removal,...
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Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling16hvia Latest Results for Journal of the Association for Research in OtolaryngologyAbstractCholesteatoma starts as a retraction of the tympanic membrane and expands into the middle ear, eroding the surrounding bone and causing hearing loss and other serious complications such as brain abscess and meningitis. Currently, the only effective treatment is complete surgical removal, but the recurrence rate is relatively high. In rheumatoid...
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Reduced CTL motility and activity in avascular tumor areas16hvia Cancer Immunology, ImmunotherapyAbstractPatchy infiltration of tumors by cytotoxic T cells (CTLs) predicts poorer prognosis for cancer patients. The factors limiting intratumoral CTL dissemination, though, are poorly understood. To study CTL dissemination in tumors, we histologically examined human melanoma samples and used mice to image B16-OVA tumors infiltrated by OT-I CTLs using intravital two-photon microscopy. In patients, most...
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The Association between Epidermal Growth Factor Receptor Single Nucleotide Polymorphisms and Radiochemotherapy Response in Cervical Cancer14hvia Pathology & Oncology ResearchAbstractEmerging data reveal that epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) can act as efficacy indicators for tumor treatment. Here, the association between EGFR R497K (rs11543848) and -216G/T (rs712829) SNPs and radiochemotherapy response in cervical cancer was investigated. EGFR R497K...
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JoVE: Journal of Visualized Experiments,Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic AcidsWe present a method useful for large-scale enzymatic synthesis and purification of specific enantiomers and regioisomers of epoxides of arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) with the use of a bacterial cytochrome P450 enzyme (BM3).JoVE: Journal of Visualized Experiments14hSA-β-Galactosidase-Based Screening Assay...
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Plastic, Reconstructive & Aesthetic Surgery,Preserved Nipple Erectile Function after Free Nipple Areolar Complex TransplantationIt is generally believed that sensory innervation and preservation of nipple erectile function are lost after free nipple areolar complex (NAC) transplantation. We, however, would like to present a case that already reported 'restored' nipple erectile function two weeks after free NAC transplantation following bilateral mastectomy and breast free flap reconstruction...
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Potential improvement of survival statistics for glioblastoma multiforme (WHO IV)11hby jim via Surgical neurology internationalPotential improvement of survival statistics for glioblastoma multiforme (WHO IV)Category:Article Type:Harry S. GoldsmithDepartment of Neurosurgery (Retired), University of California, Davis, Sacramento, California, United States.DOI:10.25259/SNI-185-2019Copyright: © 2019 Surgical Neurology International This is an open-access article distributed under the terms of the Creative...
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Cranial migration of lumboperitoneal shunt: A case report and review of literature12hby jim via Surgical neurology internationalCranial migration of lumboperitoneal shunt: A case report and review of literatureCategory:Article Type:Amr AlBakry, Mahmoud M. Taha, Hassan A. Al MenshawyDepartments of Neurosurgery, Zagazig University, Zagazig, Egypt,Departments of Neurosurgery, AlMokatam Insurance Hospital, Cairo, Egypt.Correspondence Address:Mahmoud M. TahaDepartments of Neurosurgery, AlMokatam Insurance...
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Unstable os odontoideum contributing to cervical myelopathy and obstructive sleep apnea12hby jim via Surgical neurology internationalUnstable os odontoideum contributing to cervical myelopathy and obstructive sleep apneaCategory:Article Type:Abolfazl Rahimizadeh, Zahed Malekmohammadi, Mona Karimi, Ava Rahimizadeh, Naser AsgariPars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.DOI:10.25259/SNI-308-2019Copyright: ©...
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A case of unilateral vertebral artery dissection progressing in a short time period to bilateral vertebral artery dissection11hby jim via Surgical neurology internationalA case of unilateral vertebral artery dissection progressing in a short time period to bilateral vertebral artery dissectionCategory:Article Type:Kiyoshi Tsuji, Akira Watanabe, Nobuhiro Nakagawa, Amami KatoDepartments of Neurosurgery, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, JapanDepartments...
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A case of leptomeningeal metastases of human epidermal growth factor receptor 2-positive breast cancer that responded well to lapatinib plus capecitabine11hby jim via Surgical neurology internationalA case of leptomeningeal metastases of human epidermal growth factor receptor 2-positive breast cancer that responded well to lapatinib plus capecitabineCategory:Article Type:Takayuki Nakao, Takeshi Okuda, Mitsugu Fujita, Amami KatoDepartments of Neurosurgery Kindai University Faculty of Medicine, Osaka-Sayama,...
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Retractorless interhemispheric transtentorial approach for large lesions in the posterior incisural space11hby jim via Surgical neurology internationalRetractorless interhemispheric transtentorial approach for large lesions in the posterior incisural spaceCategory:Article Type:Miguel Angel Lopez-Gonzalez, Andrew Jaeger, Brett Kaplan, Timothy Marc Eastin, Lydia Kore, Vadim Gospodarev, Puja D. Patel, Fransua SharafeddinDepartment of Neurosurgery, Loma Linda University School of Medicine, Loma Linda,Department...
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Catheter fragment retrieved from an arterial branch of the right middle cerebral artery11hby jim via Surgical neurology internationalCatheter fragment retrieved from an arterial branch of the right middle cerebral arteryCategory:Article Type:Javier Goland, Ezequiel Yasuda, Martín Monteverde, Silvia GarbuginoDepartment of Neurosurgery, Hospital de Clínicas, José de San Martín, Ciudad de Buenos Aires.Department of Cardiology, Hospital de Clínicas, José de San Martín, Ciudad de Buenos Aires.Correspondence...
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Oculomotor neuropathy from an unruptured arteriovenous malformation in the frontal operculum: A case report11hby jim via Surgical neurology internationalOculomotor neuropathy from an unruptured arteriovenous malformation in the frontal operculum: A case reportCategory:Article Type:Fadi Al Saiegh, Kevin Hines, Nikolaos Mouchtouris, Thana Theofanis, Pascal Jabbour, Robert Rosenwasser, Stavropoula TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.DOI:10.25259/SNI-260-2019Copyright:...
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Surgical microanatomy of the occipital artery for suboccipital muscle dissection and intracranial artery reconstruction11hby jim via Surgical neurology internationalSurgical microanatomy of the occipital artery for suboccipital muscle dissection and intracranial artery reconstructionCategory:Article Type:Yuto Hatano, Nakao Ota, Kosumo Noda, Yasuaki Okada, Yosuke Suzuki, Shusei Fukuyama, Shuichi Tanada, Atsumu Hashimoto, Tomomasa Kondo, Takanori Miyazaki, Yu Kinoshita, Hiroyasu Kamiyama, Sadahisa...
