Publication date: Available online 31 December 2018
Source: Biochimie
Author(s): Suveena Ranzil, David W. Walker, Anthony J. Borg, Euan M. Wallace, Peter R. Ebeling, Padma Murthi
Abstract
Fetal growth restriction (FGR) is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT) is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.
from ! Human Diseases via Alexandros G.Sfakianakis on Inoreader http://bit.ly/2s5b6bi
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