Akute Bronchitis

Dtsch med Wochenschr 2019; 144: 185-188
DOI: 10.1055/a-0655-8058

Stand der Dinge Die akute Bronchitis ist eine selbstlimitierende, akute Entzündung der Atemwege und tritt meistens im Rahmen einer viral bedingten Erkältung in Erscheinung. Obwohl sie in der Regel nach zwei bis drei Wochen selbstlimitierend abklingt, sind viele Patienten ungeduldig und fordern mitunter eine Antibiotikabehandlung. Diagnostik Anamnese und körperliche Untersuchung sind bei unkomplizierter akuter Bronchitis ausreichend. Bei älteren, multimorbiden oder immunsupprimierten Patienten oder Auffälligkeiten bei Vitalparametern ist eine weitergehende Differenzialdiagnostik notwendig. Die Bestimmung des Procalcitonins konnte in prospektiven Studien bisher keinen sicheren Nutzen zeigen. Therapie Bei der unkomplizierten akuten Bronchitis erfolgt eine symptomatische Therapie. Um Fehlverschreibungen zu verhindern, sind die Edukation von Arzt und Patient sowie eine Verschreibung erst bei Zweitkontakt erfolgreich. Die antibiotische Therapie bleibt einem Risikokollektiv vorbehalten. Es bleibt abzuwarten, ob mittels Procalcitonin in Zukunft Patienten bestimmt werden können, bei denen auf eine antibiotische Therapie verzichtet werden kann.
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© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2MH45ac

Aus den Gremien

Dtsch med Wochenschr 2019; 144: 218-219
DOI: 10.1055/a-0818-7202

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2sWTTRY

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells

Planta Med
DOI: 10.1055/a-0837-0975

Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the Epimedium plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. In this study, we investigated the potential protective effect of icariin on high glucose-induced detrimental effects on vascular endothelial cells. Human umbilical venous endothelial cells were incubated in media containing 5.5 mM glucose (normal glucose) or 25 mM glucose (high glucose) in the presence or absence of 50 µM icariin for 72 h. We found that high glucose markedly induced cell apoptosis, enhanced reactive oxygen species generation, and elevated expression levels of inflammatory factors and cell adhesion molecules, which were greatly subdued by icariin supplementation. In conclusion, icariin exerted a beneficial effect on high glucose-induced endothelial dysfunction. This new finding provides a promising strategy for future treatment of diabetic vascular complications.
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Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2Gd67h7

[Editorial] Adding insult to injury—redefining domestic abuse

It is often the most sensational and horrific stories of abuse and violence that make headlines. Claire Throssell endured years of physical and emotional abuse by her ex-husband and was forced to be cross-examined by him during hearings for visitation with their sons. Fearing losing access to them, he later purposefully started a house fire in South Yorkshire, UK, that killed both children. Yet beyond visibly shocking events lie the stealthier forms of non-physical abuse such as verbal or economic ill treatment.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SokYvW

[Comment] Never too old for statin treatment?

In 2005, in a participant-level meta-analysis of large randomised controlled trials, the Cholesterol Treatment Trialists' (CTT) Collaboration conclusively showed that for most patients HMG-CoA reductase inhibitors (statins) reduced major adverse cardiovascular events.1 Since then, generic versions of commonly used statins have become available. An evidence-based life-saving class of drugs with minimal known side-effects is therefore available, and are largely affordable even in lower income countries and for national health services.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SbsIRR

[Perspectives] A tense moment in the emergency room

The young man stormed into the doctors' station in a far corner of the emergency room, and held up his toddler. "My baby's choking and you guys aren't doing anything", he yelled, the ends of his cornrows slashing against his sweatshirt. This work station was set behind a staff meeting room, so it was clear that the father had entered spaces that were typically off-limits to patients. As soon as he shouted his opening statement, every person on the medical team froze.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2SbsB8T

[Correspondence] Global burden of postoperative death

The Lancet Commission on Global Surgery1 identified that 313 million surgical procedures are performed worldwide each year. Little is known about the quality of surgery globally because robust reports of postoperative death rates are available for only 29 countries.2 The rate of postoperative deaths is a measure of the success of surgical care systems, and improving this metric is a global priority.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2Sbsz0L