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Surgical neurology international,Surgical microanatomy of the occipital artery for suboccipital muscle dissection and intracranial artery reconstructionSurgical microanatomy of the occipital artery for suboccipital muscle dissection and intracranial artery reconstruction Category: Article Type: Yuto Hatano, Nakao Ota, Kosumo Noda, Yasuaki Okada, Yosuke Suzuki, Shusei Fukuyama, Shuichi Tanada, Atsumu Hashimoto, Tomomasa Kondo, Takanori Miyazaki, Yu Kinoshita, Hiroyasu Kamiyama, Sadahisa Tokuda, Rokuya...
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Surgical Treatment of Tracheal Lipoma after Multiple Bronchoscopy Interventions and Placements of a Tracheal Stent9hby Zhang, Xiaoming via The Thoracic and Cardiovascular Surgeon ReportsTHORAC CARDIOV SURG Reports 2019; 08: e20-e23DOI: 10.1055/s-0039-1688903Background The majority of adult primary tracheal tumors are malignant; however, as one type of benign tumors, lipoma is extremely uncommon. Case Description We report a case where lipoma was first misdiagnosed as bronchial asthma, followed by...
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Journal of the American Chemical Society: [ASAP] A Transient and Flexible Cation-p Interaction Promotes Hydrolysis of Nucleic Acids in DNA and RNA NucleasesJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b03663Journal of the American Chemical Society: Latest Articles (ACS Publications)8h[ASAP] Invading <italic toggle="yes">Escherichia coli</italic> Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)Journal of the American Chemical SocietyDOI:...
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Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab7hby Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K., Soejima, K. via Molecular Cancer Therapeutics Online First ArticlesEpidermal growth factor receptor (EGFR)-mutated lung cancer is a significant subgroup of non-small cell lung cancer. To inhibit EGFR-mediated signals, multiple EGFR tyrosine...
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The fluorescein angiographic photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: Outcomes of combined therapy4mvia ScienceDirect Publication: Photodiagnosis and Photodynamic TherapyPublication date: Available online 28 June 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Buğra Karasu, Derya Özkan, Gürkan Erdoğan, Özgür ArtunayAbstractIdiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome is a disease characterized by...
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Image quality and semi-quantitative measurements of the Siemens Biograph Vision PET/CT: Initial experiences and comparison with Siemens Biograph mCT PET/CTIn May 2018 the new Biograph Vision PET/CT (Siemens Healthineers, Knoxville, USA) was introduced at the University Medical Center Groningen. This study evaluated the initial experiences with this new PET/CT system in terms of perceived image quality and semi-quantitative analysis in comparison to the Biograph mCT (Siemens Healthineers, Knoxville,...
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The Journal of Nuclear Medicine (JNM)—self-published by the Society of Nuclear Medicine and Molecular Imaging (SNMMI), a nonprofit, international scientific and professional organization—offers readers around the globe clinical investigations, basic science reports, continuing education articles, book reviews, employment opportunities, and updates on rapidly changing issues in practice and research. JNM—the flagship publication of the Society of Nuclear Medicine and Molecular Imaging (SNMMI)—ranked...
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Evolutionary Biology News -- ScienceDaily,What made humans 'the fat primate'?How did humans get to be so much fatter than our closest primate relatives, despite sharing 99% of the same DNA? A new study suggests that part of the answer may have to do with an ancient molecular shift in how DNA is packaged inside fat cells, which curbed our body's ability to turn 'bad' white fat into 'good' brown fat.Evolutionary Biology News -- ScienceDaily7hEmbracing bioinformatics in gene banksScientists have explored,...
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Clinical Cancer Research Online First Articles,Prognostic score and cytogenetic risk classification for chronic lymphocytic leukemia patients: Center for International Blood and Marrow Transplant Research reportPurpose: To develop a prognostic model and cytogenetic risk classification for previously treated patients with chronic lymphocytic leukemia (CLL) undergoing reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT). Experimental Design: We performed a retrospective...
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Evolutionary Biology,Striking differences in virulence, transmission, and sporocyst growth dynamics between two schistosome populations [NEW RESULTS]Background: Parasite traits associated with transmission success, such as the number of infective stages released from the host, are expected to be optimized by natural selection. However, in the trematode parasite Schistosoma mansoni, a key transmission trait - the number of cercariae larvae shed from infected Biomphalaria spp. snails - varies significantly...
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Vitamin K 3 thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells 6hvia Latest Results for Investigational New DrugsSummaryVitamin K3, also known as menadione, is a synthetic lipid-soluble 2-methyl-1,4- naphthoquinone analogs of vitamin K. The vitamin K derivatives exhibit potent cytotoxicity against several cancer cell lines through ROS induction and mitochondrial dysfunction. We investigated vitamin K3-inspired derivatives as potential apoptotic...
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NEJM : Research,Application of High-Sensitivity Troponin in Suspected Myocardial InfarctionChest pain suggestive of myocardial infarction is a leading cause of presentation to the emergency department worldwide. In addition to the electrocardiogram and clinical symptoms, the serial measurement of cardiac troponin is key in ruling out or diagnosing myocardial infarction. With the…NEJM : Research6hEarly Sedation with Dexmedetomidine in Critically Ill PatientsSedation is a component of the care of critically...
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Pigment Cell & Melanoma Research: Loss‐of‐function mutations in the melanocortin‐1‐receptor (Mc1r) cause disruption of dorso‐ventral countershading in teleost fishAbstract The Melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes. Additionally, in mammals MC1R is the main receptor for agouti signaling protein (ASIP), making it the critical receptor for the establishment of...
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Asthma and anaphylaxisPurpose of review Both asthma and anaphylaxis are recognized noncommunicable hypersensitivity conditions, which should be correctly diagnosed and treated/controlled in order to decrease avoidable deaths. Nevertheless, their association is not completely clear. We here propose to review the current and new evidence-based data of asthma and anaphylaxis in the view of the new knowledge in the field that can support the quality practice and empower allergists and health professionals...
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A Prospective Randomized Trial Comparing Topical Intranasal Lidocaine and Levobupivacaine in Patients Undergoing Endoscopic Binostril Transnasal Transsphenoidal Resection of Pituitary Tumors17hby Konay, Arun S.; Williams, Aparna; Chacko, Ari G.; Singh, Georgene via Journal of Neurosurgical Anesthesiology - Published Ahead-of-PrintIntroduction: Local anesthetic intranasal packing is used in transnasal surgery to reduce hemodynamic fluctuations. We hypothesized that the long acting local anesthetic...
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Population Genome Sequencing of the Scab Fungal Species Venturia inaequalis, Venturia pirina, Venturia aucupariae and Venturia asperata6hby Le Cam, B., Sargent, D., Gouzy, J., Amselem, J., Bellanger, M.-N., Bouchez, O., Brown, S., Caffier, V., De Gracia Coquerel, M., Debuchy, R., Duvaux, L., Payen, T., Sannier, M., Shiller, J., Collemare, J., Lemaire, C. via G3: .Genes, Genomes, Genetics Mission - Online First ArticlesThe Venturia genus comprises fungal species that are pathogens on Rosaceae host...
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Diagnosis of cyclic Cushing's disease manifests as early morning hyperglycemia in a patient with previously well-controlled type 1 diabetes16hvia Journal of Pediatric Endocrinology and Metabolism.Translate articleJournal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of printAbstractBackgroundCyclic Cushing's disease (CCD) is reported to occur in approximately 15% of patients with Cushing's disease (CD). CCD is a rare phenomenon in children.Case presentationA Portuguese female...
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Multisensory Perceptual Awareness: Categorical or Graded?18hvia CortexPublication date: Available online 27 June 2019Source: CortexAuthor(s): Jean-Paul Noel, Nathan Faivre, Elisa Magosso, Olaf Blanke, David Alais, Mark WallaceAbstractNeural evidence suggests that mechanisms associated with conscious access (i.e., the ability to report on a conscious state) are "all-or-none". Upon crossing some threshold, neural signals are globally broadcast throughout the brain and allow conscious reports. However,...
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Extracting biomolecule collision cross sections from FT-ICR mass spectral line shape18hvia ScienceDirect Publication: TalantaPublication date: Available online 28 June 2019Source: TalantaAuthor(s): Yang Tang, Dayu Li, Dong Cao, Wei XuAbstractTo extend the ion structure analysis capability of Fourier transform mass spectrometry (FT-MS), both time-domain and frequency-domain methods have been developed to extract ion collision cross sections (CCS) from high resolution mass spectra in Fourier transform...
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How to Reduce False Positive Recall Rates in Screening Mammography?17hvia Academic RadiologyPublication date: Available online 27 June 2019Source: Academic RadiologyAuthor(s): Almir G.V. Bitencourt, Carolina Rossi Saccarelli, Elizabeth A. Morris
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Orthogonal tensor dictionary learning for accelerated dynamic MRI19hvia Latest Results for MedicalAbstractA direct application of the compressed sensing (CS) theory to dynamic magnetic resonance imaging (MRI) reconstruction needs vectorization or matricization of the dynamic MRI data, which is composed of a stack of 2D images and can be naturally regarded as a tensor. This 1D/2D model may destroy the inherent spatial structure property of the data. An alternative way to exploit the multidimensional...
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Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms13hvia Latest Results for PsychopharmacologyAbstractBackgroundAversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover,...
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Vitamin K 3 thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells6hvia Latest Results for Investigational New DrugsSummaryVitamin K3, also known as menadione, is a synthetic lipid-soluble 2-methyl-1,4- naphthoquinone analogs of vitamin K. The vitamin K derivatives exhibit potent cytotoxicity against several cancer cell lines through ROS induction and mitochondrial dysfunction. We investigated vitamin K3-inspired derivatives as potential apoptotic...
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Alec John "Jack" Kelso15hby Natalie Konopinski via Anthropology-NewsJack Kelso. University of ColoradoMay 25, 2019Alec John "Jack" Kelso died at Frasier Meadows retirement community on May 25, 2019. He was preceded in death by his wife, Mary Kelso. He is survived by his two children, Colette and Bill, three grandchildren, Lara, Rye, and AJ, and by one great-grandchild, June Dylan Wallace. Kelso had a distinguished career as a scholar, teacher, mentor, and administrator.Kelso received his PhD in anthropology...
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Characteristic asymmetric limbic and anterior temporal atrophy in demented patients with pathologically confirmed argyrophilic grain disease11mvia NeuroradiologyAbstractPurposeThe purpose of this study is to clarify the characteristic structural magnetic resonance imaging (MRI) findings in demented patients with pathologically confirmed argyrophilic grain disease (AGD).MethodsNine pathologically confirmed AGD patients with cerebral three-dimensional T1-weighted MRI were evaluated in this study. In...
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Clinical and translational oncology,Efficacy and safety of immune checkpoint inhibitor immunotherapy in elderly cancer patientsAbstract Purpose There is limited evidence on the efficacy and safety of anti-programmed cell death protein 1 (PD-1)-/anti-programmed death-ligand 1 (PD-L1)-based immunotherapy in the elderly, particularly those aged over 75 years. Methods/patients The clinical response and toxicity profile of anti-PD-1-/anti-PD-L1-based immunotherapy in patients aged over...Clinical and...
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Autonomic and Psychologic Risk Factors for Development of Tinnitus in Patients with Chronic Temporomandibular Disorders.Related ArticlesAutonomic and Psychologic Risk Factors for Development of Tinnitus in Patients with Chronic Temporomandibular Disorders. J Oral Facial Pain Headache. 2019 Jun 24;: Authors: Kang JH, Song SI Abstract AIMS: To investigate the roles of autonomic regulation and psychologic condition in the development of tinnitus in patients with chronic temporomandibular disorders (TMD)....
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A Phenomenologic Study About the Dietary Habits and Digestive Complications for People Living with Temporomandibular Joint Disorder.Related ArticlesA Phenomenologic Study About the Dietary Habits and Digestive Complications for People Living with Temporomandibular Joint Disorder. J Oral Facial Pain Headache. 2019 Jun 24;: Authors: Safour W, Hovey R Abstract AIMS: To better understand the experiences of individuals who must alter the types of food they eat because of having a chronic temporomandibular...
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Clinical Cases, Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart Transplantation...
Clinical Cases,Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart TransplantationPresentation of Case. Dr. Taylor A. Lebeis: A 52-year-old woman who had undergone orthotopic heart transplantation because of dilated cardiomyopathy was admitted to this hospital with painful red lesions on the left arm and leg. Eight years before this admission, the patient had ongoing episodes of…Clinical Cases5hCase 19-2019: A 38-Year-Old Woman with Abdominal Pain and FeverPresentation of Case. Dr....
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Osseous Sarcoidosis with a Solitary Lytic Skull Lesion: A Case Report5hby Thirunavukarasu, Vignaraja via Journal of Neurological Surgery ReportsJ Neurol Surg Rep 2019; 80: e27-e29DOI: 10.1055/s-0039-1687845Bone sarcoidosis is an uncommon manifestation of the multisystemic disease with skull involvement being rare. We present the case of a 32-year-old female who was referred by her General Practitioner with a left calvarial lesion on a background of previous unilateral 7th nerve palsy and diabetes...
