Abstract
Purpose
Although particulate matter (PM) is reported to affect the rate of emergency admissions for schizophrenia, no study has examined the relationship between particulate matter less than 2.5 μm in diameter (PM2.5) and the severity of schizophrenia.
Methods
We obtained data on patients with schizophrenia at a psychiatric hospital, and on air pollution in Sakai, Japan between Feb 1, 2013 and April 30, 2016. Multivariate logistic regression analyses were used to estimate the relationship between PM2.5 concentrations and scores on the Brief Psychiatric Rating Scale (BPRS) of schizophrenia patients at admission, with a lag of up to 7 days.
Results
During the study period, there were 1193 schizophrenia cases. The odds ratio (OR) for a BPRS score ≥ 50 at admission was 1.05 [95% confidence interval 1.00–1.10] and the effect of PM2.5 concentration was significant for lag period of 2 days. The ORs associated with PM2.5 concentration increased substantially for patients over 65 years of age.
Conclusions
Ambient PM2.5 concentration was associated with exacerbation of schizophrenia. Our results suggest that protection for several days should be considered for controlling PM2.5-related schizophrenia, especially among elderly patients.
from Enviromental via alkiviadis.1961 on Inoreader https://ift.tt/2qO2mXa
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου