European Journal of Surgical Oncology (EJSO),Treatment of mid-bile duct carcinoma: Local resection or pancreatoduodenectomy?Publication date: Available online 29 June 2019Source: European Journal of Surgical OncologyAuthor(s): A. Marthe Schreuder, Anton F. Engelsman, Stijn van Roessel, Joanne Verheij, Marc G. Besselink, Thomas M. van Gulik, Olivier R. BuschAbstractIntroductionWhereas distal cholangiocarcinoma (DC) is treated by pancreatoduodenectomy (PD), consensus is lacking on treatment of mid-bile...
Psycho-Oncology,Barriers and Facilitators to Community‐Based Psycho‐oncology Services: A Qualitative Study of Health Professionals' Attitudes to the Feasibility and Acceptability of a Shared Care ModelAbstract Objective Psychological therapies combined with medication are effective treatments for depression and anxiety in patients with cancer. However, the psycho‐oncology workforce is insufficient to meet patient need and is hard to access outside of major cities. To bridge this gap, innovative...
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approachesPublication date: Available online 27 June 2019Source: Cancer Treatment ReviewsAuthor(s): Daniela Rodrigues, Terezinha Souza, Danyel G.J. Jennen, Lieve Lemmens, Jos C.S. Kleinjans, Theo M. de KokAbstractOne of the major complications that patients experience during pharmacological treatment is the occurrence of adverse drug reactions (ADRs). The most affected organs are the liver, kidney,...
Cancer Epidemiology,The burden of squamous cell carcinoma of the conjunctiva in AfricaPublication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Lucia Hämmerl, Jacques Ferlay, Margaret Borok, Carla Carrilho, Donald Maxwell ParkinAbstractSquamous cell carcinoma of the conjunctiva (SCCC) is a relatively common cancer in Africa, although its precise incidence and geographic distribution have not been previously systematically studied.MethodsUsing the methods employed to produce national...
Cancer Cell,RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy ResistancePublication date: Available online 27 June 2019Source: Cancer CellAuthor(s): Daniël A. Lionarons, David C. Hancock, Sareena Rana, Philip East, Christopher Moore, Miguel M. Murillo, Joana Carvalho, Bradley Spencer-Dene, Eleanor Herbert, Gordon Stamp, Djamil Damry, Dinis P. Calado, Ian Rosewell, Ralph Fritsch, Richard R. Neubig, Miriam Molina-Arcas,...
Cance...Interference with the Bromodomain Epigenome Readers Drives p21 Expression and Tumor SenescencePublication date: Available online 29 June 2019Source: Cancer LettersAuthor(s): Liana P. Webber, Veronica Q. Yujra, Pablo A. Vargas, Manoela D. Martins, Cristiane H. Squarize, Rogerio M. CastilhoAbstractHead and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the complications in managing and treating HNSCC...
Fibroblasts in cancer: Defining target structures for therapeutic interventionPublication date: Available online 29 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maximilian Boesch, Florent Baty, Holger Rumpold, Sieghart Sopper, Dominik Wolf, Martin H. BrutscheAbstractThe functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor...
Feasibility of proton FLASH effect tested by zebrafish embryo irradiation Sat Jun 29, 2019 03:00 ...
Feasibility of proton FLASH effect tested by zebrafish embryo irradiationSat Jun 29, 2019 03:00by Elke Beyreuther, Michael Brand, Stefan Hans, Katalin Hideghéty, Leonhard Karsch, Elisabeth Leßmann, Michael Schürer, Emília Rita Szabó, Jörg Pawelke via Radiotherapy and OncologyDuring the last decades, radiotherapy dose delivery techniques were notably improved with respect to tumor conformity, e.g., by sophisticated beam delivery techniques like intensity modulated radiation therapy. One disadvantage...
Radiation and Environmental Biophysics,Radiation interaction parameters for blood samples of breast cancer patients: an MCNP studyAbstract The main goal of this study was to determine radiation interaction parameters such as mass attenuation coefficients, effective atomic numbers, and effective electron densities depending on element concentrations (Na, K, Cu, Zn, Al, Ca, Mg Cr, Fe, Se) in blood samples of patients with breast cancer. Eighty blood samples were collected and analyzed in this study...
Practical Radiation Oncology,Thoracic radiotherapy in patients with entirely intracardiac leadless cardiovascular implantable electronic devices: two case reports and a review of the literaturePublication date: Available online 29 June 2019Source: Practical Radiation OncologyAuthor(s): Cory Pierson, Runyon Woods, Rajasekhar Nekkanti, Hyder Arastu, Robert Corns, Andrew W. JuPractical Radiation OncologySat Jun 29, 2019 13:51Quality of life and decision regret after postoperative radiation therapy...
WHAT IS COXSACKIE B VIRUS?The Coxsackie virus was first isolated in Coxsackie, New York in 1948. There are sixdifferent Coxsackie B viruses, each responsible for different symptoms and diseases.Coxsackie B viruses are responsible for numerous cases of central nervous systeminfections in infants and children, as well as heart muscle infections in both childrenand adults. These viruses are the most common agent for myocarditis (inflammationof the muscular walls of the heart) and dilated cardiomyopathy...
J. Hyg., Camb. (1983), 90, 327-332 327Printed in Great BritainEDITORIALTests for coxsackie B virus-specific 1gMDuring the last 10-15 years there has been a relative decline in virus isolationprocedures and an increasing emphasis on both direct antigen detection byimmunological methods and serological tests for the diagnosis of recent virusinfections. This relative decline has been due to a number of factors. There havebeen increasing difficulties in maintaining a suitably wide range of cell culturesystems...
Practical Radiation Oncology,Thoracic radiotherapy in patients with entirely intracardiac leadless cardiovascular implantable electronic devices: two case reports and a review of the literaturePublication date: Available online 29 June 2019Source: Practical Radiation OncologyAuthor(s): Cory Pierson, Runyon Woods, Rajasekhar Nekkanti, Hyder Arastu, Robert Corns, Andrew W. JuPractical Radiation OncologySat Jun 29, 2019 13:51Quality of life and decision regret after postoperative radiation therapy...
Pediatric Blood & Cancer,A newborn case of jejunal ALK‐negative inflammatory myofibroblastic tumor with ETV6‐NTRK3 fusionPediatric Blood & CancerFri Jun 28, 2019 22:00Sustained remission with azacitidine monotherapy and an aberrant precursor B‐lymphoblast population in juvenile myelomonocytic leukemiaAbstract Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. The hypomethylating...
Clinical Cancer Research current issue,Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration-resistant Prostate CancerPurpose:The bromodomain and extraterminal (BET)-containing proteins (BRD2/3/4) are essential epigenetic coregulators for prostate cancer growth. BRD inhibitors have shown promise for treatment of metastatic castration-resistant prostate cancer (mCRPC), and have been shown to function even in the context of resistance to next-generation...
Fibroblast growth factor receptor promotes progression of cutaneous squamous cell carcinomaSat Jun 29, 2019 15:28by Alok R. Khandelwal, Burton Kent, Savage Hillary, Md Maksudul Alam, Xiaohua Ma, Xin Gu, John DiGiovanni, Cherie‐Ann O. Nathanvia Molecular CarcinogenesisAbstractCutaneous squamous cell carcinoma (cSCC) is a keratinocyte‐derived invasive and metastatic tumor of the skin. It is the second‐most commonly diagnosed form of skin cancer striking 200 000 Americans annually. Further, in organ...
Molecular Cancer Therapeutics Online First Articles,Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximabEpidermal growth factor receptor (EGFR)-mutated lung cancer is a significant subgroup of non-small cell lung cancer. To inhibit EGFR-mediated signals, multiple EGFR tyrosine kinase inhibitors (EGFR-TKIs) have been developed; however, approximately one-third of patients with EGFR-mutated lung cancer do not respond to EGFR-TKIs....
Molecular Cancer Therapeutics current issue,Highlights of This IssueMolecular Cancer Therapeutics current issue10:05A Novel Fully Human Antibody targeting Extracellular Domain of PSMA Inhibits Tumor Growth in Prostate CancerProstate cancer is the most commonly diagnosed malignancy in men and the second leading cause of cancer-related death. It is of vital importance to develop new strategies for prostate cancer therapy. PSMA (prostate-specific membrane antigen) is specifically expressed in prostate...
Latest Results for Genes, Analysis of longissimus muscle quality characteristics and associations...
Latest Results for Genes,Analysis of longissimus muscle quality characteristics and associations with DNA methylation status in cattleAbstract Background As cattle represent one of the most important livestock species for meat production, control of muscle development in regards to quality is an important research focus. Objectives In this study, the phenotypic quality traits and its associations with DNA methylation levels of the longissimus muscle in two cattle breeds were studied. ...Latest Results...