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The New England Journal of Medicine: Images in Clinical Medicine,Thyroglossal Duct CystA 68-year-old woman presented to the otorhinolaryngology clinic with a 5-year history of swelling in the neck and the recent development of discomfort when she swallowed. On physical examination, she had a soft and nontender mass in the midline of the neck that moved with protrusion of the tongue…The New England Journal of Medicine: Search Results in Images in Clinical Medicine5hColovesical FistulaA 72-year-old...
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The New England Journal of Medicine: Hematology\Oncology, A CRISPR Way to Identify Cancer Targets...
The New England Journal of Medicine: Hematology\Oncology,A CRISPR Way to Identify Cancer TargetsThe premise of precision cancer medicine is elegantly simple. The basic concept involves the analysis — molecular and otherwise — of a tumor to identify key attributes that allow for the selection of therapeutic agents with a high likelihood of killing that particular tumor, while minimizing side…The New England Journal of Medicine: Search Results in Hematology\Oncology4hClinical and Genomic Risk to Guide...
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Sports Medicine,Do Self-Myofascial Release Devices Release Myofascia? Rolling Mechanisms: A Narrative ReviewAbstract The term "self-myofascial release" is ubiquitous in the rehabilitation and training literature and purports that the use of foam rollers and other similar devices release myofascial constrictions accumulated from scar tissue, ischaemia-induced muscle spasms and other pathologies. Myofascial tone can be modulated with rollers by changes in thixotropic properties, blood flow, and fascial...
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The New England Journal of Medicine: Allergy\Immunology,Five-Year Follow-up after Face TransplantationTo the Editor: Facial vascularized composite allograft transplantation holds the promise of restoring form and function to patients with severe facial disfigurement for whom other satisfactory treatment options are lacking. We previously reported the transplantation of full facial vascularized…The New England Journal of Medicine: Allergy\Immunology2hAn Anti-CD3 Antibody, Teplizumab, in Relatives...
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Translational gap in pediatric septic shock management: an ESPNIC perspective2hby Luc Morin, Martin Kneyber, Nicolaas J. G. Jansen, Mark J. Peters, Etienne Javouhey, Simon Nadel, Graeme Maclaren, Luregn Jan Schlapbach and Pierre Tissieres via Annals of Intensive Care - Latest ArticlesThe Surviving Sepsis Campaign and the American College of Critical Care Medicine guidelines have provided recommendations for the management of pediatric septic shock patients. We conducted a survey among the ...
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Journal of Cutaneous Medicine and Surgery: Hemoglobin Levels and Serum C-Reactive Protein in Patients With Moderate to Severe Hidradenitis SuppurativaJournal of Cutaneous Medicine and Surgery, Ahead of Print. Introduction:Anemia of chronic inflammation is associated with many inflammatory diseases. Little is known about anemia in hidradenitis suppurativa (HS). This study aimed to review the levels of hemoglobin (Hb) and investigate its relationship with serum C-reactive protein (CRP) and disease...
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Journal of Cutaneous Medicine and Surgery: Hemoglobin Levels and Serum C-Reactive Protein in Patients With Moderate to Severe Hidradenitis SuppurativaJournal of Cutaneous Medicine and Surgery, Ahead of Print. Introduction:Anemia of chronic inflammation is associated with many inflammatory diseases. Little is known about anemia in hidradenitis suppurativa (HS). This study aimed to review the levels of hemoglobin (Hb) and investigate its relationship with serum C-reactive protein (CRP) and disease...
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Lasers in Surgery and Medicine,A New Method for Percutaneous Drug Delivery by Thermo‐Mechanical Fractional InjuryBackground and Objectives Percutaneous drug delivery (PDD) is a means of increasing the uptake of topically applied agents into the skin. Successful delivery of a photosensitizer into the skin is an important factor for effective photodynamic therapy. To evaluate the efficacy of pretreatment by thermomechanical fractional injury (TMFI) (Tixel®, Novoxel®, Israel) at low‐energy settings...
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International Journal of Cancer,FRK plays an oncogenic role in nonsmall cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogrammingThe role of Fyn‐related kinase (FRK) in malignant tumors remains controversial. This study investigated the function of FRK in lung cancer. Immunohistochemistry staining and generating a knockout of FRK by CRISPR/Cas9 in H1299 (FRK‐KO‐H1299) cells were strategies used to explore the role of FRK. Immunohistochemistry staining indicated...
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Systematic Reviews - Educational outcomes of children in contact with social care in England: a systematic reviewIn England, the state intervenes in the lives of children through Children's Social Care (CSC) services with the aim of supporting and maintaining their welfare. It is known from government cross-sectional dat...Systematic Reviews - Latest Articles1hEffect of mobile text message reminders on routine childhood vaccination: a systematic review and meta-analysisThe World Health Organization...
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Diagnostic Cytopathology,Diagnosis of filariasis by cytology of unexplained ascitesDiagnostic Cytopathology1hMalignant risk of indeterminate pediatric thyroid nodules—An institutional experienceAbstract Background Few studies focus on pediatric thyroid nodules categorized under indeterminate diagnostic categories. The current study was conducted to assess the risk of malignancy of indeterminate pediatric thyroid nodules. Methods A search of the institutional electronic pathology database from 01/2011...
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Cancer,Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinomaBackground Checkpoint inhibitors have shown modest activity in patients with advanced hepatocellular carcinoma (HCC). Herein, the authors report a prospective single‐institution clinical/translational phase 2 study of pembrolizumab in patients with advanced HCC and circulating biomarkers closely related to response. Methods Pembrolizumab was administered...
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Cancers, Vol. 11, Pages 914: Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder CancerCancers, Vol. 11, Pages 914: Urinary Metabolic Signatures Detect Recurrences in Non-Muscle Invasive Bladder Cancer Cancers doi: 10.3390/cancers11070914 Authors: Alba Loras M. Carmen Martínez-Bisbal Guillermo Quintás Salvador Gil Ramón Martínez-Máñez José Luis Ruiz-Cerdá Patients with non-muscle invasive bladder cancer (NMIBC) undergo lifelong monitoring based on repeated cystoscopy and...
