IJMS, Vol. 20, Pages 634: The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases

IJMS, Vol. 20, Pages 634: The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases

International Journal of Molecular Sciences doi: 10.3390/ijms20030634

Authors: Rosaria Di Mauro Giuseppina Cantarella Renato Bernardini Michelino Di Rosa Ignazio Barbagallo Alfio Distefano Lucia Longhitano Nunzio Vicario Daniela Nicolosi Giacomo Lazzarino Daniele Tibullo Maria Eugenia Gulino Mariarita Spampinato Roberto Avola Giovanni Li Volti

Ozone therapy has been widely used in everyday clinical practice over the last few years, leading to significant clinical results in the treatment of herniated discs and pain management. Nevertheless, further studies have demonstrated its potential efficacy and safety under other clinical and experimental conditions. However, some of these studies showed controversial results regarding the safety and efficacy of ozone therapy, thus mining its potential use in an everyday clinical practice. To this regard, it should be considered that extensive literature review reported the use of ozone in a significant different dose range and with different delivery systems. The aim of the present review is to describe the various pharmacological effects of ozone in different organs and clinical conditions and to provide possible biochemical and molecular insights for ozone biological properties, thus providing a possible explanation for various controversial clinical outcomes described in the scientific literature.

from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2TuoulK