Reduced CTL motility and activity in avascular tumor areasFri Jun 28, 2019 03:00via Latest Results for Cancer Immunology, ImmunotherapyAbstractPatchy infiltration of tumors by cytotoxic T cells (CTLs) predicts poorer prognosis for cancer patients. The factors limiting intratumoral CTL dissemination, though, are poorly understood. To study CTL dissemination in tumors, we histologically examined human melanoma samples and used mice to image B16-OVA tumors infiltrated by OT-I CTLs using intravital two-photon...
Molecular analysis of virulence factors of hypermucoviscous <em>Klebsiella pneumoniae</em> in a diabetes patient with multifocal intramuscular and musculoskeletal abscessesSun Jun 30, 2019 17:24via Journal of Infection and ChemotherapyPublication date: Available online 29 June 2019Source: Journal of Infection and ChemotherapyAuthor(s): Masataka Kudo, Takashi Matono, Masatomo Morita, Hidemasa Izumiya, Makoto Ohnishi, Junichi Hasegawa, Migiwa Izumi, Mai Yoshino, Ken Arai, Hiroshi ImuraAbstractUnusual...
HNL (Human Neutrophil Lipocalin) and a multimarker approach to the distinction between bacterial and viral infections.Sun Jun 23, 2019 00:00by Journal of Immunological Methods via Journal of Immunological MethodsCONCLUSION: The diagnostic performance of whole blood activated HNL was superior in the distinction between bacterial or viral infections. The addition of IP-10 and/or TRAIL to the diagnostic algorithm increased the performance of B-HNL further. The rapid analysis of HNL, reflecting bacterial...
International Journal of Cancer,Cancer in Africa 2018: the role of infectionsWe estimate the fractions of cancer attributed to infections in Africa in 2018. The number of new cancer cases occurring were taken from Globocan2018 with some additional estimations based on data from African population‐based registries. Population attributable fractions were calculated using prevalence of infection and relative risk in exposed versus non‐exposed. The greatest share of infection‐associated cancers is due...
The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervixBohan Li, Ling Zhang, Jianguo Zhao, Guichun Tan, Wenwen Zhang, Na Zhang, Jing Tian and Pengpeng QuEmail authorView ORCID ID profileInfectious Agents and Cancer201914:16https://doi.org/10.1186/s13027-019-0231-z© The Author(s). 2019Received: 1 March 2019Accepted: 7 June 2019Published: 28 June 2019AbstractBackgroundCervical cancer is a common cancer among women...
Current Treatment Options in Oncology,Emerging Role of Genomics and Cell-Free DNA in Breast CancerOpinion statement Precision Medicine is gaining momentum as the future gold standard healthcare strategy as it enables treatment optimization and consequently a potential improvement for quality of life and survival. This paradigm shift was possible thanks to new high-throughput genomics technologies, which provide prognostic and predictive information on tumor biology and potential treatment options,...
Critical Reviews in Oncology/Hematology (open access),Clinical Considerations for the Use of FLT3 Inhibitors in Acute Myeloid LeukemiaPublication date: Available online 28 June 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Taylor M. Weis, Bernard L. Marini, Dale L. Bixby, Anthony J. PerissinottiAbstractInternal tandem duplications and tyrosine kinase mutations in the fms-like tyrosine kinase 3 (FLT3) receptor can occur in acute myeloid leukemia (AML) and portend a poor prognosis....
Comparative and Functional Genomics — Overexpression of SlGRAS7 Affects Multiple Behaviors Leading to Confer Abiotic Stresses Tolerance and Impacts Gibberellin and Auxin Signaling in TomatoAbiotic stresses remain the key environmental issues that reduce plant development and therefore affect crop production. Transcription factors, such as the GRAS family, are involved in various functions of abiotic stresses and plant growth. The GRAS family of tomato (Solanum lycopersicum), SlGRAS7, is described...
Clinical Cancer Research Online First Articles,Prognostic score and cytogenetic risk classification for chronic lymphocytic leukemia patients: Center for International Blood and Marrow Transplant Research reportPurpose: To develop a prognostic model and cytogenetic risk classification for previously treated patients with chronic lymphocytic leukemia (CLL) undergoing reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT). Experimental Design: We performed a retrospective...
Clinical and Translational Science,Dose Finding in the Clinical Development of 60 US Food and Drug Administration–Approved Drugs Compared With Learning vs. Confirming RecommendationsThis review characterizes clinical development that supported the label dose in 60 drug indications recently approved by the US Food and Drug Administration. With Lewis B. Sheiner's Learning vs. Confirming clinical drug development paradigm as a reference point, the clinical development paths, the design of dose‐ranging...