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Angewandte Chemie International Edition,Synthesis of Indoles through Domino Reactions of 2‐Fluorotoluenes and NitrilesIndoles galore: A remarkably easy synthesis of indoles is introduced. Simply combining 2‐fluorotoluenes, benzonitriles, base, and CsF followed by heating results in the formation of 2‐aryl indoles with diverse substitution patterns. Abstract Indoles are essential heterocycles in medicinal chemistry, and therefore, novel and efficient approaches to their synthesis are in high demand....
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Effects of transcutaneous electrical nerve stimulation (TENS) on the salivary flow of patients with hyposalivation induced by radiotherapy in the head and neck region – a randomized clinical trial1hby Émille Dalbem Paim, Monalise Costa Batista Berbert, Virgilio Gonzales Zanella, Vera Beatris Martins, Fabricio Edler Macagnanvia Journal of Oral RehabilitationAbstractIntroductionHyposalivation is a frequent complication after treatment with radiotherapy.ObjectiveEvaluate the efficacy of transcutaneous...
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Pest categorisation of non‐EU Cicadomorpha vectors of Xylella spp.55mby EFSA Panel on Plant Health (PLH), Claude Bragard, Katharina Dehnen‐Schmutz, Francesco Di Serio, Paolo Gonthier, Marie‐Agnès Jacques, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Christer Sven Magnusson, Panagiotis Milonas, Juan A Navas‐Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Hans‐Hermann Thulke, Wopke Van der Werf, Antonio Vicent Civera, Jonathan Yuen, Lucia Zappalà, Chris Malumphy, João Roberto...
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The New England Journal of Medicine: Cancer, Genetics,A CRISPR Way to Identify Cancer TargetsThe premise of precision cancer medicine is elegantly simple. The basic concept involves the analysis — molecular and otherwise — of a tumor to identify key attributes that allow for the selection of therapeutic agents with a high likelihood of killing that particular tumor, while minimizing side…The New England Journal of Medicine: Cancer, Genetics54mThe Precision of Evidence Needed to Practice "Precision...
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Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy54mby Peter Saliba‐Gustafsson, Matteo Pedrelli, Karl Gertow, Olivera Werngren, Vanessa Janas, Shirin Pourteymour, Damiano Baldassarre, Elena Tremoli, Fabrizio Veglia, Rainer Rauramaa, Andries J. Smit, Philippe Giral, Sudhir Kurl, Matteo Pirro, Ulf de Faire, Steve E Humphries, Anders Hamsten, on behalf of the IMPROVE study group, C.R. Sirtori, S. Castelnuovo, M. Amato, B. Frigerio,...
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The New England Journal of Medicine: Emergency Medicine,Nonbacterial Thrombotic EndocarditisFigure 1.The New England Journal of Medicine: Search Results in Emergency Medicine46mHeatstrokeHeatstroke is the most hazardous condition in a spectrum of illnesses progressing from heat exhaustion to heatstroke, in which a shared finding is hyperthermia (i.e. the rise in core body temperature when heat accumulation overrides heat dissipation during exercise or exposure to environmental heat…The New England...
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The New England Journal of Medicine: Otolaryngology,Five-Year Follow-up after Face TransplantationTo the Editor: Facial vascularized composite allograft transplantation holds the promise of restoring form and function to patients with severe facial disfigurement for whom other satisfactory treatment options are lacking. We previously reported the transplantation of full facial vascularized…The New England Journal of Medicine: Otolaryngology43mThyroglossal Duct CystFigure 1.The New England Journal...
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The Laryngoscope,Relationship of vocal fold atrophy to swallowing safety and cough function in Parkinson's diseaseObjectives When swallowing function is compromised in patients with Parkinson's disease (PD), cough plays a crucial role in clearing the airway and preventing pulmonary complications. The aim of this study was to determine the influence of vocal fold atrophy severity as measured by the bowing index (BI) on airway protection in PD. Methods Thirty participants with PD completed measures...
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A multicenter randomized open‐label comparative study of prabotulinumtoxinA with two different dosages and diverse proportional injection styles for the reduction of gastrocnemius muscle hypertrophy in Asian women40mby Youngchul Suh, Guk Jin Jeong, HyungJoo Noh, Sanghoon Sun, Chang Heon Hwang, Tae‐suk Oh, Beom Joon Kim via Wiley: Dermatologic Therapy: Table of ContentsABSTRACTA botulinum toxin (BTX) injection can be a simple and safe alternative to calf‐reduction surgery or liposuction without interrupting...
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International Forum of Allergy & Rhinology,Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferationBackground Damage to olfactory sensory neurons (OSNs), situated within the neuroepithelium of the olfactory cleft, may be associated with anosmia. Although their direct contact with the nasal airspace make OSNs vulnerable to injury and death, multiple mechanisms maintain epithelium integrity and olfactory function. We hypothesized that BMI1, a polycomb...
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The New England Journal of Medicine: Geriatrics\Aging,Serious-Illness Care 2.0 — Meeting the Needs of Patients with Heart FailureHeart failure is the most common cause of hospitalizations among elderly Americans, and despite much medical and scientific progress, it remains a source of substantial suffering, expense, and caregiver burden. Palliative care can improve quality of life, symptoms, and functioning for people with…The New England Journal of Medicine: Search Results in Geriatrics\Aging16mHeatstrokeHeatstroke...
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Current Neurology and Neuroscience Reports,Recent Advancement and Clinical Implications of 18FDG-PET in Parkinson's Disease, Atypical Parkinsonisms, and Other Movement DisordersAbstract Purpose of Review The molecular imaging field has been very instrumental in identifying the multiple network interactions that compose the human brain. The cerebral glucose metabolism is associated with neural function. 18F-fluoro-deoxyglucose-PET (FDG-PET) studies reflect brain metabolism in a pattern-specific manner....
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Oral Diseases,Information on oral cancer available on the internet: is it reliable?Abstract In 2018, the incidence of oral cancer was estimated to be 354,900 cases, resulting in 177,400 deaths worldwide (Ferlay et al., 2019). On diagnosis, most patients present the disease at an advanced clinical stage (Gigliotti, Madathil, & Makhoul, 2019). Delay in diagnosis is common and may be attributed to factors associated with the patient, health care provider, and treatment (Güneri, & Epstein, 2014)....
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Society for Linguistic Anthropology,Ask an Editor: Previously Published Articles as Book ChaptersIlana Gershon asked seven editors for their insights on questions that authors commonly ask. Five are press editors (Berghahn, Chicago, Indiana, Princeton, Stanford) and two are series editors. This month's column explores the following question: How many chapters of a book can be already in print as articles? Fred Appel: There is no hard and fast rule here. But if you plan a book that has six chapters...
