[ASAP] A Self-Healing, All-Organic, Conducting, Composite Peptide Hydrogel as Pressure Sensor and Electrogenic Cell Soft Substrate

ACS Nano

DOI: 10.1021/acsnano.8b05067

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2Ar8r0l

[ASAP] Fully Packaged Portable Thin Film Biosensor for the Direct Detection of Highly Pathogenic Viruses from On-Site Samples

ACS Nano

DOI: 10.1021/acsnano.8b08298

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SziZ4M

[ASAP] Metal-Assisted Transfer Strategy for Construction of 2D and 3D Nanostructures on an Elastic Substrate

ACS Nano

DOI: 10.1021/acsnano.8b06623

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2AkWYPJ

[ASAP] Nanostructural and Electrochemical Evolution of the Solid-Electrolyte Interphase on CuO Nanowires Revealed by Cryogenic-Electron Microscopy and Impedance Spectroscopy

ACS Nano

DOI: 10.1021/acsnano.8b08012

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SuYENQ

[ASAP] DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single-Molecule Control

ACS Nano

DOI: 10.1021/acsnano.8b08010

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2Ailz83

[ASAP] Correction to Conversion Reaction of Nanoporous ZnO for Stable Electrochemical Cycling of Binderless Si Microparticle Composite Anode

ACS Nano

DOI: 10.1021/acsnano.8b08958

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SuYyWu

Association of autonomic symptoms with disease progression and survival in progressive supranuclear palsy

Background

Development of autonomic failure is associated with more rapid disease course and shorter survival in patients with Parkinson's disease and multiple system atrophy. However, autonomic symptoms have not been specifically assessed as a prognostic factor in progressive supranuclear palsy (PSP). We evaluated whether development of autonomic symptoms is associated with disease progression and survival in PSP.

Methods

A retrospective review of clinical data from consecutive patients with autopsy-confirmed PSP from the Queen Square Brain Bank between January 2012 and November 2016 was performed. Time from disease onset to four autonomic symptoms (constipation, urinary symptoms, erectile dysfunction and orthostatic hypotension) were noted. Time from diagnosis to five disease milestones and survival were calculated to assess disease progression, and their risk was estimated through a Cox proportional hazards model.

Results

A total of 103 PSP patients were included. Urinary symptoms and constipation were present in 81% and 71% of cases, respectively. Early development of constipation and urinary symptoms were associated with higher risk of reaching the first disease milestone (respectively, HR: 0.88; 95% CI 0.83 to 0.92; p<0.001; and HR: 0.80; 95% CI 0.75 to 0.86; p<0.001) and with a shorter survival in these patients (respectively, HR: 0.73; 95% CI 0.64 to 0.84; p<0.001; and HR: 0.88; 95% CI 0.80 to 0.96; p=0.004). On multivariate analysis, Richardson syndrome phenotype was the other variable independently associated with shorter survival.

Conclusions

Earlier urinary symptoms and constipation are associated with a more rapid disease progression and reduced survival in patients with PSP.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2LGFVMH