Cancer Research current issue,APC/C-CDH1-Regulated IDH3{beta} Coordinates with the Cell Cycle to Promote Cell ProliferationMetabolic activities are often accompanied by cell-cycle progression, yet known connections between these two processes remain limited. Here, we identified the isocitrate dehydrogenase 3β (IDH3β) as a novel substrate of anaphase-promoting complex/cyclosome (APC/C)-CDH1 and an important regulator of the cell cycle. In esophageal squamous cell carcinoma (ESCC), IDH3β was posttranslationally...
Cancer Discovery current issue,Anti-BCMA CAR T-cell Therapy Reins in Myeloma [News in Brief]Autologous immune cells genetically engineered to target B-cell maturation antigen can help patients with relapsed or refractory multiple myeloma achieve deep molecular remissions with minimal neurotoxicity, according to initial data from a phase I trial.Cancer Discovery current issue10:05Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow [In the Spotlight]Summary:Macrophages modulate tumor response...
Cancer,Patient‐reported sexual quality of life after different types of radical prostatectomy and radiotherapy: Analysis of a population‐based prospective cohortBackground Although patients with prostate cancer face many treatment options, to the authors' knowledge the comparative effects of different surgical and radiotherapy (RT) options on sexual function are unclear. Methods In the current study, a population‐based cohort of 835 men with newly diagnosed prostate cancer from 2011 through 2013...
The Correlation Analysis of Intralabyrinthine Hemorrhage Magnetic Resonance Imaging with Hearing Loss and Prognosis:A Retrospective Analysis of 207 casesJinye Li Mingming Wang Lixin Sun Hui Zhao Gesheng Song Jing Tian Na Hu Min Li Weiqiang Dou Jianxun Qu Haibo Wang Ruozhen GongFirst published: 26 June 2019 https://doi.org/10.1111/coa.13397This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading...
Functional relevance of Computational Fluid Dynamics in the field of nasal obstruction: a literature reviewThomas Radulesco Lionel Meister Gilles Bouchet Jérôme Giordano Patrick Dessi Pierre Perrier Justin MichelFirst published: 24 June 2019 https://doi.org/10.1111/coa.13396This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version...
The Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary ReviewJérôme R. Lechien Vinciane Muls Giovanni Dapri François Mouawad Pierre Eisendrath Antonio Schindler Andrea Nacci Maria Rosaria Barillari Camille Finck Sven Saussez … See all authorsFirst published: 23 June 2019 https://doi.org/10.1111/coa.13395This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting,...
Evolving management strategies in head and neck paragangliomas: A single‐centre experience with 147 patients over a 60‐year periodJ.A. Rijken B. de Vos L.P. van Hest K.M.A. Dreijerink M. den Heijer W. Wisselink G.J. Blom E.F. Hensen C.R. LeemansFirst published: 24 May 2019 https://doi.org/10.1111/coa.13380The material in this manuscript is original research, has not been previously published and has not been submitted for publication elsewhere.The copyright line for this article was changed...
Low-risk gestational trophoblastic neoplasia: A single-center experience from Saudi ArabiaAbdulaziz Alobaid, Samer Ahmeed, Mohammed Abuzaid, Latifa Aldakhil, Ahmed Abu-ZaidAvicenna Journal of Medicine 2019 9(3):89-93Objective: To report our single-center experience in terms of patient clinical characteristics, treatment outcomes, and chemotherapy-related toxicities in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials and Methods: A retrospective cross-sectional study (2008–2013)...
Improving validity and reliability of homoeopathyRaj Kumar ManchandaIndian Journal of Research in Homoeopathy 2019 13(2):69-71Retrospective estimation of prevalence and likelihood ratio of general symptoms of 29 less frequently prescribed homoeopathic medicines by clinical verificationRaj K Manchanda, Parthasarathi Chakraborty, Munmun Koley, Dinesh Singh, Pramodji Singh, Ojit Singh, Varanasi Gayatri Prasad, Jai Prakash Singh, Surinder Singh Nain, Prasant Kumar Pradhan, Sunil S Ramteke, Ramesh Bawaskar,...
Periodontal health: A welcome additionAshish KumarJournal of Indian Society of Periodontology 2019 23(4):297-298Indian Society of Periodontology: The pillar of periodonticsAnil MelathJournal of Indian Society of Periodontology 2019 23(4):299-300Are we addressing the core issues through bridge course?Abhay KolteJournal of Indian Society of Periodontology 2019 23(4):301-302Effect of scaling and root planing as monotherapy on glycemic control in patients of Type 2 diabetes with chronic periodontitis:...