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The New England Journal of Medicine: Neurology\Neurosurgery,Detection of Brain Activation in Unresponsive Patients with Acute Brain InjuryClinically unresponsive patients can have electroencephalographic (EEG) or magnetic resonance imaging (MRI) evidence of brain activation in response to spoken commands. A meta-analysis has reported that 14% of chronically unresponsive patients may have a dissociation between behavior and brain…The New England Journal of Medicine: Search Results in Neurology\Neurosurgery4mWhat...
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The New England Journal of Medicine: Allergy\Immunology,Five-Year Follow-up after Face TransplantationTo the Editor: Facial vascularized composite allograft transplantation holds the promise of restoring form and function to patients with severe facial disfigurement for whom other satisfactory treatment options are lacking. We previously reported the transplantation of full facial vascularized…The New England Journal of Medicine: Search Results in Allergy\Immunology4mAn Anti-CD3 Antibody, Teplizumab,...
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The Journal of Physiology,Spatial difference can occur between activated and damaged muscle areas following electrically‐induced isometric contractionsKey points T2 mapping combined to image registration and statistical parametric mapping analysis is a suitable methodology to accurately localize and compare the extent of both activated and damaged muscles areas. Activated muscle areas following electrically‐induced isometric contractions are superficial, but damaged regions are muscle‐specific and...
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Accuracy of Scanned Stock Abutments Using Different Intraoral Scanners: An In Vitro study 24mby Jong‐Eun Kim, Young‐Sun Hong, You‐Jung Kang, Jee‐Hwan Kim, June‐Sung Shim via Journal of ProsthodonticsAbstractPurposeTo determine the accuracy of a digital manufacturing method for dental implant restorations on stock abutments using intraoral scanners and prefabricated stock‐abutment libraries.Materials and MethodsTwo dental implants with internal hexagonal connections were placed in the mandibular second...
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Journal of Biophotonics,Quantitative assessment of microenvironment characteristics and metabolic activity in glioma via multiphoton microscopyAbstract Tumor microenvironment and metabolic activity in gliomas are the important biomarkers to evaluate the progression of gliomas. Many evidences have suggested that the targeting of metabolic activity and tumor microenvironment simultaneously can be more effective to take the tumor therapy. Therefore, the non‐invasive, accurate assessment of tumor microenvironment...
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The New England Journal of Medicine: Dermatolog,,Nintedanib for Systemic Sclerosis–Associated Interstitial Lung DiseaseSystemic sclerosis is a rare and heterogeneous autoimmune disease characterized by immune dysregulation, microvascular damage, and organ fibrosis. Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis that tends to occur early in the course of disease; the condition places…The New England Journal of Medicine: Search Results in Dermatology10mCase 20-2019:...
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Journal of Evolutionary Biology, Sexual selection and the evolution of sperm morphology in sharks...
Journal of Evolutionary Biology,Sexual selection and the evolution of sperm morphology in sharksAbstract Postcopulatory sexual selection, and sperm competition in particular, is a powerful selective force shaping the evolution of sperm morphology. While mounting evidence suggests that postcopulatory sexual selection influences the evolution of sperm morphology among species, recent evidence also suggests that sperm competition influences variation in sperm morphology at the intraspecific level. However,...
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Injury from E-Cigarette Explosion8mvia The New England Journal of Medicine: Search Results in SurgeryTranslate article
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The New England Journal of Medicine: Search Results in Surgery,Colovesical FistulaFigure 1.The New England Journal of Medicine: Search Results in Surgery8mFive-Year Follow-up after Face TransplantationTo the Editor: Facial vascularized composite allograft transplantation holds the promise of restoring form and function to patients with severe facial disfigurement for whom other satisfactory treatment options are lacking. We previously reported the transplantation of full facial vascularized…The...
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ournal of Medical Imaging and Radiation Oncology,After‐hours emergency radiology CT reporting by radiology registrars at an Australian level 1 trauma centre: A review of discrepancies between preliminary and final reportsAbstract Introduction There is reliance on radiology registrar reporting of after‐hours CT scans in many public hospitals across Australia and New Zealand. This study evaluates the extent and nature of CT reporting discrepancies after‐hours by comparing trainee preliminary reports...
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Cancer Science,Different sensitivities of senescent breast cancer cells to immune cell‐mediated cytotoxicityAbstract Senescence is a state of growth arrest induced in not only normal cells but also cancer cells by aging or stress, which triggers DNA damage. Despite growth suppression, senescent cancer cells promote tumor formation and recurrence by producing cytokines and growth factors; this state is designated as the senescence‐associated secretory phenotype (SASP). In this study, we examined the...
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Correction to: Real-World Data of Prasugrel vs. Ticagrelor in Acute Myocardial Infarction: Results from the RENAMI RegistryThe first author's name which previously read.Prasugrel and Ticagrelor: the Romulus and Remus of Antiplatelet Therapy?The Efficacy and Safety of Aerosolized Iloprost in Pulmonary Arterial Hypertension: A Systematic Review and Meta-AnalysisAbstractBackgroundThis systematic review and meta-analysis was conducted to investigate the efficacy and safety of the chronic administration...
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Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptomsAbstractBackgroundAversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms...
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Intradiaphragmatic Bronchogenic CystsThe Vein of Henle RevisitedEffective and Safe Living Donor Hepatectomy Under Intermittent Inflow Occlusion and Outflow Pressure ControlGastric Synovial SarcomaGiant Primary Retroperitoneal Dedifferentiated LiposarcomaPrimary Sarcomatoid Malignant Mesothelioma of the PancreasIleal Endometriosis: a Rare Cause of Enterocutaneous FistulaRobotic Single-Site Plus One Port: Pancreas EnucleationAbstractPurposeLaparoscopic approaches to enucleation of the pancreas have...
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select article The utility of narrow band imaging in endoscopic diagnosis of laryngopharyngeal refluxResearch articleAbstract onlyThe utility of narrow band imaging in endoscopic diagnosis of laryngopharyngeal refluxChangding He, Jinchao Yu, Fang Huang, Jun ShaoIn Press, Accepted Manuscript, Available online 28 June 2019Purchase PDFArticle previewAbstractAbstractObjectiveThis study assessed the utility of narrow band imaging (NBI) in patients with symptoms of laryngopharyngeal reflux (LPR) and tried...
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Vitamin D und Omega-3-Fettsäuren senken das Risiko für Krebs und kardiovaskuläre Ereignisse nichtDurvalumab nach einer Radiochemotherapie ist beim NSCLC im Stadium III derzeit die vielversprechendste TherapieRadiochirurgie und operative neurovaskuläre Dekompression annähernd gleichwertig bei der Behandlung von TrigeminusneuralgienTomotherapy in malignant mesothelioma: a planning study to establish dose constraintsAbstractPurposeA planning study was performed for helical tomotherapy treatment. We...
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Intellectual directions for History and Philosophy of the Life Sciences , 2019–2023From parts to mechanisms: research heuristics for addressing heterogeneity in cancer geneticsAbstractA major approach to cancer research in the late twentieth century was to search for genes that, when altered, initiated the development of a cell into a cancerous state (oncogenes) or failed to stop this development (tumor suppressor genes). But as researchers acquired the capacity to sequence tumors and incorporated...
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Arguing Against the Expressive Function of Punishment: Is the Standard Account that Insufficient?AbstractThis paper critically appraises the arguments that have been offered for what can be called 'the expressive function of punishment'. According to this view, what distinguishes punishment from other kinds of non-punitive hard treatment is that punishment conveys a censorial/reprobative message about what the punished has done, and that this expressive function should therefore be accepted as part...
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Correction to: Brentuximab vedotin use in a jaundiced case with resistant Hodgkin lymphomaThe original version of this article contained a mistake in one of the author names. Cem Irili should have been Cem Mirili.Isolated extramedullary leukemic involvement of the heart presenting as fulminant heart failureMultidimensional radar dot-plots, do we need it for the screening of acute promyelocytic leukemia?Geriatric nutritional risk index (GNRI) just before allogeneic hematopoietic stem cell transplantation...
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Impact of coccidiostat and phytase supplementation on gut microbiota composition and phytate degradation in broiler chickensAbstractBackgroundThere is good evidence for a substantial endogenous phytase activity originating from the epithelial tissue or the microbiota resident in the digestive tract of broiler chickens. However, ionophore coccidiostats, which are frequently used as feed additives in broiler diets to prevent coccidiosis, might affect the bacterial composition and the abundance of phytase...
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AI in Interventional Radiology: There is Momentum for High-Quality Data RegistriesIntraabdominal Hemorrhage from Ruptured Ectopic Varices Treated by Antegrade Embolization via a Recanalized Paraumbilical VeinAbstractA 49-year-old man with alcoholic liver cirrhosis was admitted to our hospital with abdominal pain. Contrast-enhanced CT demonstrated massive hemorrhagic ascites and ectopic varices fed by right colic and ileocolic veins. The varices were treated with selective embolization via a recanalized...
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Climatic variations within the dry valleys in southwestern China and the influences of artificial reservoirsAbstractClimatic variation within a typical dry-valley area located in the southern Hengduan Mountains of China is studied, and the potential regional climate influences of large reservoirs in the area are discussed. Six meteorological stations near a reservoir are identified and classified into two categories (dry and non-dry valleys) to compare their level of climate change. Temperatures...
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Ajay Kumar Mishra (Ed): Smart Ceramics: Preparation, Properties, and ApplicationsRaymond Hill, Terry Kenakin and Tom Blackburn (Eds): Pharmacology for Chemists—Drug Discovery in ContextCongress, Conferences, and WorkshopsIdentification and Quantification of Related Impurities of a Novel Ketolide Antibiotic NafithromycinAbstractNafithromycin (NFT, WCK 4873) is a novel antimicrobial drug being developed to treat infections caused by Gram-positive bacteria. It is a second-generation drug of the lactone...
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Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal PathwayAbstractObjective: To explore the specific molecular mechanisms of Danshensu (DSS) in the treatment of ischemia reperfusion injury (IRI). Methods: IRI model was established with isolated rat hearts by performing global ischaemia for 30 min, and then followed by 60 min reperfusion. Also, H9C2 cells were subjected to 4-h hypoxia followed by 3-h reoxygenation. Then 10 μmol/L DSS were added in...
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Prioritizing PlatonismAbstractSome see concrete foundationalism as providing the central task for sparse ontology, that of identifying which concreta ground other concreta but aren't themselves grounded by concreta. There is, however, potentially much more to sparse ontology. The thesis of abstract foundationalism, if true, provides an additional task: identifying which abstracta ground other abstracta but aren't themselves grounded by abstracta. We focus on two abstract foundationalist theses—abstract...
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Correction to: Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)The last author's first name was truncated in the initial online publication. The original article has been corrected.Nomograms for predicting the overall and cause-specific survival in patients with malignant peripheral nerve sheath tumor: a population-based studyAbstractBackgroundMalignant...
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Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal PathwayAbstractObjective: To explore the specific molecular mechanisms of Danshensu (DSS) in the treatment of ischemia reperfusion injury (IRI). Methods: IRI model was established with isolated rat hearts by performing global ischaemia for 30 min, and then followed by 60 min reperfusion. Also, H9C2 cells were subjected to 4-h hypoxia followed by 3-h reoxygenation. Then 10 μmol/L DSS were added in...
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Irma Elizabeth Gonzalez CurielLOS PÉPTIDOS ANTIMICROBIANOS Y SUS BENEFICIOS EN EL TRATAMIENTO DE LAS ÚLCERAS DE PIE DIÁBETICOEn la presente revisión se analiza, sobre la base de los estudios realizados tanto in vivocomo in vitro el posible uso de péptidos antimicrobianos y sus inductores en el tratamiento de úlceras de pie diabético.Seguir leyendoVivian MolinaTRATAMIENTO DE LA ISQUEMIA CEREBRAL GLOBAL EN JERBOS DE MONGOLIAEl tratamiento con dosis orales únicas de las combinaciones policosanol (100...
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¿Disminuyen las complicaciones cutáneas tras la cirugía de fracturas de tobillo con el uso de Aquacel Extra Ag®?Publication date: Available online 22 June 2019Source: Revista Española de Cirugía Ortopédica y TraumatologíaAuthor(s): M. Luque-Valenzuela, A.J. Sánchez-Aguilera, A. Martín-Vivaldi-Jiménez, R. Jódar-Graus, N. Prados-OlletaResumenIntroducciónLas fracturas de tobillo representan un 10% del total de fracturas. La mayor parte requieren tratamiento quirúrgico, que conlleva un importante riesgo...
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Effect of electroacupuncture on NF-κB and NLRP3 inflammasome in uterine tissues of rats with primary dysmenorrheaAbstractObjectiveTo observe the effect of electroacupuncture (EA) on nuclear factor kappa B (NF-κB) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in uterine tissues of rats with primary dysmenorrhea (PD), thus to explore the possible mechanism of EA for PD.MethodsFifty female Sprague-Dawley (SD) rats were randomly divided into a normal group,...
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Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular dockingAbstractA series of 2-chloro N-substituted amino quinolines (2a–2j) were prepared and characterized by analytical and spectroscopic methods. As quinoline is an important pharmacophoric moiety, the prepared compounds were screened against a non-small cell lung cancer cell line, A549. One of the compounds, 2-chloro-8-methyl-N-(quinolin-5-yl)quinolin-4-amine (2b) is found to be active with inhibition...
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A case of type A acute aortic dissection with a common carotid trunkAbstractWe present a rare case of common carotid artery with acute type A aortic dissection. A 72-year-old woman underwent emergent aortic arch repair using Antegrade selective cerebral protection. Bottom-tapped cannulae were inserted into three orifices of arch vessels, however, regional cerebral oxygen saturation decreased after rewarming. We found that arch branches were in order from front to back, right subclavian artery, common...
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The effect of exercise on memory and BDNF signaling is dependent on intensityAbstractThe aims of the present study were to investigate in brain of adult rats (1) whether exercise-induced activation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is dependent on exercise intensity modality and (2) whether exercise-induced improvement of memory is proportional to this pathway activation. Wistar rats were subjected to low (12 m/min) or high (18 m/min) exercise...
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Αλέξανδρος Γ. ΣφακιανάκηςPaediatric DermatologyChildhood psoriasis: Disease spectrum, comorbidities, and challengesSoumajyoti Sarkar, Sandipan Dhar, Siba P RaychaudhuriIndian Journal of Paediatric Dermatology 2019 20(3):191-198Psoriasis is a chronic, inflammatory, papulosquamous disorder with a variable clinical spectrum. Although it affects population of all age groups, the significance and negative impact of childhood psoriasis is often neglected worldwide. In nearly one-third of the psoriatic...
Fri Jun 28, 2019 16:45
Childhood psoriasis: Disease spectrum, comorbidities, and challengesSoumajyoti Sarkar, Sandipan Dhar, Siba P RaychaudhuriIndian Journal of Paediatric Dermatology 2019 20(3):191-198Psoriasis is a chronic, inflammatory, papulosquamous disorder with a variable clinical spectrum. Although it affects population of all age groups, the significance and negative impact of childhood psoriasis is often neglected worldwide. In nearly one-third of the psoriatic population, psoriasis appears during the childhood....
Fri Jun 28, 2019 16:41
Current market trends in anterior ocular inflammatory disease landscapePurpose of review In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. Recent findings In recent years, with improved understanding in pathophysiology of the AOID, providing novel targets for...
Fri Jun 28, 2019 16:40
The Correlation Analysis of Intralabyrinthine Hemorrhage Magnetic Resonance Imaging with Hearing Loss and Prognosis:A Retrospective Analysis of 207 casesClinical Otolaryngology, Volume 0, Issue ja, -Not available-. Evolving management strategies in head and neck paragangliomas: A single‐centre experience with 147 patients over a 60‐year periodClinical Otolaryngology, EarlyView. Functional relevance of Computational Fluid Dynamics in the field of nasal obstruction: a literature reviewClinical Otolaryngology,...
Fri Jun 28, 2019 15:12
Sialadenitis May Be Associated With an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort StudyPublication date: July 2019Source: Journal of Oral and Maxillofacial Surgery, Volume 77, Issue 7Author(s): Yi-Fang Huang, Shih-Ping Liu, Chih-Hsin Muo, Chung-Ta Chang, Chun-Hao Tsai, Donald E. MoriskyPurposeThe impact of sialadenitis on osteoradionecrosis (ORN) is controversial. The aim of this study was to determine the association between sialadenitis and ORN.Materials and MethodsParticipants...
Fri Jun 28, 2019 15:07
The Anesthetic Management of a Cardiac Transplant Patient Following Extensive Facial Trauma Caused by a Pit Bull AttackA 72-year-old male cardiac transplant patient presented after sustaining facial and extremity trauma caused by a pit bull dog attack. The case was further complicated by duration of the surgery, bleeding, infection risk, intraoperative hypothermia, immunosuppression, and the risk of sepsis. His anesthetic management required careful coordination with his transplant team. We also...
Fri Jun 28, 2019 15:06
Validation of targeted microsurgical spermatic cord denervation: comparison of outcomes to traditional complete microsurgical spermatic cord denervationParviz K KavoussiAsian Journal of Andrology 2019 21(4):319-323The aim of this study was to validate the effectiveness of targeted microsurgical spermatic cord denervation (MSCD) of the trifecta nerve complex in comparison to traditional full MSCD with complete skeletonization of the spermatic cord in men with chronic orchialgia. Retrospective chart...
Fri Jun 28, 2019 14:59
Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic EncephalopathyObjectives: Electroencephalogram features predict neurologic recovery following cardiac arrest. Recent work has shown that prognostic implications of some key electroencephalogram features change over time. We explore whether time dependence exists for an expanded selection of quantitative electroencephalogram features and whether accounting for this time dependence enables better prognostic predictions. Design:...
Fri Jun 28, 2019 14:58
It's a doc's life – Workplace violence against doctorsMrittika Sen, Santosh G HonavarIndian Journal of Ophthalmology 2019 67(7):981-984Machine learning in clinical care: Quo vadis?Vasant G HonavarIndian Journal of Ophthalmology 2019 67(7):985-986The second time aroundLi‐Anne L Lim, Md K Hasanuzzaman, Carol L ShieldsIndian Journal of Ophthalmology 2019 67(7):987-987Robotics and ophthalmology: Are we there yet?Suresh K Pandey, Vidushi SharmaIndian Journal of Ophthalmology 2019 67(7):988-994Ophthalmology...
Fri Jun 28, 2019 14:57
Association of serum Sestrin-2 level with insulin resistance, metabolic syndrome, and diabetic nephropathy in patients with type 2 diabetesHazem M EL-Ashmawy, Azza M AhmedThe Egyptian Journal of Internal Medicine 2019 31(2):107-114Background The aim of the study was to evaluate the relationship between serum Sestrin2, Insulin resistance (IR), metabolic syndrome (MetS), and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Patients and methods The study group consisted of...
Fri Jun 28, 2019 14:56
UntitledΑΛΕΞΑΝΔΡΟΣ Γ. ΣΦΑΚΙΑΝΑΚΗΣ at Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174 - 11 minutes agoPreclinical findings on the potential of intranasal neuropeptide Y for treating hyperarousal features of PTSD Thu Jun 27, 2019 21:13 by Chiso Nwokafor, Lidia I. Serova, Esther L. Sabban via Annals of the New York Academy of Sciences [image: Annals of the New York Academy of Sciences Preclinical findings on the potential of intranasal neuropeptide...
Fri Jun 28, 2019 13:10
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com
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